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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 3
1994 9
1995 33
1996 70
1997 90
1998 123
1999 130
2000 158
2001 150
2002 151
2003 193
2004 144
2005 163
2006 182
2007 167
2008 185
2009 159
2010 195
2011 168
2012 167
2013 197
2014 178
2015 165
2016 143
2017 147
2018 148
2019 59
2020 0
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3,352 results
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The reversible effects of glial cell line-derived neurotrophic factor (GDNF) in the human brain.
Ayanlaja AA, et al. Semin Cancer Biol 2018 - Review. PMID 30059726 Free article.
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor, and a member of the transforming growth factor β (TGF-β) superfamily acting on different neuronal activities. ...Collectively, our work establishes a paradigm by which the ability of GDNF to protect dopaminergic neurons from degradation and its corresponding effects on glioma cells points to an underlying biological vulnerability in the effects of GDNF in the normal brain which can be subverted for use by cancer cells. ...
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor, and a member of the transforming growth factor
Glial Cell Line-Derived Neurotrophic Factor (GDNF) Promotes Angiogenesis through the Demethylation of the Fibromodulin (FMOD) Promoter in Glioblastoma.
Chen M, et al. Med Sci Monit 2018. PMID 30176167 Free PMC article.
Previous studies have proved that glial cell line-derived neurotrophic factor (GDNF) and fibromodulin (FMOD) are strongly expressed in human glioblastoma. ...MATERIAL AND METHODS The effects of GDNF on the expression and secretion of vascular endothelial growth factor (VEGF) in human glioblastoma cell line U251 and angiogenesis in human umbilical vein endothelial cells (HUVECs) were investigated. ...
Previous studies have proved that glial cell line-derived neurotrophic factor (GDNF) and fibromodulin (FMOD) are strongly expr …
Serum glial cell line-derived neurotrophic factor levels and postoperative cognitive dysfunction after surgery for rheumatic heart disease.
Duan X, et al. J Thorac Cardiovasc Surg 2018 - Clinical Trial. PMID 28918204
Serum glial cell line-derived neurotrophic factor levels are decreased in patients with Alzheimer's disease, but the association between glial cell line-derived neurotrophic factor levels and postoperative cognitive dysfunction is poorly understood. ...Glial cell line-derived neurotrophic factor could be an effective predictor for the occurrence of postoperative cognitive dysfunction. ...
Serum glial cell line-derived neurotrophic factor levels are decreased in patients with Alzheimer's disease, but the associati …
Role of glial cell line-derived neurotrophic factor in the pathogenesis and treatment of mood disorders.
Tsybko AS, et al. Rev Neurosci 2017 - Review. PMID 28099138
Glial cell line-derived neurotrophic factor (GDNF) is widely recognized as a survival factor for dopaminergic neurons, but GDNF has also been shown to promote development, differentiation, and protection of other central nervous system neurons and was thought to play an important role in various neuropsychiatric disorders. ...
Glial cell line-derived neurotrophic factor (GDNF) is widely recognized as a survival factor for dopaminergic neurons, but GDN
The Effects of Glial Cell Line-Derived Neurotrophic Factor after Spinal Cord Injury.
Rosich K, et al. J Neurotrauma 2017 - Review. PMID 28795616
Glial cell line-derived neurotrophic factor (GDNF) is an important growth factor, because it can affect both neurons and support cells. ...Even though GDNF can be directly administered, genetically modified cells are often used as a delivery vehicle. Several different types of genetically modified cells have been used with varying success. ...
Glial cell line-derived neurotrophic factor (GDNF) is an important growth factor, because it can affect both neurons and suppo
Spinal glial cell line-derived neurotrophic factor infusion reverses reduction of Kv4.1-mediated A-type potassium currents of injured myelinated primary afferent neurons in a neuropathic pain model.
Shinoda M, et al. Mol Pain 2019. PMID 30868936 Free PMC article.
L5 spinal nerve ligation significantly reduced the current density of I(A) and glial cell line-derived neurotrophic factor treatment reversed the reduction. ...These findings suggest that glial cell line-derived neurotrophic factor should reduce the hyperexcitability of injured A-fiber primary afferents by I(A) recurrence. ...
L5 spinal nerve ligation significantly reduced the current density of I(A) and glial cell line-derived neurotrophic factor tre …
Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis.
Thomsen GM, et al. Stem Cells 2018. PMID 29656478 Free article.
In the current study, human cortical-derived neural progenitor cells engineered to secrete glial cell line-derived neurotrophic factor (GDNF) were transplanted into the SOD1(G93A) ALS rat cortex, where they migrated, matured into astrocytes, and released GDNF. ...Stem Cells 2018;36:1122-1131....
In the current study, human cortical-derived neural progenitor cells engineered to secrete glial cell line-derived neur …
Glial cell line-derived neurotrophic factor supplementation promotes bovine in vitro oocyte maturation and early embryo development.
Wang DH, et al. Theriogenology 2018. PMID 29477014
Paracrine factors such as glial cell line-derived neurotrophic factor (GDNF), which was originally derived from the supernatants of a rat glioma cell line, play pivotal roles in oocyte maturation and early embryo development in mammals, such as mice, rats, pigs, sheep, and even humans. ...
Paracrine factors such as glial cell line-derived neurotrophic factor (GDNF), which was originally derived from the supernatan …
High Concentration of Glial Cell Line-Derived Neurotrophic Factor Protects Primary Astrocytes from Apoptosis.
Wang Y, et al. Dev Neurosci 2018. PMID 29656289
Glial cell line-derived neurotrophic factor (GDNF) has always been considered a protective factor for dopamine neurons. However, it remains unclear whether GDNF has a protective effect on glial cells, especially astrocytes. ...The cell viability, cell nucleus morphology, and apoptosis ratio of the cells was assessed by Hoechst 33342 staining, CCK-8 assay, and flow cytometry assay, respectively. ...
Glial cell line-derived neurotrophic factor (GDNF) has always been considered a protective factor for dopamine neurons. Howeve
Glial cell line-derived neurotrophic factor (GDNF) counteracts hypoxic damage to hippocampal neural network function in vitro.
Shishkina TV, et al. Brain Res 2018. PMID 29106947 Free article.
Glial cell line-derived neurotrophic factor (GDNF) is regarded as a potent neuroprotector and a corrector of neural network activity in stress conditions. ...Intravital mRNA detection identified fewer GluR2 mRNA-positive cells, whereas GDNF preserved the number of these cells in the post-hypoxic period. ...
Glial cell line-derived neurotrophic factor (GDNF) is regarded as a potent neuroprotector and a corrector of neural network ac
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