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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1952 1
1955 1
1956 1
1957 1
1958 2
1959 8
1960 2
1961 5
1962 5
1963 2
1964 7
1965 3
1967 2
1974 1
1975 5
1976 45
1977 118
1978 137
1979 208
1980 294
1981 266
1982 153
1983 116
1984 84
1985 78
1986 97
1987 83
1988 83
1989 76
1990 61
1991 43
1992 55
1993 56
1994 70
1995 45
1996 47
1997 52
1998 71
1999 68
2000 66
2001 46
2002 58
2003 48
2004 52
2005 45
2006 34
2007 48
2008 43
2009 36
2010 37
2011 44
2012 58
2013 50
2014 54
2015 48
2016 32
2017 35
2018 23
2019 20
2020 0
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3,248 results
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Page 1
A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition
Traxler EA, et al. Nat Med 2016. PMID 27525524 Free PMC article.
Disorders resulting from mutations in the hemoglobin subunit beta gene (HBB; which encodes β-globin), mainly sickle cell disease (SCD) and β-thalassemia, become symptomatic postnatally as fetal γ-globin expression from two paralogous genes, hemoglobin subunit gamma 1 (HBG1) and HBG2, decreases and adult β-globin expression increases, thereby shifting red blood cell (RBC) hemoglobin from the fetal (referred to as HbF or α2γ2) to adult (referred to as HbA or α2β2) form. ...For example, in hereditary persistence of fetal hemoglobin (HPFH), a benign genetic condition, mutations attenuate γ-globin-to-β-globin switching, causing high-level HbF expression throughout life. ...
Disorders resulting from mutations in the hemoglobin subunit beta gene (HBB; which encodes β-globin), mainly sickle cell disease (SCD …
Effect of Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex on Hemoglobin Concentration in Young Children With Nutritional Iron-Deficiency Anemia: A Randomized Clinical Trial.
Powers JM, et al. JAMA 2017 - Clinical Trial. PMID 28609534 Free PMC article.
OBJECTIVE: To compare the effect of ferrous sulfate with iron polysaccharide complex on hemoglobin concentration in infants and children with nutritional IDA. ...MAIN OUTCOMES AND MEASURES: Primary outcome was change in hemoglobin over 12 weeks. Secondary outcomes included complete resolution of IDA (defined as hemoglobin concentration >11 g/dL, mean corpuscular volume >70 fL, reticulocyte hemoglobin equivalent >25 pg, serum ferritin level >15 ng/mL, and total iron-binding capacity <425 μg/dL at the 12-week visit), changes in serum ferritin level and total iron-binding capacity, adverse effects. ...
OBJECTIVE: To compare the effect of ferrous sulfate with iron polysaccharide complex on hemoglobin concentration in infants and child …
Gene Therapy in a Patient with Sickle Cell Disease
Ribeil JA, et al. N Engl J Med 2017. PMID 28249145 Free article.
Sickle cell disease results from a homozygous missense mutation in the β-globin gene that causes polymerization of hemoglobin S. Gene therapy for patients with this disorder is complicated by the complex cellular abnormalities and challenges in achieving effective, persistent inhibition of polymerization of hemoglobin S. ...
Sickle cell disease results from a homozygous missense mutation in the β-globin gene that causes polymerization of hemoglobin S. Gene …
False measurement of glycated hemoglobin in patients without hemoglobin A.
Suo M, et al. Biosci Rep 2019. PMID 29720428 Free PMC article.
Background: Hemoglobin (Hb) A(1c), a biochemical marker widely used in monitoring diabetes mellitus, can be quantitatively measured by various examining systems. ...These results demonstrated that the limitations of current examining systems for monitoring patients with hemoglobin disorders highlighting the further improvement in the method of clinical HbA examination....
Background: Hemoglobin (Hb) A(1c), a biochemical marker widely used in monitoring diabetes mellitus, can be quantitatively measured b …
Red blood cell transfusion: a clinical practice guideline from the AABB*
Carson JL, et al. Ann Intern Med 2012 - Review. PMID 22751760
The AABB (formerly, the American Association of Blood Banks) developed this guideline to provide clinical recommendations about hemoglobin concentration thresholds and other clinical variables that trigger RBC transfusions in hemodynamically stable adults and children. ...RECOMMENDATION 4: The AABB suggests that transfusion decisions be influenced by symptoms as well as hemoglobin concentration (Grade: weak recommendation; low-quality evidence)....
The AABB (formerly, the American Association of Blood Banks) developed this guideline to provide clinical recommendations about hemoglobi
Hemoglobin: a gas transport molecule that is hormonally regulated in the ovarian follicle in mice and humans.
Brown HM, et al. Biol Reprod 2015. PMID 25395682
An increasing number of nonerythroid tissues are found to express hemoglobin mRNA and protein. Hemoglobin is a well-described gas transport molecule, especially for O2, but also for NO, CO2, and CO, and also acts as a reactive oxygen species scavenger. ...Several other genes involved in hemoglobin function were similarly luteinizing hormone-regulated, including genes for heme biosynthesis. ...
An increasing number of nonerythroid tissues are found to express hemoglobin mRNA and protein. Hemoglobin is a well-described …
Hemoglobin A clearance in children with sickle cell anemia on chronic transfusion therapy.
Yee MEM, et al. Transfusion 2018. PMID 29664198 Free PMC article.
BACKGROUND: Chronic transfusion therapy for sickle cell anemia reduces disease complications by diluting sickle-erythrocytes with hemoglobin A (HbA)-containing erythrocytes and suppressing erythropoiesis. ...
BACKGROUND: Chronic transfusion therapy for sickle cell anemia reduces disease complications by diluting sickle-erythrocytes with hemoglo
Carboxyhemoglobin: a primer for clinicians
Hampson NB. Undersea Hyperb Med 2018 - Review. PMID 29734568
One of carbon monoxide's several mechanisms of toxicity is binding with circulating hemoglobin to form carboxyhemoglobin, resulting in a functional anemia. ...
One of carbon monoxide's several mechanisms of toxicity is binding with circulating hemoglobin to form carboxyhemoglobin, resulting i …
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