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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1965 3
1966 7
1967 4
1968 4
1969 12
1970 10
1971 10
1972 21
1973 22
1974 33
1975 27
1976 24
1977 35
1978 34
1979 54
1980 59
1981 70
1982 72
1983 85
1984 94
1985 87
1986 123
1987 158
1988 176
1989 273
1990 255
1991 244
1992 314
1993 403
1994 476
1995 349
1996 373
1997 401
1998 405
1999 399
2000 507
2001 531
2002 604
2003 595
2004 580
2005 629
2006 678
2007 738
2008 721
2009 665
2010 855
2011 866
2012 926
2013 952
2014 896
2015 1032
2016 997
2017 994
2018 871
2019 325
2020 0
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18,160 results
Results by year
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Page 1
Blood-brain barrier breakdown in the aging human hippocampus.
Montagne A, et al. Neuron 2015. PMID 25611508 Free PMC article.
The BBB breakdown in the hippocampus and its CA1 and dentate gyrus subdivisions worsened with mild cognitive impairment that correlated with injury to BBB-associated pericytes, as shown by the cerebrospinal fluid analysis. Our data suggest that BBB breakdown is an early event in the aging human brain that begins in the hippocampus and may contribute to cognitive impairment....
The BBB breakdown in the hippocampus and its CA1 and dentate gyrus subdivisions worsened with mild cognitive impairment that correlat …
Dissociable Structural and Functional Hippocampal Outputs via Distinct Subiculum Cell Classes
Cembrowski MS, et al. Cell 2018. PMID 29681453 Free article.
The mammalian hippocampus, comprised of serially connected subfields, participates in diverse behavioral and cognitive functions. ...We sought to identify, delineate, and manipulate this putatively parallel architecture in the dorsal subiculum, the primary output subfield of the dorsal hippocampus. ...
The mammalian hippocampus, comprised of serially connected subfields, participates in diverse behavioral and cognitive functions. ... …
Distinct Proteomic, Transcriptomic, and Epigenetic Stress Responses in Dorsal and Ventral Hippocampus.
Floriou-Servou A, et al. Biol Psychiatry 2018. PMID 29605177 Free article.
Although the intrinsic organization of the hippocampus is highly conserved throughout its long dorsal-ventral axis, the dorsal (anterior) hippocampus mediates spatial navigation and memory formation, whereas the ventral (posterior) hippocampus is involved in emotion regulation. ...Selective Kdm6b knockdown in the ventral hippocampus led to behavioral hyperactivity/hyperresponsiveness. CONCLUSIONS: These findings underscore the importance of considering dorsal and ventral hippocampus separately when conducting high-throughput molecular analyses, which has important implications for fundamental research as well as clinical studies....
Although the intrinsic organization of the hippocampus is highly conserved throughout its long dorsal-ventral axis, the dorsal (anter …
In Situ Transcription Profiling of Single Cells Reveals Spatial Organization of Cells in the Mouse Hippocampus.
Shah S, et al. Neuron 2016. PMID 27764670 Free PMC article.
Using an in situ 3D multiplexed imaging method, seqFISH, we identify unique transcriptional states by quantifying and clustering up to 249 genes in 16,958 cells to examine whether the hippocampus is organized into transcriptionally distinct subregions. ...
Using an in situ 3D multiplexed imaging method, seqFISH, we identify unique transcriptional states by quantifying and clustering up to 249 g …
Cellular and Molecular Differences Between Area CA1 and the Dentate Gyrus of the Hippocampus.
Alkadhi KA. Mol Neurobiol 2019 - Review. PMID 30874972
A distinct feature of the hippocampus of the brain is its unidirectional tri-synaptic pathway originating from the entorhinal cortex and projecting to the dentate gyrus (DG) then to area CA3 and subsequently, area CA1 of the Ammon's horn. Each of these areas of the hippocampus has its own cellular structure and distinctive function. The principal neurons in these areas are granule cells in the DG and pyramidal cells in the Ammon's horn's CA1 and CA3 areas with a vast network of interneurons. ...
A distinct feature of the hippocampus of the brain is its unidirectional tri-synaptic pathway originating from the entorhinal cortex …
Integrated Metabolomics and Proteomics Analysis of Hippocampus in a Rat Model of Depression.
Zhang Y, et al. Neuroscience 2018. PMID 29237567
In this study, we applied an integrated analysis of gas chromatography/mass spectrometry (GC-MS)-based metabolomics and isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics to investigate changes in the hippocampus in the chronic unpredictable mild stress (CUMS) rat model of depression. ...The integrated analyses revealed four major changes in the hippocampus of CUMS rats: (1) impairment in amino acid metabolism and protein synthesis/degradation; (2) dysregulation of glutamate and glycine metabolism and their transport/catabolism related proteins; (3) disturbances in fatty acid and glycerophospholipid metabolism accompanied by alterations in the corresponding metabolic enzymes; (4) abnormal expression of synapse-associated proteins. ...
In this study, we applied an integrated analysis of gas chromatography/mass spectrometry (GC-MS)-based metabolomics and isobaric tags for re …
In Vivo Imaging of Dentate Gyrus Mossy Cells in Behaving Mice
Danielson NB, et al. Neuron 2017. PMID 28132825 Free PMC article.
Mossy cells in the hilus of the dentate gyrus constitute a major excitatory principal cell type in the mammalian hippocampus; however, it remains unknown how these cells behave in vivo. ...
Mossy cells in the hilus of the dentate gyrus constitute a major excitatory principal cell type in the mammalian hippocampus; however …
18,160 results
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