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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1980 1
1981 2
1983 1
1992 2
1993 1
1994 2
1997 2
1998 2
1999 5
2000 166
2001 419
2002 434
2003 498
2004 515
2005 598
2006 559
2007 556
2008 552
2009 506
2010 522
2011 522
2012 578
2013 596
2014 654
2015 673
2016 593
2017 567
2018 529
2019 220
2020 5
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9,118 results
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Page 1
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.
Hu H, et al. Cell 2018. PMID 30500538 Free article.
Two modes of damage response have been described: (1) The "oval cell" response emanates from the biliary tree when all hepatocytes are affected by chronic liver disease. (2) A massive, proliferative response of mature hepatocytes occurs upon acute liver damage such as partial hepatectomy (PHx). ...Transcriptional profiles of the organoids resemble those of proliferating hepatocytes after PHx. Human hepatocyte organoids proliferate extensively after engraftment into mice and thus recapitulate the proliferative damage-response of hepatocytes....
Two modes of damage response have been described: (1) The "oval cell" response emanates from the biliary tree when all hepatocytes ar …
Hepatocyte polarity.
Treyer A and Müsch A. Compr Physiol 2013 - Review. PMID 23720287 Free PMC article.
Despite these universal principles, hepatocytes distinguish themselves from other nonstriated epithelia by their multipolar organization. Each hepatocyte participates in multiple, narrow lumina, the bile canaliculi, and has multiple basal surfaces that face the endothelial lining. ...
Despite these universal principles, hepatocytes distinguish themselves from other nonstriated epithelia by their multipolar organizat …
Hepatocyte polyploidization and its association with pathophysiological processes.
Wang MJ, et al. Cell Death Dis 2017 - Review. PMID 28518148 Free PMC article.
Interestingly, the high prevalence of hepatocyte polyploidization in the aged mouse liver can be reversed when the senescent hepatocytes are serially transplanted into young mouse livers. Here we review the current knowledge on the mechanism of hepatocytes polyploidization during postnatal growth, aging, and liver diseases. ...
Interestingly, the high prevalence of hepatocyte polyploidization in the aged mouse liver can be reversed when the senescent hepat
Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures.
Yokoyama Y, et al. Biol Pharm Bull 2018. PMID 29445054 Free article.
In this study, the feasibility of HepaRG cells as a human hepatocyte model for in vitro toxicity assessment was examined using selected hepatotoxic compounds. ...Enzyme activities in differentiated HepaRG cells were comparable to those in human hepatocytes and much higher than those in HepG2 cells, except for SULT activity. ...
In this study, the feasibility of HepaRG cells as a human hepatocyte model for in vitro toxicity assessment was examined using select …
Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes.
Katsuda T, et al. Elife 2019. PMID 31393263 Free PMC article.
Hepatocytes are regarded as the only effective cell source for cell transplantation to treat liver diseases; however, their availability is limited due to a donor shortage. ...We recently reported that mature rodent hepatocytes can be reprogrammed into progenitor-like cells with a repopulative capacity using small molecule inhibitors. ...
Hepatocytes are regarded as the only effective cell source for cell transplantation to treat liver diseases; however, their availabil
The interplay between hepatic stellate cells and hepatocytes in an in vitro model of NASH.
Barbero-Becerra VJ, et al. Toxicol In Vitro 2015. PMID 26187275
BACKGROUND & AIM: A complex interplay exists between hepatocytes and hepatic stellate cells (HSC) in hepatic fibrogenesis. The activation of HSCs after liver injury leads to production of extracellular matrix (ECM). ...This study evaluates the effect of free fatty acids (FFA) on HSC cells and the interplay with hepatocytes via both soluble-mediator and cell-cell contact. ...
BACKGROUND & AIM: A complex interplay exists between hepatocytes and hepatic stellate cells (HSC) in hepatic fibrogenesis. The ac …
Biomarkers of liver cell death
Eguchi A, et al. J Hepatol 2014 - Review. PMID 24412608 Free article.
Hepatocyte cell death during liver injury was classically viewed to occur by either programmed (apoptosis), or accidental, uncontrolled cell death (necrosis). ...Nevertheless, the realization that during cell demise triggered by a specific mode of cell death certain intracellular molecules such as proteins, newly generated protein fragments, or MicroRNAs are released from hepatocytes into the extracellular space and may appear in circulation have spurred a significant interest in the development of non-invasive markers to monitor liver cell death. ...
Hepatocyte cell death during liver injury was classically viewed to occur by either programmed (apoptosis), or accidental, uncontroll
Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes.
Akie TE and Cooper MP. J Vis Exp 2015. PMID 26382148 Free PMC article.
In the liver, hepatocytes regulate the breakdown and synthesis of fatty acids via β-fatty oxidation and de novo lipogenesis, respectively. ...Hence, quantifying β-fatty acid oxidation and de novo lipogenesis in cultured mouse hepatocytes provides a straight forward method to assess hepatocyte lipid handling. ...
In the liver, hepatocytes regulate the breakdown and synthesis of fatty acids via β-fatty oxidation and de novo lipogenesis, respecti …
[Study of the Metabolism of New Drugs of Abuse]
Kanamori T. Yakugaku Zasshi 2019 - Review. PMID 31061338 Japanese. Free article.
Thus, hepatocytes may be useful for predicting the in vivo metabolic fate of new drugs of abuse in humans. Recently, new types of human hepatocytes have been made commercially available for use in drug metabolism studies, such as a liver tumor-derived cell line (HepaRG), and a human induced pluripotent stem cell-derived hepatocyte (h-iPS-HEP). ...In addition, the phase I and II drug-metabolizing enzyme activities of HepaRG, h-iPS-HEP, liver-humanized mouse-derived hepatocytes (PXB-cellsTM), and human primary hepatocytes were evaluated and compared. ...
Thus, hepatocytes may be useful for predicting the in vivo metabolic fate of new drugs of abuse in humans. Recently, new types of hum …
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