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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 3
1998 13
1999 9
2000 17
2001 16
2002 27
2003 37
2004 26
2005 38
2006 31
2007 35
2008 40
2009 42
2010 54
2011 123
2012 136
2013 109
2014 109
2015 107
2016 87
2017 70
2018 52
2019 25
2020 1
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1,072 results
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Page 1
Host - hepatitis C viral interactions: The role of genetics.
Heim MH, et al. J Hepatol 2016 - Review. PMID 27641986
Hepatitis C virus (HCV) is a major cause of chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. ...Individuals with the ancestral IFNλ4 allele capable of producing a fully active IFNλ4 are paradoxically not able to clear HCV in the acute phase and develop chronic hepatitis C (CHC) with more than 90% probability. ...
Hepatitis C virus (HCV) is a major cause of chronic viral hepatitis that can lead to cirrhosis and hepatocellula
Mannose-binding lectin in chronic hepatitis C in children.
Dzwonek AB, et al. Scand J Gastroenterol 2015. PMID 25956563
OBJECTIVE: To investigate effect of mannose-binding lectin (MBL) genetic polymorphisms and phenotype in chronic hepatitis C and its impact on response to antiviral therapy in children. METHODS: Fifty four children with chronic hepatitis C, aged 2.5-18 years were enrolled. Forty-five children were treated with interferon-α (IFN-α) alone (n = 2) or IFN-α and ribavirin (n = 43). ...
OBJECTIVE: To investigate effect of mannose-binding lectin (MBL) genetic polymorphisms and phenotype in chronic hepatitis C
Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis.
Guo P, et al. BMC Infect Dis 2019. PMID 31470810 Free PMC article.
BACKGROUND: Although several researches have reported the connection between the transforming growth factor-beta 1 (TGF-β1) gene polymorphisms and chronic hepatitis C virus (HCV) infection, the conclusions of these studies were not always consistent. ...However, our meta-analysis did not find any significant association between the codon 10 T/C or codon 25G/C polymorphisms and chronic HCV infection. ...
BACKGROUND: Although several researches have reported the connection between the transforming growth factor-beta 1 (TGF-β1) gene polymorphis …
MDR1 gene C3435T polymorphism in chronic hepatitis C patients.
Parsa Nahad M, et al. Microb Pathog 2018. PMID 29155127
METHODS: The peripheral blood-EDTA samples were collected from 71 patients with chronic hepatitis C. The total genomic DNA extraction was carried out. ...The homozygous TT genotype and high prevalence of T allele may be related to low antiviral response during combined therapy in treatment of chronic HCV patients....
METHODS: The peripheral blood-EDTA samples were collected from 71 patients with chronic hepatitis C. The total genomic …
Pangenotypic treatment regimens for chronic hepatitis C.
Urbánek P. Vnitr Lek 2019. PMID 31635466
The treatment of chronic hepatitis C is currently based exclusively on the use of drugs from the direct-acting anti-viral class. ...Pangenotypic regimens probably represent the latest stage of development of treatment for chronic hepatitis C. The review discusses in detail the efficiency of different pangenotypic regimens in individual subgroups of patients with HCV infection. ...
The treatment of chronic hepatitis C is currently based exclusively on the use of drugs from the direct-acting anti-vir …
[Investigation of the association between chronic hepatitis B and C infections and TNF-α (-308) gene polymorphism].
Börekçi G, et al. Mikrobiyol Bul 2016. PMID 27175496 Turkish. Free article.
Cytokines and genetic factors play important roles in the pathogenesis of chronic hepatitis B (CHB) and chronic hepatitis C (CHC) infections. ...Further studies on this subject would contribute to the elucidation of the molecular mechanisms of chronic hepatitis B and C diseases....
Cytokines and genetic factors play important roles in the pathogenesis of chronic hepatitis B (CHB) and chronic hepa
Understanding the host genetics of chronic hepatitis B and C.
Thursz M, et al. Semin Liver Dis 2011 - Review. PMID 21538279
The outcome of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are heterogeneous, ranging from an asymptomatic self-limiting infection to cirrhosis and hepatocellular carcinoma. ...Translation of the genetic architecture of chronic viral hepatitis into therapeutic opportunities has been slow to proceed. One clinical trial and one drug development program have been based on genetic discoveries. ...
The outcome of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are heterogeneous, ranging from an asympt …
Distribution of IL28B rs12979860 and rs8099917 Genotypes in Patients with Chronic Hepatitis C Virus Infection in Tianjin, China.
Qiao K, et al. Clin Lab 2018. PMID 29739095
BACKGROUND: Two single-nucleotide polymorphisms (SNPs) rs12979860 (C/T) and rs8099917 (T/G), near the interleukin 28B (IL28B, also known as IFN lambda-3, IFNL3) gene, have a strong association with both spontaneous and treatment-induced hepatitis C virus (HCV) clearance. ...The study aimed to investigate the distribution of IL28B rs12979860 and rs8099917 genotypes in patients with chronic hepatitis C (CHC) in Tianjin, China. ...
BACKGROUND: Two single-nucleotide polymorphisms (SNPs) rs12979860 (C/T) and rs8099917 (T/G), near the interleukin 28B (IL28B, also kn …
Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C.
Araújo RC, et al. J Immunol Res 2018. PMID 29951556 Free PMC article.
Hepatitis C virus (HCV) can escape from innate and adaptive immunity, making the immune response ineffective. Human leukocyte antigen E (HLA-E) might regulate the antiviral function of immune response and contribute to the persistence of HCV and the severity of liver disease. ...It indicates that HLA-E expression may have an immunomodulatory effect and a possible role in the severity of liver disease in chronic hepatitis C....
Hepatitis C virus (HCV) can escape from innate and adaptive immunity, making the immune response ineffective. Human leukocyte
Single nucleotide polymorphism rs1800872 in the promoter region of the IL10 gene is associated with predisposition to chronic hepatitis C in Russian population.
Barkhash AV, et al. Microbes Infect 2018. PMID 29247709
In this study, a possible involvement of these SNPs in the development of predisposition to chronic hepatitis C (caused by structurally similar, related virus from the Flaviviridae family) was investigated in the same population. Only the IL10 promoter rs1800872 SNP was associated with predisposition to chronic hepatitis C. This SNP seems to be a common genetic marker of predisposition to two diseases caused by hepatitis C and tick-borne encephalitis viruses in Russian population....
In this study, a possible involvement of these SNPs in the development of predisposition to chronic hepatitis C (caused …
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