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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1980 16
1981 39
1982 31
1983 42
1984 41
1985 73
1986 48
1987 36
1988 34
1989 39
1990 43
1991 54
1992 63
1993 73
1994 95
1995 121
1996 131
1997 139
1998 177
1999 182
2000 227
2001 211
2002 144
2003 156
2004 182
2005 217
2006 195
2007 220
2008 176
2009 45
2010 58
2011 65
2012 50
2013 74
2014 65
2015 56
2016 57
2017 51
2018 48
2019 31
2020 1
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3,643 results
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Page 1
High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX.
Singh I, et al. Cell Res 2015. PMID 26045162 Free PMC article.
However, chromatin also contains non-histone chromatin-associated proteins, of which the high-mobility group (HMG) proteins are the most abundant. Although it is known that HMG proteins induce structural changes of chromatin, the processes underlying transcription regulation by HMG proteins are poorly understood. ...
However, chromatin also contains non-histone chromatin-associated proteins, of which the high-mobility group (HM …
High mobility group (HMG) proteins: Modulators of chromatin structure and DNA repair in mammalian cells.
Reeves R. DNA Repair (Amst) 2015 - Review. PMID 26411874
It has been almost a decade since the last review appeared comparing and contrasting the influences that the different families of High Mobility Group proteins (HMGA, HMGB and HMGN) have on the various DNA repair pathways in mammalian cells. ...This review will focus on what is currently known about the roles that different HMG proteins play in DNA repair processes and discuss possible future research areas in this rapidly evolving field....
It has been almost a decade since the last review appeared comparing and contrasting the influences that the different families of High
High mobility group proteins.
Bustin M. Biochim Biophys Acta 2010. PMID 20123064
Binding of high mobility group A proteins to the mammalian genome occurs as a function of AT-content.
Colombo DF, et al. PLoS Genet 2017. PMID 29267285 Free PMC article.
Genomic location can inform on potential function and recruitment signals for chromatin-associated proteins. High mobility group (Hmg) proteins are of similar size as histones with Hmga1 and Hmga2 being particularly abundant in replicating normal tissues and in cancerous cells. ...Assessment of the underlying queues instructive for this binding modality identifies AT richness, defined as high frequency of A or T bases, as the major criterion for local binding. ...
Genomic location can inform on potential function and recruitment signals for chromatin-associated proteins. High mobility
TOX is a critical regulator of tumour-specific T cell differentiation
Scott AC, et al. Nature 2019. PMID 31207604
Conversely, deletion of Tox in TST cells in tumours abrogated the exhaustion program: Tox-deleted TST cells did not upregulate genes for inhibitory receptors (such as Pdcd1, Entpd1, Havcr2, Cd244 and Tigit), the chromatin of which remained largely inaccessible, and retained high expression of transcription factors such as TCF-1. ...
Conversely, deletion of Tox in TST cells in tumours abrogated the exhaustion program: Tox-deleted TST cells did not upregulate genes for inh …
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
Alfei F, et al. Nature 2019. PMID 31207605
Here we report that the development and maintenance of populations of exhausted T cells in mice requires the thymocyte selection-associated high mobility group box (TOX) protein(13-15). TOX is induced by high antigen stimulation of the T cell receptor and correlates with the presence of an exhausted phenotype during chronic infections with lymphocytic choriomeningitis virus in mice and hepatitis C virus in humans. ...
Here we report that the development and maintenance of populations of exhausted T cells in mice requires the thymocyte selection-associated …
High mobility group box transcription factor 1 (HBP1) from Lampetra japonica affects cell cycle regulation.
Song X, et al. Dev Growth Differ 2018. PMID 29520767
High mobility group (HMG) box-containing protein 1 (HBP1) is a member of the HMG family of chromosomal proteins. Previous studies have shown that human HBP1 exhibits tumor-suppressor activity. ...The L-hbp1 gene shared high sequence similarity with its homologues in jawed vertebrates, as shown by bioinformatics analyses. ...
High mobility group (HMG) box-containing protein 1 (HBP1) is a member of the HMG family of chromosomal proteins.
Enhanceosome transcription factors preferentially dimerize with high mobility group proteins.
Jankowski A, et al. BMC Syst Biol 2016. PMID 26847699 Free PMC article.
We also used 20 TRANSFAC motifs comprising not only the usual TFs constituting the enhanceosome but also the architectural proteins of High Mobility Group I(Y) (HMG I). ...NF- κB did not participate in forming dimers with other proteins. Dimers predicted in mouse were fully contained in those predicted in human, with exactly the same spacing and orientation. ...
We also used 20 TRANSFAC motifs comprising not only the usual TFs constituting the enhanceosome but also the architectural proteins o …
High mobility group protein DSP1 negatively regulates HSP70 transcription in Crassostrea hongkongensis.
Miao Z, et al. Biochem Biophys Res Commun 2016. PMID 27154224
HSP70 acts mostly as a molecular chaperone and plays important roles in facilitating the folding of nascent peptides as well as the refolding or degradation of the denatured proteins. ...In this study, a high mobility group protein DSP1 was identified by DNA-affinity purification from the nuclear extracts of Crassostrea hongkongensis using the ChHSP70 promoter as a bait. ...
HSP70 acts mostly as a molecular chaperone and plays important roles in facilitating the folding of nascent peptides as well as the refoldin …
Prognostic value of high mobility group protein A2 (HMGA2) over-expression in cancer progression.
Binabaj MM, et al. Gene 2019. PMID 31055021
The high mobility group A2 (HMGA2; also called HMGI-C) gene is an architectural transcription factor that belonging to the high mobility group AT-hook (HMGA) gene family. ...In subgroup analyses, high HMGA2 expression was particularly associated with poor OS in individuals with gastrointestinal (GI) cancer (HR = 1.89, 95% CI: 1.83-1.96; fixed-effect model) and HNSCC cancer (HR-1.78, 95%CI: 1.44-2.21; fixed-effect model). ...
The high mobility group A2 (HMGA2; also called HMGI-C) gene is an architectural transcription factor that belonging to …
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