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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 4
1983 16
1984 24
1985 31
1986 33
1987 41
1988 54
1989 53
1990 66
1991 63
1992 78
1993 81
1994 95
1995 74
1996 93
1997 112
1998 103
1999 110
2000 109
2001 142
2002 123
2003 137
2004 159
2005 117
2006 119
2007 120
2008 114
2009 102
2010 105
2011 104
2012 102
2013 95
2014 96
2015 84
2016 81
2017 47
2018 59
2019 16
2020 0
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2,971 results
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Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.
Gustafsen C, et al. Nat Commun 2017. PMID 28894089 Free PMC article.
Here, we show that liver heparan sulfate proteoglycans are PCSK9 receptors and essential for PCSK9-induced LDLR degradation. ...Here, Gustafsen et al. show that PCSK9 interacts with heparan sulfate proteoglycans and this binding favors LDLR degradation. ...
Here, we show that liver heparan sulfate proteoglycans are PCSK9 receptors and essential for PCSK9-induced LDLR degrada …
Heparan Sulfate Proteoglycans in Human Colorectal Cancer.
Vicente CM, et al. Anal Cell Pathol (Amst) 2018 - Review. PMID 30027065 Free PMC article.
Heparan sulfate proteoglycans are complex molecules present in the cell membrane and extracellular matrix, which play vital roles in cell adhesion, migration, proliferation, and signaling pathways. ...In addition, studies have reported increased heparan sulfate remodeling enzymes, as the endosulfatases. Therefore, heparan sulfate proteoglycans are candidate molecules to clarify colorectal cancer tumorigenesis, as well as important targets to therapy and diagnosis....
Heparan sulfate proteoglycans are complex molecules present in the cell membrane and extracellular matrix, which play v
Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).
Rauch JN, et al. Sci Rep 2018. PMID 29686391 Free PMC article.
Using CRISPRi technology we have tested 3200 genes for their ability to regulate tau entry and identified enzymes in the heparan sulfate proteoglycan biosynthetic pathway as key regulators. We show that 6-O-sulfation is critical for tau-heparan sulfate interactions and that this modification regulates uptake in human central nervous system cell lines, iPS-derived neurons, and mouse brain slice culture. ...
Using CRISPRi technology we have tested 3200 genes for their ability to regulate tau entry and identified enzymes in the heparan s
Heparan Sulfate Proteoglycans as Relays of Neuroinflammation.
O'Callaghan P, et al. J Histochem Cytochem 2018 - Review. PMID 29290138 Free PMC article.
Heparan sulfate proteoglycans (HSPGs) are implicated as inflammatory mediators in a variety of settings, including chemokine activation, which is required to recruit circulating leukocytes to infection sites. Heparan sulfate (HS) polysaccharide chains are highly interactive and serve co-receptor roles in multiple ligand:receptor interactions. ...
Heparan sulfate proteoglycans (HSPGs) are implicated as inflammatory mediators in a variety of settings, including chem
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds.
Holmes BB, et al. Proc Natl Acad Sci U S A 2013. PMID 23898162 Free PMC article.
Prior work indicates that prion protein aggregates bind heparan sulfate proteoglycans (HSPGs) on the cell surface to transmit pathologic processes. ...
Prior work indicates that prion protein aggregates bind heparan sulfate proteoglycans (HSPGs) on the cell surface to tr …
Heparan sulfate proteoglycans in Drosophila neuromuscular development.
Kamimura K and Maeda N. Biochim Biophys Acta Gen Subj 2017 - Review. PMID 28645846
Heparan sulfate proteoglycans (HSPGs) are glycoconjugates bearing heparan sulfate (HS) chains covalently attached to core proteins, which are ubiquitously distributed on the cell surface and in the extracellular matrix. ...
Heparan sulfate proteoglycans (HSPGs) are glycoconjugates bearing heparan sulfate (HS) chains covalently
The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis.
Gordts PLSM and Esko JD. Matrix Biol 2018 - Review. PMID 29803939 Free PMC article.
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of proteins involved in lipid homeostasis and inflammation. ...Here, we discuss novel insights into how heparan sulfate proteoglycans modulate risk factors such as hyperlipidemia and inflammation that drive the initiation and progression of atherosclerotic plaques to their clinical critical endpoint....
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a
Heparan sulfate proteoglycans: a sugar code for vertebrate development?
Poulain FE and Yost HJ. Development 2015 - Review. PMID 26487777 Free PMC article.
Heparan sulfate proteoglycans (HSPGs) have long been implicated in a wide range of cell-cell signaling and cell-matrix interactions, both in vitro and in vivo in invertebrate models. ...Here, we provide a comprehensive overview of the various roles of HSPGs in these systems and explore the concept of an instructive heparan sulfate sugar code for modulating vertebrate development....
Heparan sulfate proteoglycans (HSPGs) have long been implicated in a wide range of cell-cell signaling and cell-matrix
Heparan sulfate proteoglycans regulate autophagy in Drosophila.
Reynolds-Peterson CE, et al. Autophagy 2017. PMID 28402693 Free PMC article.
Heparan sulfate-modified proteoglycans (HSPGs) are important regulators of signaling and molecular recognition at the cell surface and in the extracellular space. ...
Heparan sulfate-modified proteoglycans (HSPGs) are important regulators of signaling and molecular recognition at the c
Heparan sulfate proteoglycans undergo differential expression alterations in left sided colorectal cancer, depending on their metastatic character.
Crespo A, et al. BMC Cancer 2018. PMID 29940912 Free PMC article.
BACKGROUND: Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells. ...METHODS: Eighteen LSCRCs were studied using qPCR to analyze the expression of both the proteoglycan core proteins and the enzymes involved in heparan sulfate chain biosynthesis. ...
BACKGROUND: Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth an …
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