"HIV Reverse Transcriptase/antagonists and inhibitors"[MeSH] - Search Results

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Year	Number of Results
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1,862 results

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Discovery of novel fused-heterocycle-bearing diarypyrimidine derivatives as HIV-1 potent NNRTIs targeting tolerant region I for enhanced antiviral activity and resistance profile.

Dai J, Jiang X, Gao H, Huang B, De Clercq E, Pannecouque C, Du S, Liu X, Zhan P. Dai J, et al. Eur J Med Chem. 2025 Jan 5;281:117033. doi: 10.1016/j.ejmech.2024.117033. Epub 2024 Nov 7. Eur J Med Chem. 2025. PMID: 39536498

Expanding the Solvent/Protein Region Occupation of the Non-Nucleoside Reverse Transcriptase Inhibitor Binding Pocket for Improved Broad-Spectrum Anti-HIV-1 Efficacy: from Rigid Phenyl-Diarylpyrimidines to Flexible Hydrophilic Piperidine-Diarylpyrimidines.

Huang WJ, Pannecouque C, De Clercq E, Corona A, Maloccu S, Tramontano E, Wang S, Chen FE. Huang WJ, et al. J Med Chem. 2024 Nov 14;67(21):19889-19904. doi: 10.1021/acs.jmedchem.4c02413. Epub 2024 Nov 5. J Med Chem. 2024. PMID: 39498544

REverse transcriptase ACTivity (REACT) assay for point-of-care measurement of established and emerging antiretrovirals for HIV treatment and prevention.

Brainerd C, Singh MA, Tatka J, Craig C, Gilligan-Steinberg S, Panpradist N, Chang MM, Lutz B, Olanrewaju AO. Brainerd C, et al. Anal Bioanal Chem. 2024 Dec;416(29):6809-6818. doi: 10.1007/s00216-024-05602-4. Epub 2024 Oct 28. Anal Bioanal Chem. 2024. PMID: 39466376

Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors (2019-2023).

Nie MZ, Zhang SS, Gu SX, Long J, Zhu YY. Nie MZ, et al. Eur J Med Chem. 2024 Dec 15;280:116973. doi: 10.1016/j.ejmech.2024.116973. Epub 2024 Oct 18. Eur J Med Chem. 2024. PMID: 39432934 Review.

Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses.

Jiang X, Zalloum WA, Gao Z, Dai J, Ji X, Xie M, Dong G, De Clercq E, Huang B, Pannecouque C, Zhan P, Liu X. Jiang X, et al. Eur J Med Chem. 2024 Dec 15;280:116941. doi: 10.1016/j.ejmech.2024.116941. Epub 2024 Oct 5. Eur J Med Chem. 2024. PMID: 39369484

Fragment Addition-Based Design of Heteroaromatic-Biphenyl-DAPYs as Potent and Orally Available Non-nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Enhanced Safety.

Huang WJ, Pannecouque C, De Clercq E, Wang S, Chen FE. Huang WJ, et al. J Med Chem. 2024 Oct 10;67(19):17568-17584. doi: 10.1021/acs.jmedchem.4c01571. Epub 2024 Oct 1. J Med Chem. 2024. PMID: 39352547

A Step Towards Optimization of Amide-Linked Coumarin Pharmacophore: As an Anti-HIV Agent.

Joshi HC, Kumar V, Purohit P, Pandey IP, Joshi G. Joshi HC, et al. Curr HIV Res. 2024;22(5):279-289. doi: 10.2174/011570162X308550240821074309. Curr HIV Res. 2024. PMID: 39317999

Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation.

Zhuo Z, Wang Z, Jing L, Zhang T, Ge A, Zhou Z, Liu Y, Li X, De Clercq E, Pannecouque C, Zhan P, Liu X, Kang D. Zhuo Z, et al. Int J Mol Sci. 2024 Aug 20;25(16):9028. doi: 10.3390/ijms25169028. Int J Mol Sci. 2024. PMID: 39201714 Free PMC article.

Discovery of potent HIV-1 NNRTIs by CuAAC click-chemistry-based miniaturized synthesis, rapid screening and structure optimization.

Jing L, Wu G, Zhao F, Jiang X, Liu N, Feng D, Sun Y, Zhang T, De Clercq E, Pannecouque C, Kang D, Liu X, Zhan P. Jing L, et al. Eur J Med Chem. 2024 Nov 5;277:116772. doi: 10.1016/j.ejmech.2024.116772. Epub 2024 Aug 20. Eur J Med Chem. 2024. PMID: 39167895

Discovery of 2,4,6-trisubstituted pyrimidine derivatives as novel potent HIV-1 NNRTIs by exploiting the tolerant region II of the NNIBP.

Zhou Z, Sun Y, Qin Y, Wang N, Zhao F, Wang Z, Clercq E, Pannecouque C, Zhan P, Kang D, Liu X. Zhou Z, et al. Eur J Med Chem. 2024 Nov 5;277:116708. doi: 10.1016/j.ejmech.2024.116708. Epub 2024 Jul 27. Eur J Med Chem. 2024. PMID: 39094273

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