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Year Number of Results
2006 1
2007 2
2008 29
2009 74
2010 56
2011 82
2012 76
2013 104
2014 91
2015 108
2016 118
2017 122
2018 117
2019 55
2020 1
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886 results
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Page 1
Hepatic stellate cells as key target in liver fibrosis.
Higashi T, et al. Adv Drug Deliv Rev 2017 - Review. PMID 28506744 Free PMC article.
Transdifferentiation (or "activation") of hepatic stellate cells is the major cellular source of matrix protein-secreting myofibroblasts, the major driver of liver fibrogenesis. ...Dysregulated intracellular signaling, epigenetic changes, and cellular stress response represent candidate targets to deactivate stellate cells by inducing reversion to inactivated state, cellular senescence, apoptosis, and/or clearance by immune cells. ...
Transdifferentiation (or "activation") of hepatic stellate cells is the major cellular source of matrix protein-secreti …
Hepatic stellate cells and liver fibrosis.
Puche JE, et al. Compr Physiol 2013 - Review. PMID 24265236
Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a remarkable range of functions in normal and injured liver. Derived embryologically from septum transversum mesenchyme, their precursors include submesothelial cells that invade the liver parenchyma from the hepatic capsule. ...
Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a remarkable ran
Mechanisms of hepatic stellate cell activation.
Tsuchida T and Friedman SL. Nat Rev Gastroenterol Hepatol 2017 - Review. PMID 28487545
Activation of hepatic stellate cells (HSCs) - transdifferentiation of quiescent, vitamin-A-storing cells into proliferative, fibrogenic myofibroblasts - is now well established as a central driver of fibrosis in experimental and human liver injury. ...Extracellular signals from resident and inflammatory cells including macrophages, hepatocytes, liver sinusoidal endothelial cells, natural killer cells, natural killer T cells, platelets and B cells further modulate HSC activation. ...
Activation of hepatic stellate cells (HSCs) - transdifferentiation of quiescent, vitamin-A-storing cells into pr …
Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis.
Coll M, et al. Cell Stem Cell 2018. PMID 30049452 Free article.
The development of complex in vitro hepatic systems and artificial liver devices has been hampered by the lack of reliable sources for relevant cell types, such as hepatic stellate cells (HSCs). Here we report efficient differentiation of human pluripotent stem cells into HSC-like cells (iPSC-HSCs). iPSC-HSCs closely resemble primary human HSCs at the transcriptional, cellular, and functional levels and possess a gene expression profile intermediate between that of quiescent and activated HSCs. ...
The development of complex in vitro hepatic systems and artificial liver devices has been hampered by the lack of reliable sources fo …
Modulation of hepatic stellate cells and reversibility of hepatic fibrosis.
Huang Y, et al. Exp Cell Res 2017 - Review. PMID 28238836
Hepatic fibrosis (HF) is the pathological component of a variety of chronic liver diseases. Hepatic stellate cells (HSC) are the main collagen-producing cells in the liver and their activation promotes HF. ...
Hepatic fibrosis (HF) is the pathological component of a variety of chronic liver diseases. Hepatic stellate cells
Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia-reperfusion injury.
Konishi T, et al. Am J Physiol Gastrointest Liver Physiol 2018. PMID 29351389 Free PMC article.
After liver injury, there was marked activation and proliferation of hepatic stellate cells. The Hippo pathway components, large tumor suppressor 1 (LATS1) and its adapter protein, Mps one binder 1 (MOB1), were inactivated during liver repair, and YAP and TAZ were activated selectively in hepatic stellate cells. ...NEW & NOTEWORTHY This study is the first to assess the proliferation of hepatic stellate cells (HSCs) after ischemia-reperfusion (I/R) injury and their role in the reparative and regenerative process. ...
After liver injury, there was marked activation and proliferation of hepatic stellate cells. The Hippo pathway componen …
Hepatic stellate cells contribute to progenitor cells and liver regeneration.
Kordes C, et al. J Clin Invest 2014. PMID 25401473 Free PMC article.
Retinoid-storing hepatic stellate cells (HSCs) have recently been described as a liver-resident mesenchymal stem cell (MSC) population; however, it is not clear whether these cells contribute to liver regeneration or serve as a progenitor cell population with hepatobiliary characteristics. ...Cultured HSCs transiently adopted an expression profile similar to that of progenitor cells during differentiation into bile acid-synthesizing and -transporting hepatocytes, suggesting that stellate cells represent a source of liver progenitor cells. ...
Retinoid-storing hepatic stellate cells (HSCs) have recently been described as a liver-resident mesenchymal stem cell ( …
Management strategies for liver fibrosis
Altamirano-Barrera A, et al. Ann Hepatol 2017 - Review. PMID 28051792 Free article.
The response of hepatocytes to inflammation plays a decisive role in the physiopathology of hepatic fibrosis, which involves the recruitment of both pro- and anti-inflammatory cells such as monocytes and macrophages. As well as the production of other cytokines and chemokines, which increase the stimulus of hepatic stellate cells by activating proinflammatory cells. ...
The response of hepatocytes to inflammation plays a decisive role in the physiopathology of hepatic fibrosis, which involves the recr …
Stellate Cells in Tissue Repair, Inflammation, and Cancer.
Sherman MH. Annu Rev Cell Dev Biol 2018 - Review. PMID 30028641
Stellate cells are resident lipid-storing cells of the pancreas and liver that transdifferentiate to a myofibroblastic state in the context of tissue injury. ...Although the capacity of stellate cells for extracellular matrix production and remodeling has long been appreciated, recent research efforts have demonstrated diverse roles for stellate cells in regulation of epithelial cell fate, immune modulation, and tissue health. ...
Stellate cells are resident lipid-storing cells of the pancreas and liver that transdifferentiate to a myofibroblastic
Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers.
Lua I, et al. J Hepatol 2016. PMID 26806818 Free PMC article.
BACKGROUND & AIMS: Contribution of hepatic stellate cells (HSCs), portal fibroblasts (PFs), and mesothelial cells (MCs) to myofibroblasts is not fully understood due to insufficient availability of markers and isolation methods. The present study aimed to isolate these cells, characterize their phenotypes, and examine their contribution to myofibroblasts in liver fibrosis. ...
BACKGROUND & AIMS: Contribution of hepatic stellate cells (HSCs), portal fibroblasts (PFs), and mesothelial cell
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