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Roles and regulations of Hippo signaling during preimplantation mouse development.
Sasaki H. Dev Growth Differ 2017 - Review. PMID 28035666
Recent studies have revealed that the intercellular Hippo signaling pathway plays a central role in the specification of the first cell fates. Hippo signaling is active in the inner cells but inactive in the outer cells. The Hippo-active inner and Hippo-inactive outer cells take the fates of the ICM and the TE, respectively. ...
Recent studies have revealed that the intercellular Hippo signaling pathway plays a central role in the specification of the first ce …
Visualizing HIPPO Signaling Components in Mouse Early Embryonic Development.
Frum T and Ralston A. Methods Mol Biol 2019. PMID 30565145
The HIPPO signaling pathway plays an early and essential role in mammalian embryogenesis. The earliest known roles for HIPPO signaling during mouse development include segregating fetal and extraembryonic lineages and establishing the pluripotent progenitors of embryonic stem (ES) cells. ...Here, we share approaches for visualizing HIPPO signaling in mouse early embryos. In addition, these methods can be applied to visualize HIPPO signaling in other spherical or cystic structures comprised of relatively few cells, such as organoids, or for the examination of other signaling pathways in these contexts....
The HIPPO signaling pathway plays an early and essential role in mammalian embryogenesis. The earliest known roles for HIPPO s …
Hippo signaling in the kidney: the good and the bad.
Wong JS, et al. Am J Physiol Renal Physiol 2016 - Review. PMID 27194720 Free PMC article.
At the center of this network lie the Hippo kinase target and downstream pathway effector Yes-associated protein (YAP) and its paralog TAZ. ...This review summarizes the current knowledge of the Hippo-YAP signaling axis in the kidney under normal and disease conditions....
At the center of this network lie the Hippo kinase target and downstream pathway effector Yes-associated protein (YAP) and its …
Hippo pathway deficiency reverses systolic heart failure after infarction.
Leach JP, et al. Nature 2017. PMID 28976966 Free PMC article.
The Hippo pathway, a kinase cascade that prevents adult cardiomyocyte proliferation and regeneration, is upregulated in human heart failure. ...Hippo-deficient cardiomyocytes have increased expression of proliferative genes and stress response genes, such as the mitochondrial quality control gene, Park2. ...
The Hippo pathway, a kinase cascade that prevents adult cardiomyocyte proliferation and regeneration, is upregulated in human heart f …
Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo.
Posfai E, et al. Elife 2017. PMID 28226240 Free PMC article.
The segregation of the trophectoderm (TE) from the inner cell mass (ICM) in the mouse blastocyst is determined by position-dependent Hippo signaling. ...Plasticity of both lineages is coincident with their window of sensitivity to Hippo signaling....
The segregation of the trophectoderm (TE) from the inner cell mass (ICM) in the mouse blastocyst is determined by position-dependent Hipp
Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury
Tao G, et al. Nature 2016. PMID 27251288 Free PMC article.
By testing an established Hippo-deficient heart regeneration mouse model for factors that promote renewal, here we show that the expression of Pitx2 is induced in injured, Hippo-deficient ventricles. ...A subset of Pitx2 target genes was cooperatively regulated with the Hippo pathway effector Yap. Furthermore, Nrf2, a regulator of the antioxidant response, directly regulated the expression and subcellular localization of Pitx2. ...
By testing an established Hippo-deficient heart regeneration mouse model for factors that promote renewal, here we show that the expr …
Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation
Morikawa Y, et al. Nature 2017. PMID 28581498 Free PMC article.
The Yap-Dag1 interaction was enhanced by Hippo-induced Yap phosphorylation, revealing a connection between Hippo pathway function and the DGC. ...In the hearts of mature Mdx mice (which have a point mutation in Dmd)-a model of Duchenne muscular dystrophy-Hippo deficiency protected against overload-induced heart failure....
The Yap-Dag1 interaction was enhanced by Hippo-induced Yap phosphorylation, revealing a connection between Hippo pathway funct …
Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma.
Kim W, et al. Gut 2018. PMID 28866620 Free PMC article.
Hippo kinase (Mst1 and Mst2) inhibits HCC proliferation by suppressing Yap/Taz transcription activities. As human HCC is mainly driven by chronic liver inflammation, it is not clear whether Hippo signalling inhibits HCC by shaping its inflammatory microenvironment. ...CONCLUSIONS: Hippo signalling in hepatocytes maintains normal liver growth by suppressing macrophage infiltration during protumoural microenvironment formation through the inhibition of Yap-dependent Mcp1 expression, providing new targets and strategies to treat HCCs....
Hippo kinase (Mst1 and Mst2) inhibits HCC proliferation by suppressing Yap/Taz transcription activities. As human HCC is mainly drive
Hippo/Mst signalling couples metabolic state and immune function of CD8α(+) dendritic cells.
Du X, et al. Nature 2018. PMID 29849151 Free PMC article.
Our NetBID analysis reveals a marked enrichment of the activities of Hippo pathway kinases in CD8α(+) dendritic cells relative to CD8α(-) dendritic cells. ...Mst1/2-deficient CD8α(+) dendritic cells are impaired in presentation of extracellular proteins and cognate peptides to prime CD8(+) T cells, while CD8α(-) dendritic cells that lack Mst1/2 have largely normal function. ...
Our NetBID analysis reveals a marked enrichment of the activities of Hippo pathway kinases in CD8α(+) dendritic cells relative to CD8 …
Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development.
Xiao Y, et al. Dev Cell 2018. PMID 29689192 Free PMC article.
The Hippo pathway, a kinase cascade that inhibits the Yap transcriptional co-factor, controls organ size in developing hearts. ...Lats1/2 mutant cells displayed an arrested developmental trajectory with persistence of epicardial markers and expanded expression of Yap targets Dhrs3, an inhibitor of retinoic acid synthesis, and Dpp4, a protease that modulates extracellular matrix (ECM) composition. ...
The Hippo pathway, a kinase cascade that inhibits the Yap transcriptional co-factor, controls organ size in developing hearts. ...Lat …
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