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Year Number of Results
1995 2
1996 1
1997 11
1998 39
1999 44
2000 47
2001 45
2020 0
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189 results
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Page 1
Melanoma genetics: an update with focus on the CDKN2A(p16)/ARF tumor suppressors.
Piepkorn M. J Am Acad Dermatol 2000 - Review. PMID 10775844
Molecular defects in both tumor suppressor genes and oncogenes have been pathogenically linked to melanoma in recent studies. ...LEARNING OBJECTIVE: At the conclusion of this learning activity, participants should be familiar with the historical aspects of melanoma genetics and should have a greater understanding of the CDKN2A(p16)/ARF tumor suppressor genes....
Molecular defects in both tumor suppressor genes and oncogenes have been pathogenically linked to melanoma in recent studies. ...LEAR …
CpG island methylator phenotype in colorectal cancer
Toyota M, et al. Proc Natl Acad Sci U S A 1999. PMID 10411935 Free PMC article.
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in neoplasia. ...CIMP+ tumors also have a high incidence of p16 and THBS1 methylation, and they include the majority of sporadic colorectal cancers with microsatellite instability related to hMLH1 methylation. ...
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in neop …
Overexpression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: with respect to histological subtypes and stages.
Wu MS, et al. J Gastroenterol Hepatol 1998. PMID 9570245
Mutations of the p15 and p16 tumour suppressor genes were assessed by polymerase chain reaction, Southern blotting, and direct DNA sequencing. ...The frequency of alterations of p53, c-erbB-2, and p16 was not related to sex and Helicobacter pylori infection. No correlation of genetic changes between any two genes was observed. ...
Mutations of the p15 and p16 tumour suppressor genes were assessed by polymerase chain reaction, Southern blotting, and direct …
Molecular genetics of familial cutaneous melanoma.
Haluska FG and Hodi FS. J Clin Oncol 1998 - Review. PMID 9469357
The most important of these is p16/CDKN2A. We attempted to determine the degree to which the p16/CDKN2A gene has been implicated in the development of melanoma, and to identify other genetic factors that play a role as well. METHODS: We reviewed the literature published since the isolation of p16/CDKN2A and identified 13 studies that report the status of the gene in melanoma samples and 12 reports that examine p16/CDKN2A in melanoma kindreds. ...
The most important of these is p16/CDKN2A. We attempted to determine the degree to which the p16/CDKN2A gene has been implicat …
Mutations of p16 and p15 tumor suppressor genes and replication errors contribute independently to the pathogenesis of sporadic malignant melanoma.
Matsumura Y, et al. Arch Dermatol Res 1998. PMID 9617435
Four (9.1%) homozygous deletions of both p16 and p15 genes and one point mutation (2.3%) in the p15 gene were detected among 44 primary melanoma samples. ...None of the samples showed the alteration of p16/p15 genes and the replication errors concomitantly. These results suggest that (1) the homozygous deletions of p16/p15 genes and the replication errors may occur in rather early stages of melanoma tumorigenesis, while the p16/p15 gene mutation may occur in later stages, and (2) the p16 and p15 gene mutations in sporadic malignant melanomas might not be induced by the defect in mismatch repair, implying that p16 as well as p15 gene alterations may play an important role in the pathogenesis of sporadic malignant melanomas....
Four (9.1%) homozygous deletions of both p16 and p15 genes and one point mutation (2.3%) in the p15 gene were detected among 4 …
Hereditary cutaneous melanoma
Platz A, et al. Semin Cancer Biol 2000 - Review. PMID 10966854
Genes involved in senescence and immortalization.
Lundberg AS, et al. Curr Opin Cell Biol 2000 - Review. PMID 11063935
The role of telomere maintenance in immortalization and the roles of p16(INK4A), p19(ARF), p53 and other genes in senescence are being further elucidated. ...
The role of telomere maintenance in immortalization and the roles of p16(INK4A), p19(ARF), p53 and other genes in senescence a …
Lack of sequence variation in sporadic bovine leucosis in regions of tumour suppressor genes p53 and p16.
Mayr B, et al. J Vet Med A Physiol Pathol Clin Med 2001. PMID 11554494
Exon 2 of tumour suppressor gene p16 was also investigated in the same samples. No sequence variations were present in the analysed areas of the genes. ...In p16, no comparative data are available....
Exon 2 of tumour suppressor gene p16 was also investigated in the same samples. No sequence variations were present in the analysed a …
In acute lymphoblastic leukemia deletion of the tumor suppressor gene P16 is associated with abnormal interferon genes.
Sternik G, et al. Medicina (B Aires) 1998. PMID 9922477
In 23 out of 32 ALL cases the 3 genes studied were normally preserved. In the remaining 9 ALL, p16 was affected in 8 cases by homozygous deletions. ...In the remaining 5 cases, p16 was the only gene deleted with no alteration of type I interferon genes. These data indicate that p16 gene is deleted in a higher frequency than type I interferon genes in ALL. ...
In 23 out of 32 ALL cases the 3 genes studied were normally preserved. In the remaining 9 ALL, p16 was affected in 8 cases by …
The INK4A/ARF locus and its two gene products
Sharpless NE and DePinho RA. Curr Opin Genet Dev 1999 - Review. PMID 10072356
Two genes comprising overlapping reading frames encoding p16(INK4a) and p19(ARF) have been discovered at this locus and, remarkably, both play an important role in regulating cell growth, survival and senescence....
Two genes comprising overlapping reading frames encoding p16(INK4a) and p19(ARF) have been discovered at this locus and, remar …
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