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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1980 1
1982 3
1984 1
1985 1
1986 1
1987 3
1988 12
1989 191
1990 519
1991 633
1992 734
1993 832
1994 938
1995 1185
1996 1448
1997 1437
1998 1529
1999 1776
2000 1855
2001 1975
2002 2220
2003 3045
2004 3321
2005 3958
2006 4580
2007 5144
2008 5507
2009 5618
2010 6229
2011 7002
2012 8163
2013 9676
2014 10675
2015 12256
2016 11983
2017 11932
2018 12075
2019 6244
2020 98
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129,629 results
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Page 1
Nutrigenomics in cancer: Revisiting the effects of natural compounds
Braicu C, et al. Semin Cancer Biol 2017 - Review. PMID 28676460
The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting with bioactive compounds and nutrients, based on new 'omics' technologies. ...By deciphering the network of nutrient-gene connections associated with cancer, relevant data will be transposed as therapeutic interventions for this devastating pathology and for fulfilling the concept of personalized nutrition. ...
The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression
MicroRNA-Dependent Regulation of IGF1R Gene Expression in Hormone-Sensitive and Hormone-Resistant Prostate Cancer Cells.
Tarasov VA, et al. Dokl Biochem Biophys 2018. PMID 29779108
Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA expression in the normal prostate tissue cells. We found that the insulin-like growth factor 1 receptor (IGF1R) gene is a target of five microRNAs whose expression is increased in LNCaP cells and reduced in DU-145 cells....
Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene
Cancer-associated fibroblasts affect breast cancer cell gene expression, invasion and angiogenesis.
Eiro N, et al. Cell Oncol (Dordr) 2018. PMID 29497991
Here, we aimed to explore the influence of CAFs on breast cancer gene expression, as well as on invasion and angiogenesis. METHODS: qRT-PCR was used to evaluate the expression of several cancer progression related genes (S100A4, TGFβ, FGF2, FGF7, PDGFA, PDGFB, VEGFA, IL-6, IL-8, uPA, MMP2, MMP9, MMP11 and TIMP1) in the human breast cancer-derived cell lines MCF-7 and MDA-MB-231, before and after co-culture with CAFs. ...CONCLUSIONS: Our data indicate that tumor-derived CAFs can induce up-regulation of genes involved in breast cancer progression. ...
Here, we aimed to explore the influence of CAFs on breast cancer gene expression, as well as on invasion and angiogenesis. MET …
Emerging Contributions of Cancer/Testis Antigens to Neoplastic Behaviors.
Gibbs ZA and Whitehurst AW. Trends Cancer 2018 - Review. PMID 30292353 Free PMC article.
Tumors of nearly every origin activate the expression of genes normally restricted to gametogenic cells. These genes encode proteins termed cancer/testis (CT) antigens, since expression outside of their naturally immune-privileged site can evoke an immune response. ...These advances indicate the inherent flexibility of tumor cell regulatory networks to engage aberrantly expressed proteins to promote neoplastic behaviors, which could ultimately present novel therapeutic entry points....
Tumors of nearly every origin activate the expression of genes normally restricted to gametogenic cells. These genes encode proteins …
Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics
Urbanski LM, et al. Wiley Interdiscip Rev RNA 2018 - Review. PMID 29693319 Free PMC article.
Differential transcriptional and posttranscriptional regulation of splicing factors modulates their levels and activities in tumor cells. ...This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Processing > Splicing Regulation/Alternative Splicing....
Differential transcriptional and posttranscriptional regulation of splicing factors modulates their levels and activities in tumor ce …
Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome
Mahmoud AM and Ali MM. Nutrients 2019 - Review. PMID 30871166 Free PMC article.
DNA methylation is an epigenetic mechanism that is essential for regulating gene transcription. However, aberrant DNA methylation, which is a nearly universal finding in cancer, can result in disturbed gene expression. ...
DNA methylation is an epigenetic mechanism that is essential for regulating gene transcription. However, aberrant DNA methylation, wh …
Vimentin in cancer and its potential as a molecular target for cancer therapy
Satelli A and Li S. Cell Mol Life Sci 2011 - Review. PMID 21637948 Free PMC article.
This review summarizes the expression and functions of vimentin in various types of cancer and suggests some directions toward future cancer therapy utilizing vimentin as a potential molecular target....
This review summarizes the expression and functions of vimentin in various types of cancer and suggests some directions toward future …
SpatialDE: identification of spatially variable genes
Svensson V, et al. Nat Methods 2018. PMID 29553579 Free PMC article.
Technological advances have made it possible to measure spatially resolved gene expression at high throughput. However, methods to analyze these data are not established. ...SpatialDE also implements 'automatic expression histology', a spatial gene-clustering approach that enables expression-based tissue histology....
Technological advances have made it possible to measure spatially resolved gene expression at high throughput. However, method …
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