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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 3
1971 3
1973 1
1974 3
1975 26
1976 108
1977 396
1978 397
1979 484
1980 489
1981 497
1982 480
1983 532
1984 566
1985 583
1986 584
1987 545
1988 515
1989 518
1990 533
1991 516
1992 480
1993 405
1994 385
1995 374
1996 347
1997 323
1998 313
1999 311
2000 322
2001 317
2002 376
2003 394
2004 382
2005 436
2006 423
2007 461
2008 451
2009 492
2010 546
2011 564
2012 591
2013 656
2014 651
2015 665
2016 616
2017 602
2018 573
2019 265
2020 3
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19,611 results
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Page 1
Hepatitis B virus infection: Defective surface antigen expression and pathogenesis.
Wu CC, et al. World J Gastroenterol 2018 - Review. PMID 30131655 Free PMC article.
Hepatitis B virus (HBV) infection is a global public health concern. HBV causes chronic infection in patients and can lead to liver cirrhosis, hepatocellular carcinoma, and other severe liver diseases. ...In this review, we focus our discussion on the nature of defective HBV surface antigen mutations and their contribution to the pathogenesis of fulminant hepatitis B. ...
Hepatitis B virus (HBV) infection is a global public health concern. HBV causes chronic infection in patients and can lead to liver c
Circulating and intrahepatic antiviral B cells are defective in hepatitis B.
Burton AR, et al. J Clin Invest 2018 - Clinical Trial. PMID 30091725 Free PMC article.
B cells are increasingly recognized as playing an important role in the ongoing control of hepatitis B virus (HBV). The development of antibodies against the viral surface antigen (HBV surface antigen [HBsAgs]) constitutes the hallmark of resolution of acute infection and is a therapeutic goal for functional cure of chronic HBV (CHB). ...
B cells are increasingly recognized as playing an important role in the ongoing control of hepatitis B virus (HBV). The development o …
Treatment of chronic hepatitis B naïve patients with a therapeutic vaccine containing HBs and HBc antigens (a randomized, open and treatment controlled phase III clinical trial).
Al Mahtab M, et al. PLoS One 2018 - Clinical Trial. PMID 30133478 Free PMC article.
CONTEXT: Current drugs for chronic hepatitis B therapy have a poor efficacy in terms of post-treatment sustained viral suppression and generate important side effects during and after therapy. ...OBJECTIVE: Evaluating the efficacy of a therapeutic vaccine candidate (designated NASVAC) containing both hepatitis B surface antigen (HBsAg) and core antigen (HBcAg) versus pegylated interferon (Peg-IFN) in naïve chronic hepatitis B patients. ...
CONTEXT: Current drugs for chronic hepatitis B therapy have a poor efficacy in terms of post-treatment sustained viral suppression an …
Hepatitis B Surface Antigen Seroprevalence among Prevaccine and Vaccine Era Children in Bangladesh.
Paul RC, et al. Am J Trop Med Hyg 2018. PMID 30014817 Free PMC article.
Bangladesh introduced hepatitis B vaccine in a phased manner during 2003-2005 into the routine childhood vaccination schedule. This study was designed to evaluate the impact of the introduction of hepatitis B vaccine in Bangladesh by comparing hepatitis B surface antigen (HBsAg) prevalence among children born before and after vaccine introduction and to estimate the risk of vertical transmission of chronic hepatitis B virus (HBV) infection from mother to infant. ...
Bangladesh introduced hepatitis B vaccine in a phased manner during 2003-2005 into the routine childhood vaccination schedule. This s …
PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection.
Salimzadeh L, et al. J Clin Invest 2018 - Clinical Trial. PMID 30084841 Free PMC article.
Here, we developed a dual-staining method that utilizes hepatitis B virus (HBV) surface antigens (HBsAg) labeled with fluorochromes as "baits" for specific ex vivo detection of HBsAg-specific B cells and analysis of their quantity, function, and phenotype. ...
Here, we developed a dual-staining method that utilizes hepatitis B virus (HBV) surface antigens (HBsAg) labeled with fluorochromes a …
Cytokine and chemokine signatures associated with hepatitis B surface antigen loss in hepatitis B patients.
Yoshio S, et al. JCI Insight 2018. PMID 30333304 Free PMC article.
BACKGROUND: The clearance of hepatitis B surface antigen (HBsAg) loss, defined as functional cure, is a clinical target in patients with chronic hepatitis B (CH). ...RESULTS: In AH patients and HBV-inoculated chimpanzees with HBsAg loss, CXCL9, CXCL10, CXCL11, CXCL13, and IL-21 were elevated at hepatitis with subsequent decline of HBsAg. ...
BACKGROUND: The clearance of hepatitis B surface antigen (HBsAg) loss, defined as functional cure, is a clinical target in patients w …
Entering the spotlight: hepatitis B surface antigen-specific B cells.
Neumann-Haefelin C and Thimme R. J Clin Invest 2018. PMID 30222139 Free PMC article.
Hepatitis B virus-specific (HBV-specific) T cells have been identified as main effector cells in HBV clearance. In contrast, B cells producing neutralizing antibodies against the HBV surface antigen (HBsAg) have been studied in little detail, mainly due to methodical limitations. ...
Hepatitis B virus-specific (HBV-specific) T cells have been identified as main effector cells in HBV clearance. In contrast, B cells
Blood donor testing for hepatitis B virus in the United States: is there a case for continuation of hepatitis B surface antigen detection?
Dodd RY, et al. Transfusion 2018. PMID 30144082
BACKGROUND: In the United States, blood donor testing for hepatitis B surface antigen (HBsAg) was initiated in the early 1970s. More recently, testing for antibody to hepatitis B core antigen (anti-HBc) and hepatitis B virus (HBV) DNA have been added. The incidence of hepatitis B has been declining. ...
BACKGROUND: In the United States, blood donor testing for hepatitis B surface antigen (HBsAg) was initiated in the early 1970s. More …
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