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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 12
1985 52
1986 32
1987 26
1988 25
1989 31
1990 36
1991 49
1992 54
1993 65
1994 89
1995 106
1996 125
1997 129
1998 159
1999 173
2000 205
2001 226
2002 229
2003 258
2004 307
2005 425
2006 579
2007 715
2008 898
2009 1058
2010 1160
2011 1344
2012 1465
2013 1586
2014 1564
2015 1589
2016 1576
2017 1527
2018 1496
2019 652
2020 10
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17,763 results
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Page 1
The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.
Sumter TF, et al. Curr Mol Med 2016 - Review. PMID 26980699 Free PMC article.
Chromatin remodeling proteins regulate chromatin structure and high mobility group A (HMGA1) proteins are among the most abundant, nonhistone chromatin remodeling proteins found in cancer cells. These proteins include HMGA1a/HMGA1b isoforms, which result from alternatively spliced mRNA. The HMGA1 gene is overexpressed in cancer and high levels portend a poor prognosis in diverse tumors. ...
Chromatin remodeling proteins regulate chromatin structure and high mobility group A (HMGA1) proteins are …
HMGB1 in health and disease
Kang R, et al. Mol Aspects Med 2014 - Review. PMID 25010388 Free PMC article.
In 1973, a group of non-histone nuclear proteins with high electrophoretic mobility was discovered and termed high-mobility group (HMG) proteins. The HMG proteins include three superfamilies termed HMGB, HMGN, and HMGA. High-mobility group box 1 (HMGB1), the most abundant and well-studied HMG protein, senses and coordinates the cellular stress response and plays a critical role not only inside of the cell as a DNA chaperone, chromosome guardian, autophagy sustainer, and protector from apoptotic cell death, but also outside the cell as the prototypic damage associated molecular pattern molecule (DAMP). ...
In 1973, a group of non-histone nuclear proteins with high electrophoretic mobility was discovered and termed …
High-mobility group box 1 in Parkinson's disease: from pathogenesis to therapeutic approaches.
Angelopoulou E, et al. J Neurochem 2018 - Review. PMID 29676481 Free article.
Interestingly, recent evidence has indicated that High-mobility group box 1 (HMGB1), a DNA-binding protein that can be actively secreted by inflammatory cells and passively released by necrotic cells may play a key role in PD pathogenesis. ...
Interestingly, recent evidence has indicated that High-mobility group box 1 (HMGB1), a DNA-binding protein that can be …
High-mobility group box-1 in sterile inflammation.
Tsung A, et al. J Intern Med 2014 - Review. PMID 24935761 Free article.
High-mobility group box 1 (HMGB1) was originally defined as a ubiquitous nuclear protein, but it was later determined that the protein has different roles both inside and outside of cells. ...
High-mobility group box 1 (HMGB1) was originally defined as a ubiquitous nuclear protein, but it was later determined t
[Clinical application of high mobility group box nuclear protein 1 subcomponent in the progression of liver cancer].
Dong ZZ, et al. Zhonghua Gan Zang Bing Za Zhi 2018. PMID 30616326 Chinese.
The biological functions of high-mobility group (HMG) proteins include regulation of DNA replication, transcription, recombination and repair. According to molecular weight, sequence alignment and DNA structural characteristics, HMG proteins are subdivided into three superfamilies (HMGA, HMGB and HMGN). ...
The biological functions of high-mobility group (HMG) proteins include regulation of DNA replication, transcript …
Prognostic value of high mobility group protein A2 (HMGA2) over-expression in cancer progression.
Binabaj MM, et al. Gene 2019. PMID 31055021
The high mobility group A2 (HMGA2; also called HMGI-C) gene is an architectural transcription factor that belonging to the high mobility group AT-hook (HMGA) gene family. ...In subgroup analyses, high HMGA2 expression was particularly associated with poor OS in individuals with gastrointestinal (GI) cancer (HR = 1.89, 95% CI: 1.83-1.96; fixed-effect model) and HNSCC cancer (HR-1.78, 95%CI: 1.44-2.21; fixed-effect model). ...
The high mobility group A2 (HMGA2; also called HMGI-C) gene is an architectural transcription factor that belonging to …
Quantification of Serum High Mobility Group Box 1 by Liquid Chromatography/High-Resolution Mass Spectrometry: Implications for Its Role in Immunity, Inflammation, and Cancer.
Weng L, et al. Anal Chem 2018. PMID 29791130 Free PMC article.
High mobility group box 1 (HMGB1) is a non-histone chromosomal protein, which can be secreted through a variety of pathways and bind to pattern recognition receptors to release pro-inflammatory cytokines. ...To overcome these potential problems, we developed and validated a specific and sensitive assay based on stable isotope dilution and immunopurification to quantify HMGB1 in plasma and serum using two-dimensional nano-ultra-high-performance liquid chromatography parallel reaction monitoring/high-resolution mass spectrometry. ...
High mobility group box 1 (HMGB1) is a non-histone chromosomal protein, which can be secreted through a variety of path
HMGB proteins and arthritis.
Taniguchi N, et al. Hum Cell 2018 - Review. PMID 28916968 Free PMC article.
The high-mobility group box (HMGB) family includes four members: HMGB1, 2, 3 and 4. HMGB proteins have two functions. In the nucleus, HMGB proteins bind to DNA in a DNA structure-dependent but nucleotide sequence-independent manner to function in chromatin remodeling. ...The multiple functions of HMGB proteins reveal the complex roles of these proteins as innate and endogenous regulators of inflammation in joints and their cooperative roles in cartilage hypertrophy as well as in the maintenance of joint tissue homeostasis....
The high-mobility group box (HMGB) family includes four members: HMGB1, 2, 3 and 4. HMGB proteins have two funct …
High Expression of High-Mobility Group Box 1 in Menstrual Blood: Implications for Endometriosis.
Shimizu K, et al. Reprod Sci 2017. PMID 29017437 Free article.
To address this issue, the present study examined the expression of high-mobility group box (HMGB) 1 in menstrual blood to investigate its role in the ectopic growth of human endometriotic stromal cells (ESCs). ...These results suggest that menstrual fluid has naturally high levels of HMGB1 and may promote endometriosis following retrograde menstruation when complexed with other factors such as LPS by inducing inflammation and angiogenesis....
To address this issue, the present study examined the expression of high-mobility group box (HMGB) 1 in menstrual blood …
Role of high-mobility group box-1 protein in disruption of vascular barriers and regulation of leukocyte-endothelial interactions.
Nawaz MI and Mohammad G. J Recept Signal Transduct Res 2015 - Review. PMID 26482025
High-mobility group box-1 protein (HMGB1) is a highly conserved non-histone DNA-binding protein present in the nuclei and cytoplasm of nearly all cell types. ...Such process promotes the adhesion and migration of leukocytes across the endothelium, leading to breakdown of vascular barriers (blood-brain barrier and blood-retinal barrier) via modulating the expression, content, phosphorylation, and distribution of tight junction proteins. ...
High-mobility group box-1 protein (HMGB1) is a highly conserved non-histone DNA-binding protein present in the nuclei a
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