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2005 6
2006 17
2007 18
2008 15
2009 18
2010 16
2011 13
2012 11
2013 21
2014 18
2015 24
2016 18
2017 12
2018 19
2019 7
2020 0
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205 results
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The reversible effects of glial cell line-derived neurotrophic factor (GDNF) in the human brain.
Ayanlaja AA, et al. Semin Cancer Biol 2018 - Review. PMID 30059726 Free article.
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor, and a member of the transforming growth factor β (TGF-β) superfamily acting on different neuronal activities. ...Collectively, our work establishes a paradigm by which the ability of GDNF to protect dopaminergic neurons from degradation and its corresponding effects on glioma cells points to an underlying biological vulnerability in the effects of GDNF in the normal brain which can be subverted for use by cancer cells. ...
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor, and a member of the transforming growth factor
Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling.
Tao L, et al. Gut 2019. PMID 31171625 Free PMC article.
OBJECTIVE: Although glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor-β superfamily, its function in liver fibrosis has rarely been studied. Here, we investigated the role of GDNF in hepatic stellate cell (HSC) activation and liver fibrosis in humans and mice. DESIGN: GDNF expression was examined in liver biopsies and sera from patients with liver fibrosis. ...
OBJECTIVE: Although glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor-β superfa …
Glial cell line-derived neurotrophic factor promotes proliferation of neuroglioma cells by up-regulation of cyclins PCNA and Ki-67.
Qu DW, et al. Eur Rev Med Pharmacol Sci 2015. PMID 26125271 Free article.
OBJECTIVE: We wished to test whether glial cell line-derived neurotrophic factor (GDNF) stimulates proliferation of gliomas by up-regulating expression of nuclear cyclins PCNA and Ki37. ...Using this concentration and incubation time, we next documented that GDNF increased the percentage of cells in the S phase (47.98% vs. 32.57% in basal cells; p < 0.05), while not affecting the percentage of cells in G0/G1 or G2/M phases. ...
OBJECTIVE: We wished to test whether glial cell line-derived neurotrophic factor (GDNF) stimulates proliferation of gliomas by …
Glial cell-derived neurotrophic factor gene polymorpisms affect severity and functionality of bipolar disorder.
Safari R, et al. J Integr Neurosci 2017. PMID 28891527
Glial cell-derived neurotrophic factor and other neurotrophins have important role in the development of mental disorders. Here, we aimed to assess the effects of Single nucleotide polymorphisms at potentially regulated regions of GDNF on severity and functionality of bipolar disorder and GDNF serum levels in bipolar disorder patients and healthy volunteers. ...
Glial cell-derived neurotrophic factor and other neurotrophins have important role in the development of mental disorders. Her
Glial cell line-derived neurotrophic factor induced the differentiation of amniotic fluid-derived stem cells into vascular endothelial-like cells in vitro.
Zhang R, et al. J Mol Histol 2016. PMID 26712153
Amniotic fluid-derived stem cells (AFSCs) are a novel source of stem cells that are isolated and cultured from second trimester amniocentesis. Glial cell line-derived neurotrophic factor (GDNF) acts as a tissue morphogen and regulates stem cell proliferation and differentiation. ...
Amniotic fluid-derived stem cells (AFSCs) are a novel source of stem cells that are isolated and cultured from second trimeste …
The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells.
Abe H, et al. Biochem Biophys Res Commun 2016. PMID 27678293
Neurotrophic/growth factors derived from glial cells, especially astrocytes, have been implicated in mood disorders and the pharmacological effects of antidepressant drugs. Previous studies demonstrated that the release of glial cell line-derived neurotrophic factor (GDNF) induced by the tricyclic antidepressant amitriptyline was significantly inhibited by a broad-spectrum matrix metalloproteinase (MMP) inhibitor in rat C6 astroglial cells (C6 cells). ...
Neurotrophic/growth factors derived from glial cells, especially astrocytes, have been implicated in mood disorders and the ph …
MicroRNA regulation of central glial cell line-derived neurotrophic factor (GDNF) signalling in depression.
Maheu M, et al. Transl Psychiatry 2015. PMID 25689572 Free PMC article.
Although multiple studies have reported that peripheral glial cell line-derived neurotrophic factor (GDNF) is reduced in depression, cerebral GDNF signalling has yet to be examined in this condition. ...Transfection of human neural progenitor cells (NPCs) with a miR-511 mimic was sufficient to repress GFRA1-L/GFRα1a without altering GFRα1b, and resulted in pathway-specific changes in immediate early gene activity. ...
Although multiple studies have reported that peripheral glial cell line-derived neurotrophic factor (GDNF) is reduced in depre …
Association between smoking behaviour and genetic variants of glial cell line-derived neurotrophic factor.
Kotyuk E, et al. J Genet 2016. PMID 27994179 Free article.
Glial cell line-derived neurotrophic factor (GDNF) promotes development and differentiation of dopaminergic neurons, thus it has an important role in dopamine-related neuropsychiatric disorders. ...
Glial cell line-derived neurotrophic factor (GDNF) promotes development and differentiation of dopaminergic neurons, thus it h
Relationship Between Chronic Tinnitus and Glial Cell Line-Derived Neurotrophic Factor Gene rs3812047, rs1110149, and rs884344 Polymorphisms in a Turkish Population.
Orenay-Boyacioglu S, et al. Biochem Genet 2016. PMID 27180191
Glial cell line-derived neurotrophic factor (GDNF) plays a key role in early development of central auditory pathway and the inner ear. ...
Glial cell line-derived neurotrophic factor (GDNF) plays a key role in early development of central auditory pathway and the i
Glial cell line-derived neurotrophic factor gene delivery via a polyethylene imine grafted chitosan carrier.
Peng YS, et al. Int J Nanomedicine 2014. PMID 25061293 Free PMC article.
Direct intracerebral injections of high doses of recombinant glial cell line-derived neurotrophic factor (GDNF) have been shown to protect adult nigral dopaminergic neurons. ...
Direct intracerebral injections of high doses of recombinant glial cell line-derived neurotrophic factor (GDNF) have been show …
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