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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2002 1
2003 1
2004 3
2005 1
2006 67
2007 148
2008 187
2009 221
2010 240
2011 242
2012 245
2013 249
2014 252
2015 199
2016 158
2017 192
2018 183
2019 66
2020 3
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2,371 results
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Page 1
The role of the Hedgehog signaling pathway in cancer: A comprehensive review.
Skoda AM, et al. Bosn J Basic Med Sci 2018 - Review. PMID 29274272 Free PMC article.
The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a highly conserved evolutionary pathway of signal transmission from the cell membrane to the nucleus. ...The components of the Hh signaling pathway involved in the signaling transfer to the Gli transcription factors include Hedgehog ligands (Sonic Hh [SHh], Indian Hh [IHh], and Desert Hh [DHh]), Patched receptor (Ptch1, Ptch2), Smoothened receptor (Smo), Suppressor of fused homolog (Sufu), kinesin protein Kif7, protein kinase A (PKA), and cyclic adenosine monophosphate (cAMP). ...
The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a highly conserved evolutionary pathway of si …
Introduction
Kruszka P, et al. Am J Med Genet C Semin Med Genet 2018. PMID 30182443
Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance.
Giroux-Leprieur E, et al. Int J Mol Sci 2018 - Review. PMID 30235830 Free PMC article.
In lung cancer, Hedgehog pathway is closely associated with cancer stem cells (CSCs). Recent works have shown that CSCs produced a full-length Sonic Hedgehog (Shh) protein, with paracrine activity and induction of tumor development. Hedgehog pathway is also involved in tumor drug resistance in lung cancer, as cytotoxic chemotherapy, radiotherapy, and targeted therapies. ...
In lung cancer, Hedgehog pathway is closely associated with cancer stem cells (CSCs). Recent works have shown that CSCs produced a fu …
Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.
Wang C, et al. J Clin Invest 2018. PMID 29999500 Free PMC article.
GWAS have repeatedly mapped susceptibility loci for emphysema to genes that modify hedgehog signaling, but the functional relevance of hedgehog signaling to this morbid disease remains unclear. In the current study, we identified a broad population of mesenchymal cells in the adult murine lung receptive to hedgehog signaling, characterized by higher activation of hedgehog surrounding the proximal airway relative to the distal alveoli. ...
GWAS have repeatedly mapped susceptibility loci for emphysema to genes that modify hedgehog signaling, but the functional relevance o …
A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.
Breslow DK, et al. Nat Genet 2018. PMID 29459677 Free PMC article.
Primary cilia organize Hedgehog signaling and shape embryonic development, and their dysregulation is the unifying cause of ciliopathies. We conducted a functional genomic screen for Hedgehog signaling by engineering antibiotic-based selection of Hedgehog-responsive cells and applying genome-wide CRISPR-mediated gene disruption. ...
Primary cilia organize Hedgehog signaling and shape embryonic development, and their dysregulation is the unifying cause of ciliopath …
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Katoh Y and Katoh M. Curr Mol Med 2009 - Review. PMID 19860666
Hedgehog signals are fine-tuned based on positive feedback loop via GLI1 and negative feedback loop via PTCH1, PTCH2, and HHIP1. ...Hedgehog signals induce cellular proliferation through upregulation of N-Myc, Cyclin D/E, and FOXM1. Hedgehog signals directly upregulate JAG2, indirectly upregulate mesenchymal BMP4 via FOXF1 or FOXL1, and also upregulate WNT2B and WNT5A. ...
Hedgehog signals are fine-tuned based on positive feedback loop via GLI1 and negative feedback loop via PTCH1, PTCH2, and HHIP1. ...
Sonic hedgehog in vertebrate neural tube development.
Placzek M and Briscoe J. Int J Dev Biol 2018. PMID 29616731 Free article.
Here we will focus on the role of Sonic hedgehog (Shh) signaling in coordinating the diversification, patterning, growth and differentiation of the vertebrate nervous system. ...
Here we will focus on the role of Sonic hedgehog (Shh) signaling in coordinating the diversification, patterning, growth and differen …
Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.
Bakshi A, et al. Mol Carcinog 2017 - Review. PMID 28574612 Free PMC article.
Basal cell carcinoma (BCC) of the skin is driven by aberrant hedgehog signaling. Thus blocking this signaling pathway by small molecules such as vismodegib inhibits tumor growth. Primary cilium in the epidermal cells plays an integral role in the processing of hedgehog signaling-related proteins. Recent genomic studies point to the involvement of additional genetic mutations that might be associated with the development of BCCs, suggesting significance of other signaling pathways, such as WNT, NOTCH, mTOR, and Hippo, aside from hedgehog in the pathogenesis of this human neoplasm. ...
Basal cell carcinoma (BCC) of the skin is driven by aberrant hedgehog signaling. Thus blocking this signaling pathway by small molecu …
Genomic testing, tumor microenvironment and targeted therapy of Hedgehog-related human cancers.
Katoh M. Clin Sci (Lond) 2019 - Review. PMID 31036756
Hedgehog signals are transduced through Patched receptors to the Smoothened (SMO)-SUFU-GLI and SMO-Gi-RhoA signaling cascades. ...Aberrant Hedgehog signaling in tumor cells leads to self-renewal, survival, proliferation and invasion. Paracrine Hedgehog signaling in the tumor microenvironment (TME), which harbors cancer-associated fibroblasts, leads to angiogenesis, fibrosis, immune evasion and neuropathic pain. ...
Hedgehog signals are transduced through Patched receptors to the Smoothened (SMO)-SUFU-GLI and SMO-Gi-RhoA signaling cascades. ...Abe
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