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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 8
1997 4
1998 9
1999 9
2000 10
2001 10
2002 11
2003 8
2004 4
2005 12
2006 9
2007 11
2008 15
2009 21
2010 12
2011 15
2012 16
2013 22
2014 33
2015 21
2016 21
2017 35
2018 16
2019 3
2020 0
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300 results
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Page 1
Ketamine blocks bursting in the lateral habenula to rapidly relieve depression.
Yang Y, et al. Nature 2018. PMID 29446381
Here we show that blockade of NMDAR-dependent bursting activity in the 'anti-reward center', the lateral habenula (LHb), mediates the rapid antidepressant actions of ketamine in rat and mouse models of depression. ...
Here we show that blockade of NMDAR-dependent bursting activity in the 'anti-reward center', the lateral habenula (LHb), mediates the …
Lateral habenula in the pathophysiology of depression.
Yang Y, et al. Curr Opin Neurobiol 2018 - Review. PMID 29175713 Free article.
Recently, the lateral habenula (LHb) has emerged as a key brain region in the pathophysiology of depression. Increasing evidence from rodent, non-human primate and human studies indicates that the aberrant activity of the LHb is associated with depressive symptoms such as helplessness, anhedonia, and excessive negative focus. ...
Recently, the lateral habenula (LHb) has emerged as a key brain region in the pathophysiology of depression. Increasing evidence from …
Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq
Pandey S, et al. Curr Biol 2018. PMID 29576475 Free PMC article.
We combined single-cell RNA-seq (scRNA-seq) with anatomical brain registration to create a comprehensive map of the zebrafish habenula, a conserved forebrain hub involved in pain processing and learning. ...Strikingly, despite brain growth and functional maturation, cell types were retained between the larval and adult habenula. This study provides a gene expression atlas to dissect habenular development and function and offers a general framework for the comprehensive characterization of other brain regions....
We combined single-cell RNA-seq (scRNA-seq) with anatomical brain registration to create a comprehensive map of the zebrafish habenula
Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression.
Cui Y, et al. Nature 2018. PMID 29446379
Enhanced bursting activity of neurons in the lateral habenula (LHb) is essential in driving depression-like behaviours, but the cause of this increase has been unknown. ...
Enhanced bursting activity of neurons in the lateral habenula (LHb) is essential in driving depression-like behaviours, but the cause …
The lateral habenula and the serotonergic system.
Metzger M, et al. Pharmacol Biochem Behav 2017 - Review. PMID 28528079
The habenula (Hb) is an epithalamic structure differentiated into two nuclear complexes, medial (MHb) and lateral habenula (LHb). ...
The habenula (Hb) is an epithalamic structure differentiated into two nuclear complexes, medial (MHb) and lateral habenula (LH …
The habenula.
Namboodiri VM, et al. Curr Biol 2016. PMID 27728786 Free article.
The habenula is a tiny brain region the size of a pea in humans. This region is highly conserved across vertebrates and has been traditionally overlooked by neuroscientists. ...In this Primer, we will discuss the recent and converging evidence that points to the habenula as a key brain region for motivation and decision-making....
The habenula is a tiny brain region the size of a pea in humans. This region is highly conserved across vertebrates and has been trad …
Input-specific control of reward and aversion in the ventral tegmental area
Lammel S, et al. Nature 2012. PMID 23064228 Free PMC article.
Here we show that, because of differences in synaptic connectivity, activation of inputs to the VTA from the laterodorsal tegmentum and the lateral habenula elicit reward and aversion in mice, respectively. Laterodorsal tegmentum neurons preferentially synapse on dopamine neurons projecting to the nucleus accumbens lateral shell, whereas lateral habenula neurons synapse primarily on dopamine neurons projecting to the medial prefrontal cortex as well as on GABAergic (γ-aminobutyric-acid-containing) neurons in the rostromedial tegmental nucleus. ...
Here we show that, because of differences in synaptic connectivity, activation of inputs to the VTA from the laterodorsal tegmentum and the …
A basal ganglia circuit for evaluating action outcomes
Stephenson-Jones M, et al. Nature 2016. PMID 27652894 Free PMC article.
Here we show that neurons in the habenula-projecting globus pallidus (GPh) in mice are essential for evaluating action outcomes and are regulated by a specific set of inputs from the basal ganglia. ...
Here we show that neurons in the habenula-projecting globus pallidus (GPh) in mice are essential for evaluating action outcomes and a …
Afferent and efferent connections of the interpeduncular nucleus with special reference to circuits involving the habenula and raphe nuclei.
Lima LB, et al. J Comp Neurol 2017. PMID 28340505
The habenula is an epithalamic structure differentiated into two nuclear complexes, medial (MHb) and lateral habenula (LHb). ...
The habenula is an epithalamic structure differentiated into two nuclear complexes, medial (MHb) and lateral habenula (LHb). . …
Microarray analysis of transcripts with elevated expressions in the rat medial or lateral habenula suggest fast GABAergic excitation in the medial habenula and habenular involvement in the regulation of feeding and energy balance.
Wagner F, et al. Brain Struct Funct 2016. PMID 26888156
In vertebrates the "anti-reward-system" mainly is represented by the habenula and its medial (MHb) and especially lateral (LHb) complexes. ...Quite surprisingly, our data indicate potentially inhibitory effects of acetylcholine and glutamate in the habenula. In addition, the absence of the K-Cl co-transporter 2 supports a largely excitatory role of GABAergic transmission especially in the MHb. ...
In vertebrates the "anti-reward-system" mainly is represented by the habenula and its medial (MHb) and especially lateral (LHb) compl …
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