"HIV Reverse Transcriptase"[nm] - Search Results

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Subject: "HIV Reverse Transcriptase"[nm] - PubMed

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Spectrum of Non-Nucleoside Reverse Transcriptase Inhibitor-Associated Drug Resistance Mutations in Persons Living with HIV-1 Receiving Rilpivirine.

Nagarajan P, Zhou J, Di Teodoro G, Incardona F, Seguin-Devaux C, Kaiser R, Abecasis AB, Gomes P, Tao K, Zazzi M, Shafer RW; EuResist Network. Nagarajan P, et al. Viruses. 2024 Oct 31;16(11):1715. doi: 10.3390/v16111715. Viruses. 2024. PMID: 39599830 Free PMC article.

Discovery of novel fused-heterocycle-bearing diarypyrimidine derivatives as HIV-1 potent NNRTIs targeting tolerant region I for enhanced antiviral activity and resistance profile.

Dai J, Jiang X, Gao H, Huang B, De Clercq E, Pannecouque C, Du S, Liu X, Zhan P. Dai J, et al. Eur J Med Chem. 2025 Jan 5;281:117033. doi: 10.1016/j.ejmech.2024.117033. Epub 2024 Nov 7. Eur J Med Chem. 2025. PMID: 39536498

Expanding the Solvent/Protein Region Occupation of the Non-Nucleoside Reverse Transcriptase Inhibitor Binding Pocket for Improved Broad-Spectrum Anti-HIV-1 Efficacy: from Rigid Phenyl-Diarylpyrimidines to Flexible Hydrophilic Piperidine-Diarylpyrimidines.

Huang WJ, Pannecouque C, De Clercq E, Corona A, Maloccu S, Tramontano E, Wang S, Chen FE. Huang WJ, et al. J Med Chem. 2024 Nov 14;67(21):19889-19904. doi: 10.1021/acs.jmedchem.4c02413. Epub 2024 Nov 5. J Med Chem. 2024. PMID: 39498544

REverse transcriptase ACTivity (REACT) assay for point-of-care measurement of established and emerging antiretrovirals for HIV treatment and prevention.

Brainerd C, Singh MA, Tatka J, Craig C, Gilligan-Steinberg S, Panpradist N, Chang MM, Lutz B, Olanrewaju AO. Brainerd C, et al. Anal Bioanal Chem. 2024 Dec;416(29):6809-6818. doi: 10.1007/s00216-024-05602-4. Epub 2024 Oct 28. Anal Bioanal Chem. 2024. PMID: 39466376

Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors (2019-2023).

Nie MZ, Zhang SS, Gu SX, Long J, Zhu YY. Nie MZ, et al. Eur J Med Chem. 2024 Dec 15;280:116973. doi: 10.1016/j.ejmech.2024.116973. Epub 2024 Oct 18. Eur J Med Chem. 2024. PMID: 39432934 Review.

HIV-1 Reverse Transcriptase Error Rates and Transcriptional Thresholds Based on Single-strand Consensus Sequencing of Target RNA Derived From In Vitro-transcription and HIV-infected Cells.

Martínez Del Río J, Frutos-Beltrán E, Sebastián-Martín A, Lasala F, Yasukawa K, Delgado R, Menéndez-Arias L. Martínez Del Río J, et al. J Mol Biol. 2024 Nov 15;436(22):168815. doi: 10.1016/j.jmb.2024.168815. Epub 2024 Oct 9. J Mol Biol. 2024. PMID: 39384034 Free article.

Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses.

Jiang X, Zalloum WA, Gao Z, Dai J, Ji X, Xie M, Dong G, De Clercq E, Huang B, Pannecouque C, Zhan P, Liu X. Jiang X, et al. Eur J Med Chem. 2024 Dec 15;280:116941. doi: 10.1016/j.ejmech.2024.116941. Epub 2024 Oct 5. Eur J Med Chem. 2024. PMID: 39369484

Fragment Addition-Based Design of Heteroaromatic-Biphenyl-DAPYs as Potent and Orally Available Non-nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Enhanced Safety.

Huang WJ, Pannecouque C, De Clercq E, Wang S, Chen FE. Huang WJ, et al. J Med Chem. 2024 Oct 10;67(19):17568-17584. doi: 10.1021/acs.jmedchem.4c01571. Epub 2024 Oct 1. J Med Chem. 2024. PMID: 39352547

Treatment Management Challenges in Naïve and Experienced HIV-1-Infected Individuals Carrying the M184V Mutation.

Mimtsoudis I, Tsachouridou O, Akinosoglou K, Metallidis S. Mimtsoudis I, et al. Viruses. 2024 Aug 30;16(9):1392. doi: 10.3390/v16091392. Viruses. 2024. PMID: 39339868 Free PMC article. Review.

A Step Towards Optimization of Amide-Linked Coumarin Pharmacophore: As an Anti-HIV Agent.

Joshi HC, Kumar V, Purohit P, Pandey IP, Joshi G. Joshi HC, et al. Curr HIV Res. 2024;22(5):279-289. doi: 10.2174/011570162X308550240821074309. Curr HIV Res. 2024. PMID: 39317999

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