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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 11
1947 3
1948 6
1949 4
1950 8
1951 15
1952 10
1953 10
1954 9
1955 25
1956 24
1957 26
1958 33
1959 35
1960 39
1961 32
1962 30
1963 29
1964 21
1965 23
1973 8
1974 7
1975 6
1976 10
1977 1
1978 2
1979 2
1980 7
1981 7
1982 12
1983 16
1984 24
1985 25
1986 8
1987 16
1988 33
1989 88
1990 205
1991 207
1992 319
1993 477
1994 742
1995 1016
1996 1084
1997 1282
1998 1408
1999 1751
2000 2184
2001 2257
2002 2390
2003 2429
2004 2433
2005 2626
2006 2343
2007 2198
2008 2258
2009 2097
2010 2129
2011 2176
2012 2111
2013 1953
2014 1868
2015 2118
2016 2060
2017 1920
2018 1815
2019 725
2020 12
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Search Results

48,123 results
Results by year
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Page 1
[Gene therapy – from idea to reality].
Smith CIE and Blomberg P. Lakartidningen 2017 - Review. PMID 29297925 Swedish. Free article.
Gene therapy - from idea to reality Gene therapy was originally proposed 45 years ago, but it is only during the last 5-10 years that significant clinical benefit has been demonstrated. ...Genetic therapy also includes oligonucleotides, which consist of around 20 nucleotides. Several such compounds have been approved for clinical use. ...
Gene therapy - from idea to reality Gene therapy was originally proposed 45 years ago, but it is only during the last 5-10 yea …
History of gene therapy.
Wirth T, et al. Gene 2013 - Review. PMID 23618815
Two decades after the initial gene therapy trials and more than 1700 approved clinical trials worldwide we not only have gained much new information and knowledge regarding gene therapy in general, but also learned to understand the concern that has persisted in society. ...We will also discuss briefly the safety and ethical aspects of gene therapy and address some concerns that have been connected with gene therapy as an important therapeutic modality....
Two decades after the initial gene therapy trials and more than 1700 approved clinical trials worldwide we not only have gained much …
Gene therapy.
Brody H. Nature 2018. PMID 30542191
Gene therapy on the move.
Kaufmann KB, et al. EMBO Mol Med 2013 - Review. PMID 24106209 Free PMC article.
The first gene therapy clinical trials were initiated more than two decades ago. In the early days, gene therapy shared the fate of many experimental medicine approaches and was impeded by the occurrence of severe side effects in a few treated patients. ...With more than 1900 clinical trials to date, gene therapy has moved from a vision to clinical reality. This review focuses on the application of gene therapy for the correction of inherited diseases, the limitations and drawbacks encountered in some of the early clinical trials and the revival of gene therapy as a powerful treatment option for the correction of monogenic disorders....
The first gene therapy clinical trials were initiated more than two decades ago. In the early days, gene therapy shared the fa …
CRISPR/Cas9 therapeutics: a cure for cancer and other genetic diseases.
Khan FA, et al. Oncotarget 2016 - Review. PMID 27250031 Free PMC article.
In defining its superior use, we have followed the recent advances that have been made in producing CRISPR/Cas9 as a therapy of choice. We also provide important genetic mutations where CRISPRs can be repurposed to create adaptive immunity to fight carcinomas and edit genetic mutations causing it. ...
In defining its superior use, we have followed the recent advances that have been made in producing CRISPR/Cas9 as a therapy of choic …
Gene Therapy Now?
Pederson T. FASEB J 2018. PMID 29592791
Lentiviral vectors in gene therapy: their current status and future potential.
Escors D and Breckpot K. Arch Immunol Ther Exp (Warsz) 2010 - Review. PMID 20143172 Free PMC article.
This first success, achieved after retroviral therapy, was later overshadowed by the occurrence of vector-related leukemia in a significant number of the treated children, demonstrating that the future success of gene therapy depends on our understanding of vector biology. ...Human gene therapy clinical trials are currently underway using lentivectors in a wide range of human diseases. The intention of this review is to describe the main scientific steps leading to the engineering of HIV-1 lentiviral vectors and place them in the context of current human gene therapy....
This first success, achieved after retroviral therapy, was later overshadowed by the occurrence of vector-related leukemia in a signi …
The Pharmacology of Gene Therapy.
Ylä-Herttuala S. Mol Ther 2017. PMID 28739283 Free PMC article.
Gene therapy for neurodegenerative diseases.
O'Connor DM and Boulis NM. Trends Mol Med 2015 - Review. PMID 26122838
Gene therapy is, potentially, a powerful tool for treating neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy, Parkinson's disease (PD) and Alzheimer's disease (AD). ...These improvements may finally make gene therapy successful for these disorders....
Gene therapy is, potentially, a powerful tool for treating neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), sp …
CRISPR/Cas9 gene-editing: Research technologies, clinical applications and ethical considerations
Memi F, et al. Semin Perinatol 2018 - Review. PMID 30482590
Gene therapy carries the potential to treat more than 10,000 human monogenic diseases and benefit an even greater number of complex polygenic conditions. The repurposing of CRISPR/Cas9, an ancient bacterial immune defense system, into a gene-editing technology has armed researchers with a revolutionary tool for gene therapy. ...
Gene therapy carries the potential to treat more than 10,000 human monogenic diseases and benefit an even greater number of complex p …
48,123 results
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