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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1968 1
1977 1
1990 1
1992 2
1994 2
1995 1
1997 3
1998 1
1999 3
2000 51
2001 157
2002 179
2003 203
2004 202
2005 258
2006 285
2007 282
2008 283
2009 276
2010 311
2011 357
2012 370
2013 374
2014 445
2015 434
2016 405
2017 406
2018 425
2019 158
2020 7
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5,173 results
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Page 1
Non-Alcoholic Fatty Liver Disease
Engin A. Adv Exp Med Biol 2017 - Review. PMID 28585211
NAFLD is characterized by excess accumulation of triglyceride in the hepatocyte due to both increased inflow of free fatty acids and de novo hepatic lipogenesis. ...Furthermore, hepatocyte lipoapoptosis is a critical feature of NASH. In "second hit" reduced glutathione levels due to oxidative stress lead to overactivation of c-Jun N-terminal kinase (JNK)/c-Jun signaling that induces cell death in the steatotic liver. ...
NAFLD is characterized by excess accumulation of triglyceride in the hepatocyte due to both increased inflow of free fatty acids and …
Nonalcoholic Steatohepatitis
Suzuki A and Diehl AM. Annu Rev Med 2017 - Review. PMID 27732787
NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic steatosis). ...
NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic …
Pathology of non-alcoholic fatty liver disease.
Bedossa P. Liver Int 2017 - Review. PMID 28052629
When at least 5% of hepatocytes display steatosis, patients can be defined as having NAFLD in an appropriate clinical context. ...
When at least 5% of hepatocytes display steatosis, patients can be defined as having NAFLD in an appropriate clinical context. ...
Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation.
Ibrahim SH, et al. Gut 2018 - Review. PMID 29367207 Free PMC article.
In this review, we discuss the signalling pathways induced by sublethal hepatocyte lipid overload that contribute to the pathogenesis of NASH. ...We also review the potential therapeutic strategies to block the feed-forward loop between sublethal hepatocyte injury and liver inflammation....
In this review, we discuss the signalling pathways induced by sublethal hepatocyte lipid overload that contribute to the pathogenesis …
Structural and functional hepatocyte polarity and liver disease.
Gissen P and Arias IM. J Hepatol 2015 - Review. PMID 26116792 Free PMC article.
Establishment and maintenance of hepatocyte polarity is essential for many functions of hepatocytes and requires carefully orchestrated cooperation between cell adhesion molecules, cell junctions, cytoskeleton, extracellular matrix and intracellular trafficking machinery. ...Thus both structural and functional components contribute to the final hepatocyte polarity phenotype. Many acquired liver diseases target factors that determine hepatocyte polarity, such as junctional proteins. ...
Establishment and maintenance of hepatocyte polarity is essential for many functions of hepatocytes and requires carefully orc …
Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes.
Deng X, et al. Cell Stem Cell 2018. PMID 29937200 Free article.
Through lineage tracing of biliary epithelial cells (BECs), we show that BECs are a source of new hepatocytes and gain an Hnf4α(+)CK19(+) bi-phenotypic state in periportal regions and fibrotic septa. ...Together, these data provide further support for hepatocyte regeneration from BECs without genetic interventions and show their cellular plasticity during severe liver injury....
Through lineage tracing of biliary epithelial cells (BECs), we show that BECs are a source of new hepatocytes and gain an Hnf4α(+)CK1 …
Strategies for immortalization of primary hepatocytes.
Ramboer E, et al. J Hepatol 2014 - Review. PMID 24911463 Free PMC article.
Liver regeneration is hereby largely driven by hepatocyte proliferation, which in turn relies on cell cycling. The hepatocyte cell cycle is a complex process that is tightly regulated by several well-established mechanisms. In vitro, isolated hepatocytes do not longer retain this proliferative capacity. However, in vitro cell growth can be boosted by immortalization of hepatocytes. ...
Liver regeneration is hereby largely driven by hepatocyte proliferation, which in turn relies on cell cycling. The hepatocyte
Hepatocyte polyploidization and its association with pathophysiological processes.
Wang MJ, et al. Cell Death Dis 2017 - Review. PMID 28518148 Free PMC article.
Interestingly, the high prevalence of hepatocyte polyploidization in the aged mouse liver can be reversed when the senescent hepatocytes are serially transplanted into young mouse livers. Here we review the current knowledge on the mechanism of hepatocytes polyploidization during postnatal growth, aging, and liver diseases. ...
Interestingly, the high prevalence of hepatocyte polyploidization in the aged mouse liver can be reversed when the senescent hepat
Cell death and cell death responses in liver disease: mechanisms and clinical relevance
Luedde T, et al. Gastroenterology 2014 - Review. PMID 25046161 Free PMC article.
Clinical data and animal models suggest that hepatocyte death is the key trigger of liver disease progression, manifested by the subsequent development of inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma. ...
Clinical data and animal models suggest that hepatocyte death is the key trigger of liver disease progression, manifested by the subs …
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