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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1872 2
1873 2
1878 1
1882 1
1884 1
1886 1
1890 1
1891 1
1893 1
1896 1
1897 1
1898 1
1900 2
1901 1
1902 2
1904 1
1905 1
1907 2
1910 1
1912 1
1914 1
1918 4
1921 1
1923 1
1929 2
1930 2
1933 2
1937 2
1938 1
1946 3
1947 3
1948 3
1949 5
1950 4
1951 11
1952 8
1953 9
1954 6
1955 10
1956 8
1957 18
1958 6
1959 8
1960 13
1961 11
1962 20
1963 5
1964 15
1965 29
1966 14
1967 28
1968 20
1969 16
1970 24
1971 23
1972 32
1973 43
1974 36
1975 55
1976 49
1977 53
1978 48
1979 54
1980 45
1981 53
1982 57
1983 62
1984 56
1985 81
1986 60
1987 57
1988 72
1989 74
1990 112
1991 82
1992 87
1993 100
1994 101
1995 203
1996 156
1997 180
1998 274
1999 246
2000 223
2001 208
2002 254
2003 250
2004 270
2005 211
2006 271
2007 359
2008 499
2009 434
2010 448
2011 520
2012 580
2013 542
2014 596
2015 570
2016 592
2017 535
2018 567
2019 561
2020 630
2021 655
2022 580
2023 536
2024 506
2025 237

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12,815 results

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Page 1
The history of haemophilia - a short review.
Schramm W. Schramm W. Thromb Res. 2014 Nov;134 Suppl 1:S4-9. doi: 10.1016/j.thromres.2013.10.020. Epub 2014 Feb 7. Thromb Res. 2014. PMID: 24513149 Review.
A turning point in the history of haemophilia came in the middle of the 20th century when researchers identified an "antihaemophilic globulin" that could reduce the clotting time in haemophilic blood, thereby paving the way for the introduction of cryoprecipitate and the f …
A turning point in the history of haemophilia came in the middle of the 20th century when researchers identified an "antihaemophilic …
Advances in the management of haemophilia: emerging treatments and their mechanisms.
Okaygoun D, Oliveira DD, Soman S, Williams R. Okaygoun D, et al. J Biomed Sci. 2021 Sep 14;28(1):64. doi: 10.1186/s12929-021-00760-4. J Biomed Sci. 2021. PMID: 34521404 Free PMC article. Review.
Several novel pharmacological therapies developed for haemophilia aim to rebalance the clotting cascade and potentially circumvent the aforementioned challenges. ...These therapies carry the potential of revolutionising haemophilia treatment by alleviating the curre …
Several novel pharmacological therapies developed for haemophilia aim to rebalance the clotting cascade and potentially circumvent th …
Haemophilia: factoring in new therapies.
Fassel H, McGuinn C. Fassel H, et al. Br J Haematol. 2021 Sep;194(5):835-850. doi: 10.1111/bjh.17580. Epub 2021 Jul 28. Br J Haematol. 2021. PMID: 34322873 Review.
Haemophilia is an inherited bleeding disorder in which the haemostatic defect results from deficiency of coagulation factor VIII (FVIII) in haemophilia A or factor IX (FIX) in haemophilia B. ...In the present review, we will discuss currently available treatm …
Haemophilia is an inherited bleeding disorder in which the haemostatic defect results from deficiency of coagulation factor VIII (FVI …
Targeting higher factor VIII levels for prophylaxis in haemophilia A: a narrative review.
Malec L, Matino D. Malec L, et al. Haemophilia. 2023 Nov;29(6):1419-1429. doi: 10.1111/hae.14866. Epub 2023 Sep 27. Haemophilia. 2023. PMID: 37758651 Review.
INTRODUCTION: The standard of care in severe haemophilia A is prophylaxis, which has historically aimed for a factor VIII (FVIII) trough level of 1%. ...AIM: The aim of this review was to evaluate evidence supporting the relationship between targeting higher FVIII activity …
INTRODUCTION: The standard of care in severe haemophilia A is prophylaxis, which has historically aimed for a factor VIII (FVIII) tro …
[Haemophilia].
Loomans JI, Lock J, Peters M, Leebeek FW, Cnossen MH, Fijnvandraat K. Loomans JI, et al. Ned Tijdschr Geneeskd. 2014;158:A7357. Ned Tijdschr Geneeskd. 2014. PMID: 25351381 Review. Dutch.
A deficiency of clotting factor VIII (FVIII; haemophilia A) or IX (FIX; haemophilia B) causes haemophilia patients to suffer from spontaneous bleeding and excessive blood-loss following surgery or trauma. ...Haemophilia patients should be treated by a …
A deficiency of clotting factor VIII (FVIII; haemophilia A) or IX (FIX; haemophilia B) causes haemophilia patients to s …
Haemophilia B in Algeria: Realities and therapeutic perspectives.
Nekkal MS, Mesli N, Grifi F, Cherif N, Ouchenane Z, Bettayeb MS. Nekkal MS, et al. Haemophilia. 2023 Sep;29(5):1176-1183. doi: 10.1111/hae.14827. Epub 2023 Jul 19. Haemophilia. 2023. PMID: 37467156 Review.
AIMS: The aim of this manuscript is to raise awareness among patients and family clinicians about current practices, recent developments and unmet needs related to haemophilia B in Algeria. METHODS: A comprehensive literature search was conducted through online scientific …
AIMS: The aim of this manuscript is to raise awareness among patients and family clinicians about current practices, recent developments and …
Gene therapy for haemophilia A and B, from basic principles to clinical implementation: An illustrated review.
Ay C, Frenzel L, Pinachyan K, Le Quellec S. Ay C, et al. Haemophilia. 2024 Jan;30(1):5-15. doi: 10.1111/hae.14907. Epub 2023 Dec 18. Haemophilia. 2024. PMID: 38111029 Review.
INTRODUCTION: With recent approval of the first two gene therapies for haemophilia A and B, educational materials about AAV-based gene therapy are needed by the haemophilia community for a better understanding of this novel therapeutic approach and helping healthcar …
INTRODUCTION: With recent approval of the first two gene therapies for haemophilia A and B, educational materials about AAV-based gen …
Haemophilia B: Where are we now and what does the future hold?
Dolan G, Benson G, Duffy A, Hermans C, Jiménez-Yuste V, Lambert T, Ljung R, Morfini M, Zupančić Šalek S. Dolan G, et al. Blood Rev. 2018 Jan;32(1):52-60. doi: 10.1016/j.blre.2017.08.007. Epub 2017 Aug 16. Blood Rev. 2018. PMID: 28826659 Review.
Research has been lacking on the natural history, complications, and treatment of haemophilia B, which is less common than haemophilia A and was recognized as a distinct clinical entity in 1947. ...However, although fewer haemophilia B than haemophilia …
Research has been lacking on the natural history, complications, and treatment of haemophilia B, which is less common than haemoph …
Haemophilia care in China: Achievements in the past decade.
Dou X, Poon MC, Yang R. Dou X, et al. Haemophilia. 2020 Sep;26(5):759-767. doi: 10.1111/hae.14101. Epub 2020 Jul 14. Haemophilia. 2020. PMID: 32666580 Review.
There is a large population of people with haemophilia in China. However, the development of haemophilia care in China lagged far behind developed countries and was unbalanced across different regions. With the establishment of the Hemophilia Treatment Center Collab …
There is a large population of people with haemophilia in China. However, the development of haemophilia care in China lagged …
Musculoskeletal treatment in haemophilia.
Atilla B, Güney-Deniz H. Atilla B, et al. EFORT Open Rev. 2019 Jun 3;4(6):230-239. doi: 10.1302/2058-5241.4.180068. eCollection 2019 Jun. EFORT Open Rev. 2019. PMID: 31210965 Free PMC article. Review.
Haemophilia is a group of coagulation disorders inherited in an X-linked recessive pattern.Nearly three-quarters of all haemorrhages in haemophilia occur in the musculoskeletal system, usually in the large muscles and joints of the lower extremity.While prevention o …
Haemophilia is a group of coagulation disorders inherited in an X-linked recessive pattern.Nearly three-quarters of all haemorrhages …
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