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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1998 1
1999 2
2001 7
2002 5
2003 3
2004 6
2005 14
2006 12
2007 18
2008 21
2009 15
2010 23
2011 33
2012 37
2013 53
2014 24
2015 24
2016 24
2017 18
2018 10
2019 2
2020 0
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Page 1
A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality.
Daigle TL, et al. Cell 2018. PMID 30007418 Free PMC article.
Here, we report a large set of driver and reporter transgenic mouse lines, including 23 new driver lines targeting a variety of cortical and subcortical cell populations and 26 new reporter lines expressing an array of molecular tools. ...These novel transgenic lines greatly expand the repertoire of high-precision genetic tools available to effectively identify, monitor, and manipulate distinct cell types in the mouse brain....
Here, we report a large set of driver and reporter transgenic mouse lines, including 23 new driver lines targeting a variety of corti …
Gene targeting in mice: a review
Bouabe H and Okkenhaug K. Methods Mol Biol 2013 - Review. PMID 23996268 Free PMC article.
., genes) of interest into the germline genome has rendered the mouse a powerful and indispensable experimental model in fundamental and medical research. ...Furthermore, the use of recombination systems, such as Cre/loxP or FRT/FLP, enables conditional induction or suppression of gene expression of interest in a restricted period of mouse's lifetime, in a particular cell type, or in a specific tissue. ...
., genes) of interest into the germline genome has rendered the mouse a powerful and indispensable experimental model in fundamental …
Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent.
Strathdee D, et al. PLoS One 2006. PMID 17183668 Free PMC article.
METHODOLOGY: In order to develop a reliable system for reproducibly expressing transgenes it was decided to insert constructs at the Gt(ROSA)26Sor locus. ...
METHODOLOGY: In order to develop a reliable system for reproducibly expressing transgenes it was decided to insert constructs at the Gt
Cre transgenic mouse lines.
Wang X. Methods Mol Biol 2009. PMID 19504077
The generation of conditional knockout mice is a multiple-step process, which involves mating the flox mutant mouse line (essential exon/s of the gene of interest are flanked by two LoxP sites) and the Cre-expressing mouse line. ...In addition, information regarding established Cre-expressing mouse lines will be provided....
The generation of conditional knockout mice is a multiple-step process, which involves mating the flox mutant mouse line (essential e …
Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes
Chu VT, et al. BMC Biotechnol 2016. PMID 26772810 Free PMC article.
BACKGROUND: The CRISPR/Cas9 system is increasingly used for gene inactivation in mouse zygotes, but homology-directed mutagenesis and use of inbred embryos are less established. ...Using this approach, we established a new mouse line for the Cre/loxP-dependent expression of Cas9. CONCLUSIONS: Altogether, our protocols and resources support the fast and direct generation of new Rosa26 knock-in alleles and of Cas9-mediated in vivo gene editing in the widely used C57BL/6 inbred strain....
BACKGROUND: The CRISPR/Cas9 system is increasingly used for gene inactivation in mouse zygotes, but homology-directed mutagenesis and …
Gene editing in mouse zygotes using the CRISPR/Cas9 system.
Wefers B, et al. Methods 2017. PMID 28263886
The generation of targeted mouse mutants is a key technology for biomedical research. Using the CRISPR/Cas9 system for induction of targeted double-strand breaks, gene editing can be performed in a single step directly in mouse zygotes. ...
The generation of targeted mouse mutants is a key technology for biomedical research. Using the CRISPR/Cas9 system for induction of t …
Regional astrocyte allocation regulates CNS synaptogenesis and repair
Tsai HH, et al. Science 2012. PMID 22745251 Free PMC article.
We show that astrocytes are allocated to spatial domains in mouse spinal cord and brain in accordance with their embryonic sites of origin in the ventricular zone. ...
We show that astrocytes are allocated to spatial domains in mouse spinal cord and brain in accordance with their embryonic sites of o …
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
Madisen L, et al. Nat Neurosci 2012. PMID 22446880 Free PMC article.
Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 and archaerhodopsin Arch-ER2. ...
Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTo …
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