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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 2
1947 8
1948 15
1949 3
1951 47
1952 103
1953 124
1954 123
1955 162
1956 136
1957 116
1958 173
1959 174
1960 190
1961 229
1962 161
1963 15
1964 444
1965 725
1966 880
1967 1068
1968 1348
1969 1377
1970 1498
1971 1718
1972 1860
1973 2007
1974 2262
1975 2140
1976 1937
1977 1894
1978 1763
1979 1839
1980 1929
1981 2031
1982 1946
1983 2017
1984 2233
1985 2384
1986 2283
1987 2300
1988 2284
1989 2264
1990 2537
1991 2637
1992 2589
1993 2757
1994 2749
1995 2796
1996 2780
1997 2834
1998 2759
1999 2807
2000 2935
2001 3058
2002 3285
2003 3461
2004 3669
2005 4073
2006 4371
2007 4754
2008 5329
2009 5755
2010 5692
2011 5852
2012 6573
2013 7011
2014 7008
2015 6821
2016 6663
2017 6706
2018 6114
2019 2689
2020 29
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164,787 results
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Page 1
Sodium-glucose cotransport.
Poulsen SB, et al. Curr Opin Nephrol Hypertens 2015 - Review. PMID 26125647 Free PMC article.
PURPOSE OF REVIEW: Sodium-glucose cotransporters (SGLTs) are important mediators of glucose uptake across apical cell membranes. SGLT1 mediates almost all sodium-dependent glucose uptake in the small intestine, while in the kidney SGLT2, and to a lesser extent SGLT1, account for more than 90% and nearly 3%, respectively, of glucose reabsorption from the glomerular ultrafiltrate. ...
PURPOSE OF REVIEW: Sodium-glucose cotransporters (SGLTs) are important mediators of glucose uptake across apical cell membrane …
Cooperation between brain and islet in glucose homeostasis and diabetes.
Schwartz MW, et al. Nature 2013 - Review. PMID 24201279 Free PMC article.
However, insulin-independent mechanisms, referred to as 'glucose effectiveness', account for roughly 50% of overall glucose disposal, and reduced glucose effectiveness also contributes importantly to diabetes pathogenesis. ...Here we present evidence of a brain-centred glucoregulatory system (BCGS) that can lower blood glucose levels via both insulin-dependent and -independent mechanisms, and propose a model in which complex and highly coordinated interactions between the BCGS and pancreatic islets promote normal glucose homeostasis. ...
However, insulin-independent mechanisms, referred to as 'glucose effectiveness', account for roughly 50% of overall glucose di …
Integration of biochemical and physiologic effects of insulin on glucose metabolism.
Newsholme EA and Dimitriadis G. Exp Clin Endocrinol Diabetes 2001 - Review. PMID 11460564
The major effects of insulin on tissues are: (1) Carbohydrate metabolism: (a) It increases the rate of transport of glucose across the cell membrane in adipose tissue and muscle, (b) it increases the rate of glycolysis in muscle and adipose tissue, (c) it stimulates the rate of glycogen synthesis in a number of tissues, including adipose tissue, muscle, and liver. It also decreases the rate of glycogen breakdown in muscle and liver, (d) it inhibits the rate of glycogenolysis and gluconeogenesis in the liver. (2) Lipid metabolism: (a) It decreases the rate of lipolysis in adipose tissue and hence lowers the plasma fatty acid level, (b) it stimulates fatty acid and triacylglycerol synthesis in tissues, although only to a minor extent in humans, (c) it increases the rate of very-low-density lipoprotein formation in the liver, (d) it increases the uptake of triglyceride from the blood into adipose tissue and muscle, (e) it decreases the rate of fatty acid oxidation in muscle and liver, (f) it increases the rate of cholesterol synthesis in liver. (3) Protein metabolism: (a) It increases the rate of transport of some amino acids into tissues, (b) it increases the rate of protein synthesis in muscle, adipose tissue, liver, and other tissues, (c) it decreases the rate of protein degradation in muscle (and perhaps other tissues), (d) it decreases the rate of urea formation....
The major effects of insulin on tissues are: (1) Carbohydrate metabolism: (a) It increases the rate of transport of glucose ac …
Entosis Is Induced by Glucose Starvation.
Hamann JC, et al. Cell Rep 2017. PMID 28683313 Free PMC article.
Here, we find that entosis is induced in adherent cells by glucose withdrawal. Glucose withdrawal leads to a bimodal distribution of cells based on their deformability, where stiffer cells appear in a manner requiring the energy-sensing AMP-activated protein kinase (AMPK). ...
Here, we find that entosis is induced in adherent cells by glucose withdrawal. Glucose withdrawal leads to a bimodal distribut …
Glucose metabolism in man: responses to intravenous glucose infusion.
Wolfe RR, et al. Metabolism 1979. PMID 763155
We have determined the effect of unlabeled glucose infusions, with and without added insulin, on glucose metabolism in normal male volunteers by means of the simultaneous primed-constant infusion of 6-3H and U-13C-glucose. ...The control of plasma glucose concentration during the glucose infusion was achieved primarily through regulation of endogenous Ra. ...
We have determined the effect of unlabeled glucose infusions, with and without added insulin, on glucose metabolism in …
Role of orexins in the central and peripheral regulation of glucose homeostasis: Evidences & mechanisms.
Rani M, et al. Neuropeptides 2018 - Review. PMID 29472002
The autonomic nervous system plays an important regulatory role in the energy metabolism as well as glucose homeostasis. Orexin neurons are also under the control of GABAergic neurons. Emerging preclinical as well as clinical research has reported the role of orexins in the glucose homeostasis since orexins are involved in hypothalamic metabolism circuitry and also rely on sensing peripheral metabolic signals such as gut, adipose derived and pancreatic peptides. ...
The autonomic nervous system plays an important regulatory role in the energy metabolism as well as glucose homeostasis. Orexi …
Altered brain glucose metabolism in transgenic-PFKL mice with elevated L-phosphofructokinase: in vivo NMR studies.
Peled-Kamar M, et al. Brain Res 1998. PMID 9813288
However, unlike the slower rate of glucose metabolism in blood, the initial rate of glucose utilization in the brain of the transgenic mice, was 58% faster than in control ntg mice. This was determined by infusion of [1-13C]-glucose followed by in vivo nuclear magnetic resonance (NMR) measurements of brain glucose metabolism. ...
However, unlike the slower rate of glucose metabolism in blood, the initial rate of glucose utilization in the brain of …
Glucose transport and metabolism in the brain.
Robinson PJ and Rapoport SI. Am J Physiol 1986. PMID 3942246
A model is proposed for the uptake and metabolism of cold and radiotracer glucose that takes into account the concentration profiles of the cold and tracer glucose as they pass through the capillary bed of the brain. ...At lower glucose levels, transport of glucose across the blood-brain barrier becomes a progressively more important factor in determining uptake. ...
A model is proposed for the uptake and metabolism of cold and radiotracer glucose that takes into account the concentration pr …
Postprandial Glucose Surges after Extremely Low Carbohydrate Diet in Healthy Adults.
Kanamori K, et al. Tohoku J Exp Med 2017 - Clinical Trial. PMID 28924074 Free article.
Here, we report that extreme carbohydrate restriction for one day affects the subsequent blood glucose levels in healthy adults. ...On D2 and D4, we calculated the mean 24-hr blood glucose level (MEAN/24h) and its standard deviation (SD/24h), the area under the curve (AUC) for glucose over 140 mg/dL within 4 hours after each meal (AUC/4h/140), the mean amplitude of the glycemic excursions (MAGE), the incremental AUC of 24-hr blood glucose level above the mean plus one standard deviation (iAUC/MEAN+SD). ...
Here, we report that extreme carbohydrate restriction for one day affects the subsequent blood glucose levels in healthy adults. ...O …
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