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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 14
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1488
1843 1118
1844 1248
1845 1277
1846 1406
1847 1367
1848 1203
1849 1207
1850 1126
1851 1229
1852 1310
1853 1558
1854 1306
1855 1586
1856 1587
1857 1488
1858 1542
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1138
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1809
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2179
1878 2454
1879 2399
1880 2646
1881 3149
1882 2742
1883 3126
1884 3049
1885 3337
1886 3291
1887 3965
1888 4002
1889 4194
1890 4024
1891 3607
1892 4080
1893 4370
1894 3801
1895 4129
1896 4412
1897 4689
1898 4631
1899 4169
1900 3785
1901 3886
1902 3967
1903 3910
1904 4059
1905 4067
1906 3872
1907 4323
1908 4459
1909 4687
1910 4799
1911 5006
1912 4906
1913 5105
1914 5135
1915 4640
1916 4543
1917 4281
1918 4567
1919 4619
1920 4960
1921 4628
1922 4123
1923 4432
1924 4851
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5496
1932 5548
1933 5610
1934 5508
1935 5661
1936 5384
1937 5308
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4517
1944 4745
1945 20421
1946 53739
1947 64968
1948 70729
1949 62805
1950 85750
1951 103810
1952 108147
1953 108914
1954 105913
1955 108541
1956 107005
1957 111515
1958 109458
1959 109989
1960 112211
1961 120167
1962 125670
1963 141520
1964 162087
1965 176641
1966 179756
1967 191504
1968 207845
1969 215073
1970 218978
1971 222890
1972 227526
1973 230635
1974 234516
1975 248229
1976 250253
1977 249652
1978 257922
1979 265172
1980 266940
1981 271246
1982 282817
1983 294425
1984 302313
1985 318510
1986 330956
1987 346888
1988 363208
1989 377210
1990 382443
1991 380398
1992 382012
1993 390259
1994 401270
1995 410482
1996 420367
1997 418093
1998 435470
1999 452668
2000 489613
2001 502049
2002 520006
2003 547479
2004 591091
2005 648870
2006 694227
2007 731967
2008 779346
2009 818945
2010 881931
2011 958342
2012 1024172
2013 1075452
2014 1129911
2015 1172970
2016 1207506
2017 1231026
2018 1274820
2019 1336098
2020 1533682
2021 1678629
2022 1679905
2023 1592815
2024 1632388
2025 405366

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36,283,198 results

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Quoted phrases not found in phrase index: "Bacterial Proteins Chemistry Genetics Metabolism", "Zinc Chemistry Metabolism"
Page 1
Bacterial glycoproteomics.
Hitchen PG, Dell A. Hitchen PG, et al. Microbiology (Reading). 2006 Jun;152(Pt 6):1575-1580. doi: 10.1099/mic.0.28859-0. Microbiology (Reading). 2006. PMID: 16735721 Free article. Review.
Glycosylated proteins are ubiquitous components of eukaryote cellular surfaces, where the glycan moieties are implicated in a wide range of cell-cell recognition events. ...This review highlights the capabilities of high-sensitivity mass spectrometry for carbohydrate struc …
Glycosylated proteins are ubiquitous components of eukaryote cellular surfaces, where the glycan moieties are implicated in a wide ra …
The mismetallation of enzymes during oxidative stress.
Imlay JA. Imlay JA. J Biol Chem. 2014 Oct 10;289(41):28121-8. doi: 10.1074/jbc.R114.588814. Epub 2014 Aug 26. J Biol Chem. 2014. PMID: 25160623 Free PMC article. Review.
This system is disrupted, however, by superoxide and hydrogen peroxide. These species oxidize ferrous iron and thereby displace it from many iron-dependent mononuclear enzymes. Ultimately, zinc binds in its place, confers little activity, and imposes metabolic …
This system is disrupted, however, by superoxide and hydrogen peroxide. These species oxidize ferrous iron and thereby displace it fr …
Exceptionally versatile - arginine in bacterial post-translational protein modifications.
Lassak J, Koller F, Krafczyk R, Volkwein W. Lassak J, et al. Biol Chem. 2019 Oct 25;400(11):1397-1427. doi: 10.1515/hsz-2019-0182. Biol Chem. 2019. PMID: 31188742 Free article. Review.
Post-translational modifications (PTM) are the evolutionary solution to challenge and extend the boundaries of genetically predetermined proteomic diversity. As PTMs are highly dynamic, they also hold an enormous regulatory potential. ...
Post-translational modifications (PTM) are the evolutionary solution to challenge and extend the boundaries of genetically predetermi …
Zinc-handling in cyanobacteria: an update.
Blindauer CA. Blindauer CA. Chem Biodivers. 2008 Oct;5(10):1990-2013. doi: 10.1002/cbdv.200890183. Chem Biodivers. 2008. PMID: 18972521 Review.
Zinc is a constituent of all six classes of enzymes, plays important roles in gene regulation, and is thought to be essential for most organisms. Despite initial discoveries of cyanobacterial metallothioneins, zinc efflux pumps and uptake systems, and zinc se …
Zinc is a constituent of all six classes of enzymes, plays important roles in gene regulation, and is thought to be essential for mos …
Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9.
Gupta RM, Musunuru K. Gupta RM, et al. J Clin Invest. 2014 Oct;124(10):4154-61. doi: 10.1172/JCI72992. Epub 2014 Oct 1. J Clin Invest. 2014. PMID: 25271723 Free PMC article. Review.
The opportunity now exists for investigators to manipulate virtually any gene in a diverse range of cell types and organisms with targeted nucleases designed with sequence-specific DNA-binding domains. The rapid development of the field has allowed for highly effici …
The opportunity now exists for investigators to manipulate virtually any gene in a diverse range of cell types and organisms with targeted n …
Structure and Function of Cu(I)- and Zn(II)-ATPases.
Sitsel O, Grønberg C, Autzen HE, Wang K, Meloni G, Nissen P, Gourdon P. Sitsel O, et al. Biochemistry. 2015 Sep 22;54(37):5673-83. doi: 10.1021/acs.biochem.5b00512. Epub 2015 Sep 10. Biochemistry. 2015. PMID: 26132333 Review.
Copper and zinc are micronutrients essential for the function of many enzymes while also being toxic at elevated concentrations. ...Recent biochemical studies and crystal structures have significantly improved our understanding of the transport mechanisms of these prote …
Copper and zinc are micronutrients essential for the function of many enzymes while also being toxic at elevated concentrations. ...R …
Bacterial RNA polymerases: the wholo story.
Murakami KS, Darst SA. Murakami KS, et al. Curr Opin Struct Biol. 2003 Feb;13(1):31-9. doi: 10.1016/s0959-440x(02)00005-2. Curr Opin Struct Biol. 2003. PMID: 12581657 Review.
Recent structural and biophysical results have provided unprecedented insights into the structure and function of the bacterial RNA polymerase holoenzyme as it goes through the steps of transcription initiation. ...
Recent structural and biophysical results have provided unprecedented insights into the structure and function of the bacterial RNA p …
The Catabolic Network of Aromatoleum aromaticum EbN1T.
Becker P, Wünsch D, Wöhlbrand L, Neumann-Schaal M, Schomburg D, Rabus R. Becker P, et al. Microb Physiol. 2024;34(1):1-77. doi: 10.1159/000534425. Epub 2023 Oct 10. Microb Physiol. 2024. PMID: 37816339 Free article. Review.
The constructed catabolic network is comprised of 256 genes, which occupy 7.5% of the coding regions of the genome. In total, 219 encoded proteins have been identified by differential proteomics, yielding a proteome coverage of 74% of the network. ...
The constructed catabolic network is comprised of 256 genes, which occupy 7.5% of the coding regions of the genome. In total, 219 encoded …
Beta-lactamases and bacterial resistance to antibiotics.
Frère JM. Frère JM. Mol Microbiol. 1995 May;16(3):385-95. doi: 10.1111/j.1365-2958.1995.tb02404.x. Mol Microbiol. 1995. PMID: 7565100 Review.
The efficiency of beta-lactam antibiotics, which are among our most useful chemotherapeutic weapons, is continuously challenged by the emergence of resistant bacterial strains. This is most often due to the production of beta-lactamases by the resistant cells. ...The eluci …
The efficiency of beta-lactam antibiotics, which are among our most useful chemotherapeutic weapons, is continuously challenged by the emerg …
diDO-IPTL: A Peptide-Labeling Strategy for Precision Quantitative Proteomics.
Waldbauer J, Zhang L, Rizzo A, Muratore D. Waldbauer J, et al. Anal Chem. 2017 Nov 7;89(21):11498-11504. doi: 10.1021/acs.analchem.7b02752. Epub 2017 Oct 23. Anal Chem. 2017. PMID: 29016104
The diDO-IPTL approach combines two advances in isobaric peptide terminal labeling (IPTL) methodology: first, a one-pot chemical labeling strategy for attaching isotopic tags to both the N- and C-termini of tryptic peptides, and second, a search engine (based on the Morpheus algo …
The diDO-IPTL approach combines two advances in isobaric peptide terminal labeling (IPTL) methodology: first, a one-pot chemical labeling st …
36,283,198 results
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