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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 4
1946 12
1947 21
1948 43
1949 41
1950 35
1951 49
1952 46
1953 80
1954 75
1955 101
1956 101
1957 86
1958 81
1959 86
1960 59
1961 71
1962 124
1963 219
1964 433
1965 333
1966 332
1967 399
1968 539
1969 548
1970 598
1971 666
1972 697
1973 689
1974 735
1975 484
1976 395
1977 405
1978 320
1979 324
1980 338
1981 310
1982 263
1983 267
1984 246
1985 263
1986 273
1987 267
1988 323
1989 436
1990 478
1991 537
1992 494
1993 576
1994 577
1995 598
1996 613
1997 625
1998 684
1999 647
2000 650
2001 733
2002 695
2003 830
2004 901
2005 994
2006 866
2007 907
2008 900
2009 814
2010 808
2011 854
2012 882
2013 850
2014 781
2015 769
2016 796
2017 781
2018 788
2019 428
2020 19
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32,358 results
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Page 1
Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases.
Alves A, et al. Nutrients 2019 - Review. PMID 31208147 Free PMC article.
Glycine is the proteinogenic amino-acid of lowest molecular weight, harboring a hydrogen atom as a side-chain. In addition to being a building-block for proteins, glycine is also required for multiple metabolic pathways, such as glutathione synthesis and regulation of one-carbon metabolism. ...The present review aims at synthesizing the recent advances in glycine metabolism, pinpointing its main metabolic pathways, identifying the causes leading to glycine deficiency-especially in obesity and associated metabolic disorders-and evaluating the potential benefits of increasing glycine availability to curb the progression of obesity and obesity-related metabolic disturbances. ...
Glycine is the proteinogenic amino-acid of lowest molecular weight, harboring a hydrogen atom as a side-chain. In addition to being a
Assessing the causal association of glycine with risk of cardio-metabolic diseases.
Wittemans LBL, et al. Nat Commun 2019. PMID 30837465 Free PMC article.
Evidence for a genetic association of glycine with T2D is weaker, but we find a strong inverse genetic effect of hyperinsulinaemia on glycine. Our findings strengthen evidence for a protective effect of glycine on CHD and show that the glycine-T2D association may be driven by a glycine-lowering effect of insulin resistance....
Evidence for a genetic association of glycine with T2D is weaker, but we find a strong inverse genetic effect of hyperinsulinaemia on …
Unmasking GluN1/GluN3A excitatory glycine NMDA receptors.
Grand T, et al. Nat Commun 2018. PMID 30425244 Free PMC article.
GluN3A and GluN3B are glycine-binding subunits belonging to the NMDA receptor (NMDAR) family that can assemble with the GluN1 subunit to form unconventional receptors activated by glycine alone. ...Our work opens new perspectives on the exploration of excitatory glycine receptors in brain function and development....
GluN3A and GluN3B are glycine-binding subunits belonging to the NMDA receptor (NMDAR) family that can assemble with the GluN1 subunit …
Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion.
Liu YJ, et al. PLoS Genet 2019. PMID 30845140 Free PMC article.
Glycine, in contrast, substantially accumulates in aging C. elegans. In this study we show that this is coupled to a decrease in gene expression of enzymes important for glycine catabolism. ...Moreover, supplementation of glycine ameliorates specific transcriptional changes that are associated with aging. Glycine feeds into the methionine cycle. ...
Glycine, in contrast, substantially accumulates in aging C. elegans. In this study we show that this is coupled to a decrease in gene
Roxadustat: First Global Approval
Dhillon S. Drugs 2019 - Review. PMID 30805897
Glycine Induces Migration of Microglial BV-2 Cells via SNAT-Mediated Cell Swelling.
Kittl M, et al. Cell Physiol Biochem 2018. PMID 30359963 Free article.
During phagocytosis, glycine contributes to (local) cell volume-dependent processes like lamellipodium formation. Similar to the expansion of the lamellipodium we assume that glycine also affects the migration of microglial cells in a cell volume-dependent manner. ...The cell membrane potential (Vmem) displayed a distinctive time course after glycine application; initially, glycine evoked a rapid depolarization mediated by Na+-coupled glycine uptake via SNAT, followed by a further gradual depolarization, which was fully suppressed by DCPIB. ...
During phagocytosis, glycine contributes to (local) cell volume-dependent processes like lamellipodium formation. Similar to the expa …
Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-κB p65/Hif-1α Signaling Pathway.
Liu R, et al. J Immunol 2019. PMID 30710045
Glycine is a simple nonessential amino acid known to have neuroprotective properties. Treatment with glycine results in reduced infarct volume of the brain, neurologic function scores, and neuronal and microglial death in ischemic stroke injury. ...However, the role of glycine in neuroinflammation following ischemic stroke is unclear. The present study aimed to determine whether neuroinflammation is involved in the neuroprotective effects of glycine in cerebral ischemia injury. ...
Glycine is a simple nonessential amino acid known to have neuroprotective properties. Treatment with glycine results in reduce
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