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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 22
1946 82
1947 104
1948 119
1949 149
1950 190
1951 209
1952 261
1953 322
1954 300
1955 295
1956 319
1957 277
1958 361
1959 339
1960 374
1961 420
1962 517
1963 902
1964 1553
1965 1305
1966 1397
1967 1788
1968 2274
1969 2415
1970 2463
1971 2918
1972 2940
1973 3041
1974 3110
1975 2689
1976 2337
1977 2101
1978 1862
1979 1938
1980 1915
1981 1869
1982 1888
1983 1881
1984 2015
1985 2140
1986 2061
1987 1902
1988 2001
1989 2072
1990 2236
1991 2263
1992 2154
1993 2307
1994 2382
1995 2412
1996 2358
1997 2447
1998 2397
1999 2331
2000 2439
2001 2766
2002 2836
2003 3008
2004 3157
2005 3314
2006 3404
2007 3544
2008 3712
2009 4003
2010 4115
2011 4391
2012 4731
2013 4994
2014 4852
2015 4873
2016 4922
2017 5031
2018 4714
2019 2391
2020 53
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152,742 results
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A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila.
Oh Y, et al. Nature 2019. PMID 31645735 Free PMC article.
Although glucose-sensing neurons were identified more than 50 years ago, the physiological role of glucose sensing in metazoans remains unclear. ...We propose that these glucose-sensing neurons maintain glucose homeostasis by promoting the secretion of dilp2 and suppressing the release of AKH when haemolymph glucose levels are high....
Although glucose-sensing neurons were identified more than 50 years ago, the physiological role of glucose sensing in metazoan …
Advanced biosensors for glucose and insulin.
Sabu C, et al. Biosens Bioelectron 2019 - Review. PMID 31302426
Among them, the estimation of blood glucose concentration is one of the main diagnostic criteria. Proper control of the blood glucose level can delay, and to a greater extent, prevent complications. Thus, blood glucose monitoring is a requisite tool in the management of diabetes mellitus. Insulin plays a major role in glucose metabolism and its determination is of great value in the diagnosis and control of diabetes. ...
Among them, the estimation of blood glucose concentration is one of the main diagnostic criteria. Proper control of the blood gluc
LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc.
Tang J, et al. Nat Commun 2019. PMID 31375671 Free PMC article.
However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under glucose starvation in CRC cells, supporting cell survival and proliferation by enhancing glycolysis. ...
However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a l …
Glucose and glycogen in the diabetic kidney: Heroes or villains?
Sullivan MA and Forbes JM. EBioMedicine 2019 - Review. PMID 31405756 Free PMC article.
However, these exciting data have come with the puzzling but fascinating paradigm that many of the beneficial effects on the kidney and cardiovascular system seem to be independent of the systemic glucose lowering actions of these agents. This manuscript places into context an area of research highly relevant to renal glucose metabolism, that of glycogen accumulation and metabolism in the diabetic kidney. ...
However, these exciting data have come with the puzzling but fascinating paradigm that many of the beneficial effects on the kidney and card …
Control of Translation at the Initiation Phase During Glucose Starvation in Yeast.
Janapala Y, et al. Int J Mol Sci 2019 - Review. PMID 31430885 Free PMC article.
Glucose is one of the most important sources of carbon across all life. Glucose starvation is a key stress relevant to all eukaryotic cells. Glucose starvation responses have important implications in diseases, such as diabetes and cancer. In yeast, glucose starvation causes rapid and dramatic effects on the synthesis of proteins (mRNA translation). ...
Glucose is one of the most important sources of carbon across all life. Glucose starvation is a key stress relevant to all euk
TRPV1 Mediates Glucose-induced Insulin Secretion Through Releasing Neuropeptides.
Zhong B, et al. In Vivo 2019. PMID 31471389 Free PMC article.
Glucose tolerance and insulin secretion were measured at the end of the experiments. RESULTS: TRPV1(-/-) mice had greater impairments in glucose tolerance and higher decrease in glucose-induced insulin secretion than WT mice. ...Glucose-induced SP and CGRP release from WT pancreas was higher than that from TRPV1(-/-) pancreas. CONCLUSION: TRPV1 mediates glucose-induced insulin secretion likely through CGRP and SP release....
Glucose tolerance and insulin secretion were measured at the end of the experiments. RESULTS: TRPV1(-/-) mice had greater impairments
Postprandial metabolic effects of fructose and glucose in type 1 diabetes patients: a pilot randomized crossover clinical trial.
Souto DL, et al. Arch Endocrinol Metab 2019 - Clinical Trial. PMID 31365624 Free article.
OBJECTIVE: To test the influence of oral fructose and glucose dose-response solutions in blood glucose (BG), glucagon, triglycerides, uricaemia, and malondialdehyde in postprandial states in type 1 diabetes mellitus (T1DM) patients. ...Fructose resulted in lower postprandial BG levels than glucose (4.4 ± 5.5 mmol/L; and 12.9 ± 4.1 mmol/L, respectively; p < 0.01). ...
OBJECTIVE: To test the influence of oral fructose and glucose dose-response solutions in blood glucose (BG), glucagon, triglyc …
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.
Liu J, et al. Nat Commun 2019. PMID 31197173 Free PMC article.
We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analyses highlight the role of differential methylation in the crosstalk between the adaptive immune system and glucose homeostasis. ...
We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the …
Effects of high glucose on proliferation and function of circulating fibrocytes: Involvement of CXCR4/SDF‑1 axis.
Weng Y, et al. Int J Mol Med 2019. PMID 31257476 Free PMC article.
Flow cytometry revealed that 30 mmol/l glucose significantly promoted the expression of COL‑I vs. 5.5 mmol/l glucose group (P<0.01), while AMD3100 reversed this (P<0.05). ...While AMD3100 reversed the cell migratory effects induced by high glucose (P<0.01). In addition, the secretion of SDF‑1 stimulated by 30 mmol/l glucose DMEM showed no differences compared with 5.5 mmol/l glucose DMEM (P>0.05). ...
Flow cytometry revealed that 30 mmol/l glucose significantly promoted the expression of COL‑I vs. 5.5 mmol/l glucose group (P& …
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