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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1974 1
1976 1
1977 1
1980 2
1981 3
1983 1
1984 1
1992 1
1993 1
1994 3
1995 3
1997 5
1998 6
1999 7
2000 289
2001 829
2002 797
2003 879
2004 929
2005 1065
2006 1112
2007 1123
2008 1184
2009 1127
2010 1192
2011 1263
2012 1350
2013 1417
2014 1503
2015 1448
2016 1464
2017 1462
2018 1369
2019 597
2020 14
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19,775 results
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Page 1
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.
Puchalska P and Crawford PA. Cell Metab 2017 - Review. PMID 28178565 Free PMC article.
Ketone body metabolism is a central node in physiological homeostasis. In this review, we discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and organism performance in varying nutrient states and protect from inflammation and injury in multiple organ systems. ...Controversies in ketone metabolism and signaling are discussed to reconcile classical dogma with contemporary observations....
Ketone body metabolism is a central node in physiological homeostasis. In this review, we discuss how ketones serve discrete fine-tun …
Pathogenesis of Nonalcoholic Steatohepatitis
Machado MV and Diehl AM. Gastroenterology 2016 - Review. PMID 26928243 Free PMC article.
Nonalcoholic steatohepatitis (NASH) is a necro-inflammatory response that ensues when hepatocytes are injured by lipids (lipotoxicity). NASH is a potential outcome of nonalcoholic fatty liver (NAFL), a condition that occurs when lipids accumulate in hepatocytes. ...
Nonalcoholic steatohepatitis (NASH) is a necro-inflammatory response that ensues when hepatocytes are injured by lipids (lipotoxicity …
Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method.
Salem ESB, et al. J Vis Exp 2018. PMID 30417869 Free PMC article.
Herein we describe a method for the isolation and culture of primary mouse hepatocytes by performing a two-step collagenase perfusion technique and discuss their utilization for investigating protein metabolism. ...These hepatocytes can be used for assessments of protein metabolism including nascent protein synthesis with non-radioactive reagents. ...
Herein we describe a method for the isolation and culture of primary mouse hepatocytes by performing a two-step collagenase perfusion …
[Effect of lipid-induced macrophage M1/M2 polarization on lipid metabolism in hepatocytes].
Wang Q, et al. Zhonghua Gan Zang Bing Za Zhi 2018. PMID 29996339 Chinese.
Objective: This study aims to explore the effect of lipid-induced macrophage M1/M2 polarization on lipid metabolism in hepatocytes. ...Conclusion: Different fatty acids affect the balance of lipid metabolism in hepatocytes and liver by inducing macrophage M1 / M2 polarization, thus promoting or delaying the progression of non-alcoholic fatty liver disease....
Objective: This study aims to explore the effect of lipid-induced macrophage M1/M2 polarization on lipid metabolism in hepatocytes
Structural and functional hepatocyte polarity and liver disease.
Gissen P and Arias IM. J Hepatol 2015 - Review. PMID 26116792 Free PMC article.
Establishment and maintenance of hepatocyte polarity is essential for many functions of hepatocytes and requires carefully orchestrated cooperation between cell adhesion molecules, cell junctions, cytoskeleton, extracellular matrix and intracellular trafficking machinery. ...Thus both structural and functional components contribute to the final hepatocyte polarity phenotype. Many acquired liver diseases target factors that determine hepatocyte polarity, such as junctional proteins. ...
Establishment and maintenance of hepatocyte polarity is essential for many functions of hepatocytes and requires carefully orc …
Pathophysiology of lipid droplet proteins in liver diseases
Carr RM and Ahima RS. Exp Cell Res 2016 - Review. PMID 26515554 Free PMC article.
Evidence suggests that LD proteins are involved in the pathophysiology of fatty liver diseases characterized by excessive lipid accumulation in hepatocytes. ...
Evidence suggests that LD proteins are involved in the pathophysiology of fatty liver diseases characterized by excessive lipid accumulation …
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Xu M, et al. Hepatology 2016. PMID 26053944
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Feng D, et al. Hepatology 2016. PMID 25865955 Free PMC article.
Cell sources for in vitro human liver cell culture models
Zeilinger K, et al. Exp Biol Med (Maywood) 2016 - Review. PMID 27385595 Free PMC article.
Primary human hepatocytes (PHH) are currently considered to be the gold standard for hepatic in vitro culture models, since they directly reflect the specific metabolism and functionality of the human liver; however, the scarcity and difficult logistics of PHH have driven researchers to explore alternative cell sources, including liver cell lines and pluripotent stem cells. ...For the past few years, adult and pluripotent stem cells have been attracting increasing attention, due their ability to proliferate and to differentiate into hepatocyte-like cells in vitro However, controlling the differentiation of these cells is still a challenge. ...
Primary human hepatocytes (PHH) are currently considered to be the gold standard for hepatic in vitro culture models, since they dire …
[Study of the Metabolism of New Drugs of Abuse].
Kanamori T. Yakugaku Zasshi 2019 - Review. PMID 31061338 Japanese. Free article.
Thus, hepatocytes may be useful for predicting the in vivo metabolic fate of new drugs of abuse in humans. Recently, new types of human hepatocytes have been made commercially available for use in drug metabolism studies, such as a liver tumor-derived cell line (HepaRG), and a human induced pluripotent stem cell-derived hepatocyte (h-iPS-HEP). ...In addition, the phase I and II drug-metabolizing enzyme activities of HepaRG, h-iPS-HEP, liver-humanized mouse-derived hepatocytes (PXB-cellsTM), and human primary hepatocytes were evaluated and compared. ...
Thus, hepatocytes may be useful for predicting the in vivo metabolic fate of new drugs of abuse in humans. Recently, new types of hum …
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