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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 2
1976 33
1977 95
1978 73
1979 75
1980 108
1981 154
1982 138
1983 167
1984 147
1985 201
1986 184
1987 236
1988 255
1989 248
1990 227
1991 223
1992 189
1993 180
1994 188
1995 254
1996 325
1997 302
1998 285
1999 226
2000 208
2001 169
2002 209
2003 184
2004 162
2005 197
2006 170
2007 151
2008 144
2009 156
2010 153
2011 128
2012 124
2013 128
2014 134
2015 106
2016 113
2017 114
2018 87
2019 28
2020 3
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7,188 results
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Page 1
Stress Ulcer Prophylaxis
Barletta JF, et al. Crit Care Med 2016 - Review. PMID 27163192
DATA SYNTHESIS: The existing evidence is organized to describe the patients most likely to benefit from stress ulcer prophylaxis, review the comparative efficacy of proton pump inhibitors and histamine 2 receptor antagonists, the adverse effects of stress ulcer prophylaxis, and overall cost-effectiveness. ...When evaluating only the trials at low risk for bias, the evidence does not clearly support lower bleeding rates with proton pump inhibitors over histamine 2 receptor antagonists; however, proton pump inhibitors appear to be the dominant drug class used worldwide today. ...
DATA SYNTHESIS: The existing evidence is organized to describe the patients most likely to benefit from stress ulcer prophylaxis, review the …
Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B-12 Deficiency: Clinical Implications.
Miller JW. Adv Nutr 2018 - Review. PMID 30032223 Free PMC article.
There is clear evidence that proton-pump inhibitors (PPIs), H2-receptor antagonists (H2RAs), and metformin can reduce serum vitamin B-12 concentrations by inhibiting the absorption of the vitamin. ...
There is clear evidence that proton-pump inhibitors (PPIs), H2-receptor antagonists (H2RAs), and metformin can reduce serum vi …
Cardioprotective effect of histamine H2 antagonists in congestive heart failure: A systematic review and meta-analysis.
Zhang J, et al. Medicine (Baltimore) 2018 - Review. PMID 29642208 Free PMC article.
BACKGROUND: Histamine H2 antagonists (H2RAs) have long been suggested to have beneficial effects on congestive heart failure (CHF). ...
BACKGROUND: Histamine H2 antagonists (H2RAs) have long been suggested to have beneficial effects on congestive heart fa …
Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units
Toews I, et al. Cochrane Database Syst Rev 2018 - Review. PMID 29862492 Free PMC article.
When taking H2 receptor antagonists, 4.8% more patients might experience upper GI bleeding (95% CI 2.1% to 9%). Nosocomial pneumonia occurred in similar proportions of participants taking H2 receptor antagonists and participants taking proton pump inhibitors (RR 1.02, 95% CI 0.77 to 1.35; 10 studies; 1256 participants; low certainty of evidence). ...Evidence of low certainty suggests that proton pump inhibitors might be more effective than H2 receptor antagonists. Therefore, patient-relevant benefits and especially harms of H2 receptor antagonists compared with proton pump inhibitors need to be assessed by larger, high-quality RCTs to confirm the results of previously conducted, smaller, and older studies....
When taking H2 receptor antagonists, 4.8% more patients might experience upper GI bleeding (95% CI 2.1% to 9%). Nosocomial pne …
Histamine H2 antagonists for functional dyspepsia: A protocol for a systematic review and meta-analysis.
Li J, et al. Medicine (Baltimore) 2019. PMID 31764854 Free PMC article.
Histamine H2 antagonists (H2RAs) are the pharmacological treatment option for FD, but no potent evidence has been found for the efficacy of these drugs in the condition. ...
Histamine H2 antagonists (H2RAs) are the pharmacological treatment option for FD, but no potent evidence has been found
Histamine-2 Receptor Antagonists and Semen Quality.
Banihani SA. Basic Clin Pharmacol Toxicol 2016 - Review. PMID 26176290 Free article.
Histamine-2 receptor antagonists are a class of drugs used to treat the acid-related gastrointestinal diseases such as ulcer and gastro-oesophageal reflux disease. ...Therefore, additional studies will be required to clarify whether histamine-2 receptor-independent effects of these drugs play a role in semen quality as well as further clinical studies including direct comparison of the histamine-2 receptor antagonists....
Histamine-2 receptor antagonists are a class of drugs used to treat the acid-related gastrointestinal diseases such as ulcer a
Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2(-/-) mice and human cholangiocarcinoma tumorigenesis.
Kennedy L, et al. Hepatology 2018. PMID 29601088 Free PMC article.
We have shown that (1) histamine increases biliary hyperplasia through H1/H2 histamine receptors (HRs) and (2) histamine levels increase and mast cells (MCs) infiltrate during PSC and CCA. ...H1/H2HR antagonists decreased tumor growth, serum histamine, angiogenesis, and EMT. In vitro, H1/H2HR blockers reduced biliary proliferation, and CCA cells had decreased proliferation, angiogenesis, EMT, and migration. ...
We have shown that (1) histamine increases biliary hyperplasia through H1/H2 histamine receptors (HRs) and (2) hista
ANTISECRETORY TREATMENT FOR PEDIATRIC GASTROESOPHAGEAL REFLUX DISEASE - A SYSTEMATIC REVIEW
Mattos ÂZ, et al. Arq Gastroenterol 2017 - Review. PMID 28954042 Free article.
BACKGROUND: Proton pump inhibitors and histamine H2 receptor antagonists are two of the most commonly prescribed drug classes for pediatric gastroesophageal reflux disease, but their efficacy is controversial. ...OBJECTIVE: To evaluate the use of proton pump inhibitors and histamine H2 receptor antagonists in pediatric gastroesophageal reflux disease through a systematic review. ...
BACKGROUND: Proton pump inhibitors and histamine H2 receptor antagonists are two of the most commonly prescribed drug c …
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