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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1983 1
1984 1
1985 5
1986 1
1987 10
1988 5
1989 70
1990 289
1991 485
1992 754
1993 492
1994 706
1995 789
1996 945
1997 1133
1998 1680
1999 1199
2000 1205
2001 1306
2002 1734
2003 2713
2004 3484
2005 3191
2006 3486
2007 3353
2008 3409
2009 3718
2010 4465
2011 4913
2012 5173
2013 5113
2014 5205
2015 5164
2016 5722
2017 6264
2018 7197
2019 3717
2020 71
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80,509 results
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Page 1
Post-transcriptional regulation of gene expression and human disease.
Corbett AH. Curr Opin Cell Biol 2018 - Review. PMID 29518673 Free PMC article.
Many of these RNA binding proteins mediate key steps in post-transcriptional regulation of gene expression from mRNA processing to eventual decay in the cytoplasm. ...This review summarizes steps in post-transcriptional regulation of gene expression that have been linked to disease providing specific examples of some of the many genes affected. ...
Many of these RNA binding proteins mediate key steps in post-transcriptional regulation of gene expression from mRNA pr …
Non-coding RNAs as regulators in epigenetics (Review)
Wei JW, et al. Oncol Rep 2017 - Review. PMID 27841002
Epigenetics is a discipline that studies heritable changes in gene expression that do not involve altering the DNA sequence. ...Non-coding RNAs are a cluster of RNAs that do not encode functional proteins and were originally considered to merely regulate gene expression at the post-transcriptional level. ...
Epigenetics is a discipline that studies heritable changes in gene expression that do not involve altering the DNA sequence. . …
Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression.
Pu M, et al. Cell Mol Life Sci 2019 - Review. PMID 30374521
MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a majority of biological processes via regulating target gene expression. ...With these discussions, we aim to emphasize the importance of miRNA regulatory network on target gene regulation and further highlight the potential application of the network mode in the achievement of a more effective and stable modulation of the target gene expression....
MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a majority of biological processes via regulating targ …
The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System.
Cholewa-Waclaw J, et al. J Neurosci 2016 - Review. PMID 27911745 Free PMC article.
Neuroepigenetics is a newly emerging field in neurobiology that addresses the epigenetic mechanism of gene expression regulation in various postmitotic neurons, both over time and in response to environmental stimuli. ...This article provides a selective review of the role of DNA and histone modifications in neuronal signal-induced gene expression regulation, plasticity, and survival and how targeting these mechanisms could advance the development of future therapies. ...
Neuroepigenetics is a newly emerging field in neurobiology that addresses the epigenetic mechanism of gene expression regul
Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation.
Dominguez AA, et al. Nat Rev Mol Cell Biol 2016 - Review. PMID 26670017 Free PMC article.
The bacterial CRISPR-Cas9 system has emerged as a multifunctional platform for sequence-specific regulation of gene expression. ...We highlight different uses in diverse organisms, including bacterial and eukaryotic cells, and summarize current applications of harnessing CRISPR-dCas9 for multiplexed, inducible gene regulation, genome-wide screens and cell fate engineering. ...
The bacterial CRISPR-Cas9 system has emerged as a multifunctional platform for sequence-specific regulation of gene express
miRNA Biogenesis: A Dynamic Pathway
Achkar NP, et al. Trends Plant Sci 2016 - Review. PMID 27793495
In this review we discuss our growing understanding of the dynamic regulation of miRNA biogenesis. We put special emphasis on crosstalk between miRNA biogenesis and other cellular processes such as transcription and splicing. We also discuss how the pathway is regulated in specific tissues to achieve harmonious plant development through a subtle balance between gene expression and silencing....
In this review we discuss our growing understanding of the dynamic regulation of miRNA biogenesis. We put special emphasis on crossta …
[Epigenetics of polycystic ovary syndrome]
Concha C F, et al. Rev Med Chil 2017 - Review. PMID 29182200 Spanish. Free article.
This evidence indicates that women with PCOS have a different epigenetic regulation, which might be triggered by an adverse intrauterine environment or by postnatal environmental elements such as diet and or obesity....
This evidence indicates that women with PCOS have a different epigenetic regulation, which might be triggered by an adverse intrauter …
Long non-coding RNAs: new players in cell differentiation and development
Fatica A and Bozzoni I. Nat Rev Genet 2014 - Review. PMID 24296535
Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. ...
Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long …
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