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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1999 1
2000 15
2001 39
2002 45
2003 42
2004 43
2005 53
2006 71
2007 43
2008 50
2009 39
2010 28
2011 43
2012 36
2013 38
2014 35
2015 35
2016 33
2017 36
2018 24
2019 7
2020 0
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678 results
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Page 1
The constitutive lipid droplet protein PLIN2 regulates autophagy in liver
Tsai TH, et al. Autophagy 2017. PMID 28548876 Free PMC article.
The enhanced autophagy in plin2(-/-) mice protects against severe ER stress-induced hepatosteatosis and hepatocyte apoptosis. ...
The enhanced autophagy in plin2(-/-) mice protects against severe ER stress-induced hepatosteatosis and hepatocyte apoptosis. ...
Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.
Nair JK, et al. J Am Chem Soc 2014. PMID 25434769 Free article.
Conjugation of small interfering RNA (siRNA) to an asialoglycoprotein receptor ligand derived from N-acetylgalactosamine (GalNAc) facilitates targeted delivery of the siRNA to hepatocytes in vitro and in vivo. ...Refinement of the siRNA chemistry achieved a 5-fold improvement in efficacy over the parent design in vivo with a median effective dose (ED50) of 1 mg/kg following a single dose. ...
Conjugation of small interfering RNA (siRNA) to an asialoglycoprotein receptor ligand derived from N-acetylgalactosamine (GalNAc) facilitate …
Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH.
Ioannou GN, et al. J Lipid Res 2017. PMID 28404639 Free PMC article.
We recently reported that cholesterol crystals form in hepatocyte lipid droplets (LDs) in human and experimental nonalcoholic steatohepatitis. ...In conclusion, cholesterol crystals form on the LD membrane of hepatocytes and cause activation and cholesterol loading of KCs that surround and process these LDs by lysosomal enzymes....
We recently reported that cholesterol crystals form in hepatocyte lipid droplets (LDs) in human and experimental nonalcoholic steatoh …
Sidt2 regulates hepatocellular lipid metabolism through autophagy
Chen X, et al. J Lipid Res 2018. PMID 29363559 Free PMC article.
First, it was observed that food consumption, hepatocyte fatty acid uptake and de novo lipogenesis, hepatocyte lipolysis, and TG secretion in the form of very low density lipoprotein were comparable between Sidt2(-/-) and WT mice. ...In addition, the classical autophagy pathway marker proteins, p62 and LC3-II, increased in liver, along with compromised autophagic flux in primary hepatocytes, indicating a block of autophagosome maturation due to Sidt2 deficiency, which was also supported by electron microscopy image analysis both in livers and in primary hepatocytes from Sidt2(-/-) mice. ...
First, it was observed that food consumption, hepatocyte fatty acid uptake and de novo lipogenesis, hepatocyte lipolysis, and …
Ezetimibe inhibits dengue virus infection in Huh-7 cells by blocking the cholesterol transporter Niemann-Pick C1-like 1 receptor
Osuna-Ramos JF, et al. Antiviral Res 2018. PMID 30391500
Ezetimibe is an FDA-approved drug that reduces cholesterol uptake by inhibiting the endocytosis through Niemman-Pick C1-Like 1 (NPC1L1) receptor, expressed on the membrane of enterocytes and hepatocytes. ...
Ezetimibe is an FDA-approved drug that reduces cholesterol uptake by inhibiting the endocytosis through Niemman-Pick C1-Like 1 (NPC1L1) rece …
Targeted LC-MS/MS Proteomics-Based Strategy To Characterize in Vitro Models Used in Drug Metabolism and Transport Studies
Xu M, et al. Anal Chem 2018. PMID 30204418 Free PMC article.
Further, analysis of exosomes isolated from sandwich-cultured hepatocyte media showed the effect of culture duration on compositions of purified exosomes. ...
Further, analysis of exosomes isolated from sandwich-cultured hepatocyte media showed the effect of culture duration on compositions …
Expression of cytochrome P450 mRNAs in Type II alveolar cells from subjects with chronic obstructive pulmonary disease
Kamata S, et al. Pharmacol Res Perspect 2018. PMID 29850024 Free PMC article.
Although most CYP genes are highly expressed in primary hepatocytes, we found that CYP1B1 mRNA expression was 7.2-fold higher in ATII compared to hepatocytes (P = .0275). ...
Although most CYP genes are highly expressed in primary hepatocytes, we found that CYP1B1 mRNA expression was 7.2-fold higher in ATII …
Gene expression profiling of human hepatocytes grown on differing substrate stiffness.
Xia T, et al. Biotechnol Lett 2018. PMID 29605939
OBJECTIVE: To study the effects of different substrate stiffness on human hepatocytes using RNA sequencing (RNA-Seq) technology. ...RESULTS: With the aid of RNA-Seq technology, our study characterizes the transcriptome of hepatocytes cultured on soft, moderate, stiff and plastic substrates. ...
OBJECTIVE: To study the effects of different substrate stiffness on human hepatocytes using RNA sequencing (RNA-Seq) technology. ...R …
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