Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1787 1
1789 1
1792 1
1800 1
1801 5
1802 3
1803 1
1804 2
1805 1
1806 1
1807 3
1808 1
1810 2
1811 1
1814 1
1815 1
1816 1
1817 2
1818 2
1819 1
1820 2
1821 2
1822 1
1823 3
1826 4
1828 1
1829 4
1830 1
1831 7
1832 1
1838 1
1840 5
1841 2
1842 2
1843 6
1844 9
1845 1
1846 4
1847 7
1848 2
1849 2
1851 2
1852 8
1853 4
1854 3
1855 7
1856 5
1857 9
1858 5
1859 6
1860 7
1861 4
1862 4
1863 1
1864 1
1865 4
1866 2
1867 10
1868 8
1869 7
1870 19
1871 7
1872 11
1873 13
1874 15
1875 9
1876 7
1877 12
1878 4
1879 5
1880 12
1881 19
1882 14
1883 11
1884 8
1885 10
1886 8
1887 16
1888 16
1889 20
1890 28
1891 17
1892 18
1893 15
1894 17
1895 17
1896 13
1897 15
1898 22
1899 24
1900 28
1901 23
1902 47
1903 54
1904 36
1905 44
1906 29
1907 28
1908 38
1909 69
1910 35
1911 51
1912 43
1913 36
1914 47
1915 49
1916 38
1917 19
1918 18
1919 20
1920 25
1921 28
1922 36
1923 41
1924 37
1925 49
1926 46
1927 43
1928 49
1929 57
1930 56
1931 51
1932 52
1933 40
1934 57
1935 67
1936 64
1937 56
1938 66
1939 55
1940 39
1941 50
1942 31
1943 30
1944 29
1945 423
1946 1475
1947 1979
1948 2310
1949 2120
1950 2432
1951 2494
1952 2237
1953 2147
1954 2110
1955 2338
1956 2349
1957 2311
1958 2209
1959 2203
1960 2380
1961 2458
1962 2571
1963 3097
1964 3496
1965 3266
1966 3105
1967 3436
1968 3701
1969 3695
1970 3922
1971 3925
1972 4346
1973 4409
1974 4884
1975 5977
1976 6539
1977 7171
1978 7884
1979 8234
1980 8760
1981 9166
1982 9627
1983 10612
1984 11581
1985 12282
1986 13037
1987 15124
1988 18415
1989 20724
1990 22191
1991 21850
1992 23389
1993 24642
1994 26907
1995 27418
1996 29585
1997 31000
1998 32753
1999 35271
2000 38483
2001 39994
2002 42686
2003 46427
2004 51113
2005 56715
2006 60914
2007 66359
2008 71516
2009 76739
2010 86310
2011 96138
2012 106976
2013 116856
2014 134537
2015 147213
2016 153920
2017 161066
2018 169980
2019 182818
2020 210806
2021 230333
2022 226983
2023 218263
2024 177299
2025 133

Text availability

Article attribute

Article type

Publication date

Search Results

3,170,781 results

Results by year

Filters applied: . Clear all
Page 1
An Insight into GPCR and G-Proteins as Cancer Drivers.
Chaudhary PK, Kim S. Chaudhary PK, et al. Cells. 2021 Nov 24;10(12):3288. doi: 10.3390/cells10123288. Cells. 2021. PMID: 34943797 Free PMC article. Review.
Integration of these intricate networks of signaling cascades leads to numerous biochemical responses involved in diverse pathophysiological activities, including cancer development. While several studies indicate the role of GPCRs in controlling various aspects of canc …
Integration of these intricate networks of signaling cascades leads to numerous biochemical responses involved in diverse pathophysiological …
GPCR-Hippo Signaling in Cancer.
Luo J, Yu FX. Luo J, et al. Cells. 2019 May 8;8(5):426. doi: 10.3390/cells8050426. Cells. 2019. PMID: 31072060 Free PMC article. Review.
Through the activation related G proteins and possibly rearrangements of actin cytoskeleton, GPCR signaling can potently modulate the phosphorylation states and activity of YAP and TAZ, two homologous oncogenic transcriptional co-activators, and major effectors of the Hipp …
Through the activation related G proteins and possibly rearrangements of actin cytoskeleton, GPCR signaling can potently modulate the …
Editorial: GPCR in Inflammatory and Cancer Diseases.
Couvineau A, Gomariz RP, Tan YV. Couvineau A, et al. Front Endocrinol (Lausanne). 2020 Sep 25;11:588157. doi: 10.3389/fendo.2020.588157. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33101216 Free PMC article. No abstract available.
Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice.
Zhu H, Aryal DK, Olsen RH, Urban DJ, Swearingen A, Forbes S, Roth BL, Hochgeschwender U. Zhu H, et al. Genesis. 2016 Aug;54(8):439-46. doi: 10.1002/dvg.22949. Epub 2016 Jun 3. Genesis. 2016. PMID: 27194399 Free PMC article.
DREADDs, designer receptors exclusively activated by designer drugs, are engineered G protein-coupled receptors (GPCR) which can precisely control GPCR signaling pathways (for example, Gq, Gs, and Gi). This chemogenetic technology for control of GPCR signalin …
DREADDs, designer receptors exclusively activated by designer drugs, are engineered G protein-coupled receptors (GPCR) which can prec …
GPCR Modulation in Breast Cancer.
Lappano R, Jacquot Y, Maggiolini M. Lappano R, et al. Int J Mol Sci. 2018 Dec 2;19(12):3840. doi: 10.3390/ijms19123840. Int J Mol Sci. 2018. PMID: 30513833 Free PMC article. Review.
Breast cancer is the most prevalent cancer found in women living in developed countries. Endocrine therapy is the mainstay of treatment for hormone-responsive breast tumors (about 70% of all breast cancers) and implies the use of selective estrogen receptor modulato …
Breast cancer is the most prevalent cancer found in women living in developed countries. Endocrine therapy is the mainstay of …
Chemokine/GPCR Signaling-Mediated EMT in Cancer Metastasis.
Tian X, Wang J, Jiang L, Jiang Y, Xu J, Feng X. Tian X, et al. J Oncol. 2022 Oct 11;2022:2208176. doi: 10.1155/2022/2208176. eCollection 2022. J Oncol. 2022. PMID: 36268282 Free PMC article. Review.
Metastasis, the chief cause of cancer-related deaths, is associated with epithelial-mesenchymal transition (EMT). In the tumor microenvironment, EMT can be triggered by chemokine/G-protein-coupled receptor (GPCR) signaling, which is closely associated with tumor pro …
Metastasis, the chief cause of cancer-related deaths, is associated with epithelial-mesenchymal transition (EMT). In the tumor microe …
The landscape of cancer-rewired GPCR signaling axes.
Arora C, Matic M, Bisceglia L, Di Chiaro P, De Oliveira Rosa N, Carli F, Clubb L, Nemati Fard LA, Kargas G, Diaferia GR, Vukotic R, Licata L, Wu G, Natoli G, Gutkind JS, Raimondi F. Arora C, et al. Cell Genom. 2024 May 8;4(5):100557. doi: 10.1016/j.xgen.2024.100557. Cell Genom. 2024. PMID: 38723607 Free PMC article.
We explored the dysregulation of G-protein-coupled receptor (GPCR) ligand systems in cancer transcriptomics datasets to uncover new therapeutics opportunities in oncology. ...The expression of both receptor-ligand (or enzymes) partners improved patient stratificatio …
We explored the dysregulation of G-protein-coupled receptor (GPCR) ligand systems in cancer transcriptomics datasets to uncove …
GRK5 is a regulator of fibroblast activation and cardiac fibrosis.
Eguchi A, Coleman R, Gresham K, Gao E, Ibetti J, Chuprun JK, Koch WJ. Eguchi A, et al. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2012854118. doi: 10.1073/pnas.2012854118. Proc Natl Acad Sci U S A. 2021. PMID: 33500351 Free PMC article.
Stress conditions, such as a myocardial infarction (MI), can activate quiescent fibroblasts into synthetic and contractile myofibroblasts. G protein-coupled receptor kinase 5 (GRK5) is an important mediator of cardiovascular homeostasis through dampening of GPCR sig …
Stress conditions, such as a myocardial infarction (MI), can activate quiescent fibroblasts into synthetic and contractile myofibroblasts. G …
Unintended Effects of GPCR-Targeted Drugs on the Cancer Phenotype.
Cornwell AC, Feigin ME. Cornwell AC, et al. Trends Pharmacol Sci. 2020 Dec;41(12):1006-1022. doi: 10.1016/j.tips.2020.10.001. Epub 2020 Oct 22. Trends Pharmacol Sci. 2020. PMID: 33198923 Free PMC article. Review.
Emerging evidence has implicated GPCRs as drivers of cancer progression, therapeutic resistance, and metastasis. Therefore, the effects of commonly prescribed GPCR-targeted drugs must be reevaluated in the context of cancer. Epidemiological and experimental e …
Emerging evidence has implicated GPCRs as drivers of cancer progression, therapeutic resistance, and metastasis. Therefore, the effec …
The landscape of cancer rewired GPCR signaling axes.
Arora C, Matic M, DiChiaro P, Rosa NO, Carli F, Clubb L, Fard LAN, Kargas G, Diaferia G, Vukotic R, Licata L, Wu G, Natoli G, Gutkind JS, Raimondi F. Arora C, et al. bioRxiv [Preprint]. 2023 Oct 11:2023.03.13.532291. doi: 10.1101/2023.03.13.532291. bioRxiv. 2023. Update in: Cell Genom. 2024 May 8;4(5):100557. doi: 10.1016/j.xgen.2024.100557. PMID: 37398064 Free PMC article. Updated. Preprint.
We explored the dysregulation of GPCR ligand signaling systems in cancer transcriptomics datasets to uncover new therapeutics opportunities in oncology. ...We found that several GPCRs signaling components were significantly associated with patient survival in a c …
We explored the dysregulation of GPCR ligand signaling systems in cancer transcriptomics datasets to uncover new therapeutics …
3,170,781 results
You have reached the last available page of results. Please see the User Guide for more information.