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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1990 1
1997 1
1998 26
1999 82
2000 141
2001 113
2002 191
2003 162
2004 185
2005 160
2006 176
2007 177
2008 185
2009 174
2010 119
2011 104
2012 116
2013 92
2014 87
2015 73
2016 61
2017 62
2018 38
2019 15
2020 0
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Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex
Poulopoulos A, et al. Nature 2019. PMID 30626971 Free PMC article.
Each projection is formed by growth cones-subcellular specializations at the tips of growing axons, encompassing sets of molecules that control projection-specific growth, guidance, and target selection(1). To investigate the set of molecules within native growth cones that form specific connections, here we developed growth cone sorting and subcellular RNA-proteome mapping, an approach that identifies and quantifies local transcriptomes and proteomes from labelled growth cones of single projections in vivo. ...
Each projection is formed by growth cones-subcellular specializations at the tips of growing axons, encompassing sets of molec …
The Microtubule-Associated Protein Tau Mediates the Organization of Microtubules and Their Dynamic Exploration of Actin-Rich Lamellipodia and Filopodia of Cortical Growth Cones.
Biswas S and Kalil K. J Neurosci 2018. PMID 29167405 Free PMC article.
These results suggest an important role for tau in regulating cytoskeletal organization and dynamics during growth cone behaviors.SIGNIFICANCE STATEMENT Growth cones are the motile tips of growing axons whose guidance behaviors require interaction of the dynamic actin and microtubule cytoskeleton. ...Here, using super resolution microscopy, live-cell imaging, and tau knockdown, we show for the first time in living axonal growth cones that tau is important for microtubule bundling and microtubule exploration of the actin-rich growth cone periphery. ...
These results suggest an important role for tau in regulating cytoskeletal organization and dynamics during growth cone behaviors.SIG …
Microtubules and Growth Cones: Motors Drive the Turn.
Kahn OI and Baas PW. Trends Neurosci 2016 - Review. PMID 27233682 Free PMC article.
Navigation of the growth cone at the tip of the developing axon is crucial for the proper wiring of the nervous system. Mechanisms of actin-dependent growth cone steering, via signaling cascades, are well documented. Microtubules are also important in growth cone guidance, because their polarized invasion into the peripheral domain on one side of the growth cone is essential for it to turn in that direction. ...
Navigation of the growth cone at the tip of the developing axon is crucial for the proper wiring of the nervous system. Mechanisms of …
Actin-based growth cone motility and guidance.
Omotade OF, et al. Mol Cell Neurosci 2017 - Review. PMID 28268126 Free PMC article.
Nerve growth cones, the dilated tip of developing axons, are equipped with exquisite abilities to sense environmental cues and to move rapidly through complex terrains of developing brain, leading the axons to their specific targets for precise neuronal wiring. The actin cytoskeleton is the major component of the growth cone that powers its directional motility. Past research has provided significant insights into the mechanisms by which growth cones translate extracellular signals into directional migration. ...
Nerve growth cones, the dilated tip of developing axons, are equipped with exquisite abilities to sense environmental cues and …
Understanding axon guidance: are we nearly there yet?
Stoeckli ET. Development 2018 - Review. PMID 29759980 Free article.
Recent studies have demonstrated how crosstalk between different families of guidance receptors can regulate axonal navigation at choice points, and how changes in growth cone behaviour at intermediate targets require changes in the surface expression of receptors. ...
Recent studies have demonstrated how crosstalk between different families of guidance receptors can regulate axonal navigation at choice poi …
Determinants of Axon Growth, Plasticity, and Regeneration in the Context of Spinal Cord Injury.
Filous AR and Schwab JM. Am J Pathol 2018 - Review. PMID 29030051 Free article.
Herein, we survey mechanisms leading to the formation of dystrophic growth cone at the injured axonal tip, the subsequent axonal dieback, and the molecular determinants of axon growth, plasticity, and regeneration in the context of spinal cord injury....
Herein, we survey mechanisms leading to the formation of dystrophic growth cone at the injured axonal tip, the subsequent axonal dieb …
Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones.
Vysokov NV, et al. Elife 2018. PMID 30457553 Free PMC article.
We found that released Lasso binds to cell-surface latrophilin-1 on axonal growth cones. Using microfluidic devices to create stable gradients of soluble Lasso, we show that it induces axonal attraction, without increasing neurite outgrowth. ...After binding latrophilin-1, Lasso causes downstream signaling, which leads to an increase in cytosolic calcium and enhanced exocytosis, processes that are known to mediate growth cone steering. ...
We found that released Lasso binds to cell-surface latrophilin-1 on axonal growth cones. Using microfluidic devices to create …
Vesicular movements in the growth cone.
Nozumi M and Igarashi M. Neurochem Int 2018 - Review. PMID 28962923
Growth cones, which are the highly motile tips of extending neuronal processes in developing neurons, have many vesicles. These vesicles are likely essential for the membrane expansion that is required for nerve growth, and probably coordinate with rearrangement of the cytoskeletons. ...Vesicles mainly accumulate in the central domain of growth cones. However, the dynamics of vesicles in each domain, for example, clathrin dependency, are totally distinct from each other. ...
Growth cones, which are the highly motile tips of extending neuronal processes in developing neurons, have many vesicles. Thes
An introduction to TRP channels
Ramsey IS, et al. Annu Rev Physiol 2006 - Review. PMID 16460286
Our review of recent literature implicating TRP channels in neuronal growth cone steering suggests that TRPs may function more widely in cellular guidance and chemotaxis. ...
Our review of recent literature implicating TRP channels in neuronal growth cone steering suggests that TRPs may function more widely …
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