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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 2
1981 1
1984 2
1986 7
1987 51
1988 218
1989 288
1990 307
1991 377
1992 412
1993 389
1994 378
1995 386
1996 362
1997 330
1998 305
1999 266
2000 300
2001 263
2002 196
2003 219
2004 199
2005 245
2006 197
2007 185
2008 176
2009 190
2010 181
2011 181
2012 184
2013 150
2014 161
2015 116
2016 109
2017 92
2018 70
2019 22
2020 0
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7,259 results
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Page 1
A model for RAS mutation patterns in cancers: finding the sweet spot.
Li S, et al. Nat Rev Cancer 2018 - Review. PMID 30420765
The three RAS genes - HRAS, NRAS and KRAS - are collectively mutated in one-third of human cancers, where they act as prototypic oncogenes. ...As RAS genes are among the earliest, if not the first, genes mutated in a variety of cancers, understanding how these mutation patterns arise could inform on not only how cancer begins but also the factors influencing this event, which has implications for cancer prevention. ...
The three RAS genes - HRAS, NRAS and KRAS - are collectively mutated in one-third of human cancers, where they act as prototyp …
ras oncogenes in human cancer: a review.
Bos JL. Cancer Res 1989 - Review. PMID 2547513 Free article.
Mutations in codon 12, 13, or 61 of one of the three ras genes, H-ras, K-ras, and N-ras, convert these genes into active oncogenes. Rapid assays for the detection of these point mutations have been developed recently and used to investigate the role mutated ras genes play in the pathogenesis of human tumors. ...
Mutations in codon 12, 13, or 61 of one of the three ras genes, H-ras, K-ras, and N-ras, convert these …
RAS oncogenes: the first 30 years.
Malumbres M and Barbacid M. Nat Rev Cancer 2003 - Review. PMID 12778136
From the pioneering work with acute transforming retroviruses to the current post-genomic era, RAS genes have always been at the leading edge of signal transduction and molecular oncology. Yet, a complete understanding of RAS function and dysfunction - mainly in human cancer - is still to come. The knowledge that has accumulated since their discovery 30 years ago has, however, been remarkable, and should pave the way for not only solving the outstanding issues regarding RAS biology, but also for developing efficacious drugs that could have a significant impact on cancer treatment....
From the pioneering work with acute transforming retroviruses to the current post-genomic era, RAS genes have always been at t …
Ras and the Plasma Membrane: A Complicated Relationship.
Zhou Y, et al. Cold Spring Harb Perspect Med 2018 - Review. PMID 29229665 Free PMC article.
Ras nanoclusters have distinct lipid compositions as a result of lipid-sorting specificity encoded in each Ras carboxy-terminal membrane anchor. ...Modulating the formation of Ras dimers, the lipid composition of the PM or lateral dynamics of key PM phospholipids represent novel mechanisms whereby the extent of Ras nanoclustering can be regulated to tune the gain in Ras signaling circuits....
Ras nanoclusters have distinct lipid compositions as a result of lipid-sorting specificity encoded in each Ras carboxy-termina
RAS oncogenes: weaving a tumorigenic web.
Pylayeva-Gupta Y, et al. Nat Rev Cancer 2011 - Review. PMID 21993244 Free PMC article.
A wealth of biochemical and genetic studies indicates that RAS proteins control a complex molecular circuitry that consists of a wide array of interconnecting pathways. In this Review, we describe how RAS oncogenes exploit their extensive signalling reach to affect multiple cellular processes that drive tumorigenesis....
A wealth of biochemical and genetic studies indicates that RAS proteins control a complex molecular circuitry that consists of a wide …
Normal ras genes: their onco-suppressor and pro-apoptotic functions (review).
Spandidos DA, et al. Int J Oncol 2002 - Review. PMID 12118316
Ras genes are also involved in induction of senescence or apoptosis, suggesting activation of alternative pathways that may be anti-oncogenic. ...Recent development of the Kras2 deficient mice provided the tool to study the role of wild-type ras genes in tumorigenesis....
Ras genes are also involved in induction of senescence or apoptosis, suggesting activation of alternative pathways that may be
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.
Coppé JP, et al. PLoS Biol 2008 - Clinical Trial. PMID 19053174 Free PMC article.
Both loss of p53 and gain of oncogenic RAS also exacerbated the promalignant paracrine activities of the SASPs. Our findings define a central feature of genotoxic stress-induced senescence. Moreover, they suggest a cell-nonautonomous mechanism by which p53 can restrain, and oncogenic RAS can promote, the development of age-related cancer by altering the tissue microenvironment....
Both loss of p53 and gain of oncogenic RAS also exacerbated the promalignant paracrine activities of the SASPs. Our findings define a …
A comprehensive survey of Ras mutations in cancer.
Prior IA, et al. Cancer Res 2012. PMID 22589270 Free PMC article.
All mammalian cells express 3 closely related Ras proteins, termed H-Ras, K-Ras, and N-Ras, that promote oncogenesis when they are mutationally activated at codon 12, 13, or 61. Although there is a high degree of similarity among the isoforms, K-Ras mutations are far more frequently observed in cancer, and each isoform displays preferential coupling to particular cancer types. ...
All mammalian cells express 3 closely related Ras proteins, termed H-Ras, K-Ras, and N-Ras, that promote oncogen …
Targeting Ras genes in kidney disease.
Hendry BM and Sharpe CC. Nephron Exp Nephrol 2003 - Review. PMID 12759573
The specific Ras genes appear to play discrete and identifiable roles in a range of complex signalling networks. These insights lead to the possibility of targeting Ras genes in a specific manner in renal therapies. For example, the process of renal cell proliferation might be sensitive to downregulation of Harvey Ras and Kirsten Ras; targeting of Rho A and related species may modulate cell migration, fibrosis, and intrarenal vasoconstriction. ...
The specific Ras genes appear to play discrete and identifiable roles in a range of complex signalling networks. These insight …
What's new in ras genes? Physiological role of ras genes in signal transduction and significance of ras gene activation in tumorigenesis.
Waldmann V and Rabes HM. Pathol Res Pract 1996 - Review. PMID 8950754
Ras gene mutations have been found with variable prevalence in different tumor types. While during the past decade a lot of information has been accumulated on the frequency of ras oncogene activation in tumors, the last two years brought considerable progress in elucidating molecular mechanisms of signal transduction for which cellular ras proteins are key elements. ...Mutational activation of cellular ras genes to transforming oncogenes is thought to promote cell growth even in the absence of extracellular stimuli, and may thereby contribute to the initiation and/or progression of tumors....
Ras gene mutations have been found with variable prevalence in different tumor types. While during the past decade a lot of informati
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