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Napsin A, Hepatocyte Nuclear Factor-1-Beta (HNF-1β), Estrogen and Progesterone Receptors Expression in Arias-Stella Reaction.
Ip PPC, et al. Am J Surg Pathol 2019. PMID 30608233
A panel of immunohistochemical markers comprising napsin A, hepatocyte nuclear factor-1-beta (HNF-1β), estrogen and progesterone receptors (ER, PR) has been found useful in confirming a diagnosis of ECCC. ...For napsin A, any cytoplasmic staining was considered positive while only nuclear staining was deemed to be positive for HNF-1β, ER, and PR. ...
A panel of immunohistochemical markers comprising napsin A, hepatocyte nuclear factor-1-beta (HNF-1β), es …
Diagnostic value of dual detection of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diagnosing ovarian clear cell carcinoma.
Li Q, et al. Int J Clin Exp Pathol 2015. PMID 26339401 Free PMC article.
We evaluated the diagnostic value of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diagnosing ovarian clear cell carcinoma. ...
We evaluated the diagnostic value of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diagnosin …
Clear cell carcinoma of the pancreas: histopathologic features and a unique biomarker: hepatocyte nuclear factor-1beta.
Kim L, et al. Mod Pathol 2008. PMID 18536653 Free article.
Hepatocyte nuclear factor-1beta as a transcription factor has been identified as a specific biomarker of clear cell tumor of the female genital tract. The aim of this study was to systematically analyze clear cell carcinoma of the pancreas and its unique biomarker hepatocyte nuclear factor-1beta. ...
Hepatocyte nuclear factor-1beta as a transcription factor has been identified as a specific biomarker of clear c
Hepatocyte nuclear factor 1β is a novel prognostic marker independent of the Milan criteria in transplantable hepatocellular carcinoma: a retrospective analysis based on tissue microarrays.
Shim JH, et al. Liver Transpl 2013. PMID 23203386 Free article.
We retrospectively investigated the prognostic value of hepatocyte nuclear factor 1 (HNF1) proteins in 159 liver transplant patients with hepatocellular carcinoma (HCC), including 36 (22.6%) exceeding the Milan criteria. ...A subgroup analysis showed that in the group meeting the Milan criteria, recurrence and cancer death rates at 10 years in the HNF1β-negative patients were approximately one-tenth of those in the HNF1β-positive patients, but the difference was not significant in the group exceeding the Milan criteria. ...
We retrospectively investigated the prognostic value of hepatocyte nuclear factor 1 (HNF1) proteins in 159 liver …
Hepatocyte nuclear factor-1β is not a specific marker of clear cell carcinoma in serous effusions.
Davidson B. Cancer Cytopathol 2014. PMID 24115587 Free article.
BACKGROUND: The transcription factor hepatocyte nuclear factor-1β (HNF1β) has been reported to be a specific clear cell carcinoma marker, but its role in the diagnosis of serous effusions is largely unexplored. ...Distinct nuclear expression of HNF1β was observed in lung and gastrointestinal carcinomas, most often using the Atlas antibody. ...
BACKGROUND: The transcription factor hepatocyte nuclear factor-1β (HNF1β) has been reported to be a specific cle …
Expanded clinical spectrum in hepatocyte nuclear factor 1b-maturity-onset diabetes of the young.
Raile K, et al. J Clin Endocrinol Metab 2009. PMID 19417042
AIMS: HNF1B-maturity-onset diabetes of the young is caused by abnormalities in the HNF1B gene encoding the transcription factor HNF-1beta. ...Whole genome array comparative genomic hybridization confirmed a precurrent genomic deletion of approximately 1.3-1.7 Mb in size. ...
AIMS: HNF1B-maturity-onset diabetes of the young is caused by abnormalities in the HNF1B gene encoding the transcription factor HNF-1 …
Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors
Rougemont AL and Tille JC. Hum Pathol 2018. PMID 29753846
HNF1β nuclear reactivity was seen in the YST component in all 49 tumors, with a moderate to strong nuclear pattern of staining. ...Choriocarcinoma (6/6) showed faint focal cytoplasmic reactivity to HNF1β but no nuclear staining. In teratomas, only enteric-type glands showed nuclear reactivity to HNF1β (11/16). ...
HNF1β nuclear reactivity was seen in the YST component in all 49 tumors, with a moderate to strong nuclear pattern of staining …
Clinicopathological heterogeneity in ovarian clear cell adenocarcinoma: a study on individual therapy practice
Matsuo Y, et al. Med Mol Morphol 2015. PMID 25398420
Immunohistochemical analysis for expression of ARID1A, p53, PTEN, Annexin 4, hepatocyte nuclear factor-1β (HNF-1β), and WT-1 was employed. ...Furthermore, immunohistochemical analysis may shed light on the selection of appropriate treatment, including chemotherapy....
Immunohistochemical analysis for expression of ARID1A, p53, PTEN, Annexin 4, hepatocyte nuclear factor-1β (HNF-1 …
Expression of HNF-1β in cervical carcinomas: an immunohistochemical study of 155 cases
Němejcová K, et al. Diagn Pathol 2015. PMID 25884453 Free PMC article.
However, a systematic analysis of HNF-1β expression in cervical carcinomas has not been performed to date. METHODS: We analyzed HNF-1β expression in 155 cervical carcinomas (including 56 adenocarcinomas, 85 squamous cell carcinomas and 14 undifferentiated carcinomas). ...Undifferentiated carcinomas showed expression of HNF-1β in 2/14 cases (14.3%), CEA in 8/14 cases (57.1%), p16 in 14/14 cases (100%), hormone receptors in 0/13 cases (0%), p63 in 7/14 cases (50%), p40 in 5/14 cases (35.7%), and D2-40 in 1/14 cases (7.1%). ...
However, a systematic analysis of HNF-1β expression in cervical carcinomas has not been performed to date. METHODS: We analyzed HNF-1 …
Ovarian cancers arising from endometriosis: a microenvironmental biomarker study including ER, HNF1ß, p53, PTEN, BAF250a, and COX-2
Lai CR, et al. J Chin Med Assoc 2013. PMID 23962610 Free article.
METHODS: Our study used immunohistochemistry to compare the expression of estrogen receptor (ER), hepatocyte nuclear factor-1 beta (HNF1ß), p53, phosphatase and tensin homolog (PTEN), BAF250a, and cyclooxygenase-2 (COX-2) among 79 cases of endometriosis-associated ovarian cancers, including 40 (50%) clear cell carcinomas (CCCs), 33 (41%) endometrioid (EM) adenocarcinomas, four (5%) serous carcinomas, one adenosquamous carcinoma, and one adenosarcoma. ...
METHODS: Our study used immunohistochemistry to compare the expression of estrogen receptor (ER), hepatocyte nuclear factor
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