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Year Number of Results
2002 1
2003 1
2004 4
2005 34
2006 87
2007 101
2008 111
2009 93
2010 116
2011 113
2012 109
2013 130
2014 122
2015 104
2016 88
2017 106
2018 92
2019 40
2020 0
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1,249 results
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Page 1
Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease.
Whone A, et al. Brain 2019 - Clinical Trial. PMID 30808022 Free PMC article.
We investigated the effects of glial cell line-derived neurotrophic factor (GDNF) in Parkinson's disease, using intermittent intraputamenal convection-enhanced delivery via a skull-mounted transcutaneous port as a novel administration paradigm to potentially afford putamen-wide therapeutic delivery. ...
We investigated the effects of glial cell line-derived neurotrophic factor (GDNF) in Parkinson's disease, using intermittent i …
Glial cell line-derived neurotrophic factor in genetically defined fear-induced aggression.
Ilchibaeva TV, et al. Eur J Neurosci 2016. PMID 27519646
Glial cell line-derived neurotrophic factor (GDNF) plays an important role in maintenance of neuronal system throughout life. ...
Glial cell line-derived neurotrophic factor (GDNF) plays an important role in maintenance of neuronal system throughout life.
Spinal glial cell line-derived neurotrophic factor infusion reverses reduction of Kv4.1-mediated A-type potassium currents of injured myelinated primary afferent neurons in a neuropathic pain model.
Shinoda M, et al. Mol Pain 2019. PMID 30868936 Free PMC article.
L5 spinal nerve ligation significantly reduced the current density of I(A) and glial cell line-derived neurotrophic factor treatment reversed the reduction. ...These findings suggest that glial cell line-derived neurotrophic factor should reduce the hyperexcitability of injured A-fiber primary afferents by I(A) recurrence. ...
L5 spinal nerve ligation significantly reduced the current density of I(A) and glial cell line-derived neurotrophic factor tre …
Role of glial cell line-derived neurotrophic factor in the pathogenesis and treatment of mood disorders.
Tsybko AS, et al. Rev Neurosci 2017 - Review. PMID 28099138
Glial cell line-derived neurotrophic factor (GDNF) is widely recognized as a survival factor for dopaminergic neurons, but GDNF has also been shown to promote development, differentiation, and protection of other central nervous system neurons and was thought to play an important role in various neuropsychiatric disorders. ...
Glial cell line-derived neurotrophic factor (GDNF) is widely recognized as a survival factor for dopaminergic neurons, but GDN
The glial cell-line derived neurotrophic factor: a novel regulator of intestinal barrier function in health and disease.
Meir M, et al. Am J Physiol Gastrointest Liver Physiol 2016 - Review. PMID 27151942 Free article.
Recent data provide evidence that the glial cell line-derived neurotrophic factor (GDNF) is critically involved in intestinal epithelial wound healing and barrier maturation and exerts antiapoptotic effects under certain conditions. ...
Recent data provide evidence that the glial cell line-derived neurotrophic factor (GDNF) is critically involved in intestinal …
Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis.
Thomsen GM, et al. Stem Cells 2018. PMID 29656478 Free article.
In the current study, human cortical-derived neural progenitor cells engineered to secrete glial cell line-derived neurotrophic factor (GDNF) were transplanted into the SOD1(G93A) ALS rat cortex, where they migrated, matured into astrocytes, and released GDNF. ...Stem Cells 2018;36:1122-1131....
In the current study, human cortical-derived neural progenitor cells engineered to secrete glial cell line-derived neur …
APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation.
Stanga S, et al. FASEB J 2016. PMID 26718890
These defects are rescued by GDNF expression in muscle cells in the conditions where muscular APP has been previously silenced. ...APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation....
These defects are rescued by GDNF expression in muscle cells in the conditions where muscular APP has been previously silenced. ...AP …
Altered serum levels of glial cell line-derived neurotrophic factor in male chronic schizophrenia patients with tardive dyskinesia.
Ye F, et al. Int J Methods Psychiatr Res 2018. PMID 29901253 Free PMC article.
Glial cell line-derived neurotrophic factor (GDNF) is a critical role in the protection of catecholaminergic, dopaminergic, and cholinergic neurons. ...
Glial cell line-derived neurotrophic factor (GDNF) is a critical role in the protection of catecholaminergic, dopaminergic, an
Pretreatment of glial cell-derived neurotrophic factor and geranylgeranylacetone ameliorates brain injury in Parkinson's disease by its anti-apoptotic and anti-oxidative property.
Yue P, et al. J Cell Biochem 2018. PMID 29377238
The aim of the present study was to determine the combined effects of glial cell-derived neurotrophic factor (GDNF) and geranylgeranylacetone (GGA) on neuron apoptosis and oxidative stress in Parkinson's disease (PD). A mouse MPTP model of PD and cellular models of H(2) O(2) and MPP(+) -treated PC12 cells were established. Swimming, pole, and traction tests were used to detect behavioral impairment. ...
The aim of the present study was to determine the combined effects of glial cell-derived neurotrophic factor (GDNF) and gerany …
The production of glial cell line-derived neurotrophic factor by human sertoli cells is substantially reduced in sertoli cell-only testes.
Singh D, et al. Hum Reprod 2017. PMID 28369535 Free PMC article.
STUDY QUESTION: Do human Sertoli cells in testes that exhibit the Sertoli cell-only (SCO) phenotype produce substantially less glial cell line-derived neurotrophic factor (GDNF) than Sertoli cells in normal testes? ...As controls, we also measured transcripts encoding two other Sertoli cell products, kit ligand (KITL) and clusterin (CLU). Finally, we compared the amounts of GDNF per Sertoli cell in normal and SCO testes. ...
STUDY QUESTION: Do human Sertoli cells in testes that exhibit the Sertoli cell-only (SCO) phenotype produce substantially less …
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