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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1976 12
1977 57
1978 26
1979 19
1980 34
1981 70
1982 52
1983 79
1984 60
1985 109
1986 91
1987 130
1988 146
1989 163
1990 139
1991 158
1992 122
1993 112
1994 110
1995 161
1996 207
1997 194
1998 182
1999 158
2000 137
2001 115
2002 143
2003 126
2004 120
2005 148
2006 116
2007 111
2008 92
2009 118
2010 110
2011 94
2012 91
2013 105
2014 105
2015 82
2016 90
2017 90
2018 73
2019 21
2020 0
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4,547 results
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Page 1
ANTISECRETORY TREATMENT FOR PEDIATRIC GASTROESOPHAGEAL REFLUX DISEASE - A SYSTEMATIC REVIEW
Mattos ÂZ, et al. Arq Gastroenterol 2017 - Review. PMID 28954042 Free article.
BACKGROUND: Proton pump inhibitors and histamine H2 receptor antagonists are two of the most commonly prescribed drug classes for pediatric gastroesophageal reflux disease, but their efficacy is controversial. ...OBJECTIVE: To evaluate the use of proton pump inhibitors and histamine H2 receptor antagonists in pediatric gastroesophageal reflux disease through a systematic review. ...
BACKGROUND: Proton pump inhibitors and histamine H2 receptor antagonists are two of the most commonly prescribed drug c …
Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review.
Cohen S, et al. Br J Clin Pharmacol 2015 - Review. PMID 25752807 Free PMC article.
Adverse effects have been reported in at least 23% of patients treated with histamine H2 receptor antagonists (H2 RAs) and 34% of those treated with proton pump inhibitors (PPIs), and mostly include headaches, diarrhoea, nausea (H2 RAs and PPIs) and constipation (PPIs). ...Prokinetic agents have many adverse effects, without major benefits to support their routine use....
Adverse effects have been reported in at least 23% of patients treated with histamine H2 receptor antagonists (H2
Histamine H2 antagonists for functional dyspepsia: A protocol for a systematic review and meta-analysis.
Li J, et al. Medicine (Baltimore) 2019. PMID 31764854 Free PMC article.
Histamine H2 antagonists (H2RAs) are the pharmacological treatment option for FD, but no potent evidence has been found for the efficacy of these drugs in the condition. ...
Histamine H2 antagonists (H2RAs) are the pharmacological treatment option for FD, but no potent evidence has been found
Early Acid Suppression Therapy Exposure and Fracture in Young Children
Malchodi L, et al. Pediatrics 2019. PMID 31175146
BACKGROUND: Acid suppression therapy (AST), including proton pump inhibitors (PPIs) and histamine H(2)-receptor antagonists (H(2)RAs), is frequently prescribed to treat symptomatic gastroesophageal reflux in otherwise healthy infants. ...After adjustment, increased fracture hazard was associated with PPI use (21%) and PPI and H(2)RA use (30%), but not H(2)RA use alone. ...
BACKGROUND: Acid suppression therapy (AST), including proton pump inhibitors (PPIs) and histamine H(2)-receptor antagonists (H …
Proton pump inhibitors (PPIs) may cause gastric cancer - clinical consequences
Waldum HL, et al. Scand J Gastroenterol 2018 - Review. PMID 29852782
Gastro-oesophageal reflux disease (GERD) is the most prevalent condition leading to long-term use of inhibitors of gastric acid secretion. ...Finally, due to latency of neoplasia, the use of PPI must be very restricted in children and young adults....
Gastro-oesophageal reflux disease (GERD) is the most prevalent condition leading to long-term use of inhibitors of gastric acid secre …
Histamine H2-receptor antagonists.
Keithley JK. Nurs Clin North Am 1991 - Review. PMID 1675461
In summary, histamine initiates acid secretion by stimulating the H2 subtype histamine receptor on parietal cells. Cimetidine, rantidine, famotidine, and nizantidine are histamine H2-receptor antagonists that block this action of histamine, reducing gastric acid output and concentration under both basal and stimulated conditions. ...Because of their effectiveness and low incidence of side effects, H2-antagonists have largely replaced more traditional antiulcer regimens....
In summary, histamine initiates acid secretion by stimulating the H2 subtype histamine receptor on parietal cells. Cime …
What are the differences between the H2-receptor antagonists?
Schunack W. Aliment Pharmacol Ther 1987 - Review. PMID 2908767
Cimetidine, ranitidine and famotidine are competitive antagonists, while the long-acting H2-receptor antagonists, e.g. loxtidine and lamitidine, are insurmountable H2-receptor blockers. ...The overall number of side-effects of the H2-receptor antagonists is in the range of 2-3% and no irreversible adverse effects are known. ...
Cimetidine, ranitidine and famotidine are competitive antagonists, while the long-acting H2-receptor antagonists, e.g. …
Histamine H2-receptor antagonists in peptic ulcer disease. Efficacy in healing peptic ulcers.
Deakin M and Williams JG. Drugs 1992 - Review. PMID 1280563
Currently marketed doses of the histamine H2-receptor antagonists heal between 77 and 92% of duodenal ulcers at 4 weeks, and adjuvant treatment to eradicate Helicobacter pylori increases this rate. ...It is unlikely that the prostaglandin analogues can improve on the efficacy of the H2-receptor antagonists with as low an incidence of side effects....
Currently marketed doses of the histamine H2-receptor antagonists heal between 77 and 92% of duodenal ulcers at 4 weeks …
Histamine-2 Receptor Antagonists and Semen Quality.
Banihani SA. Basic Clin Pharmacol Toxicol 2016 - Review. PMID 26176290 Free article.
Histamine-2 receptor antagonists are a class of drugs used to treat the acid-related gastrointestinal diseases such as ulcer and gastro-oesophageal reflux disease. ...Therefore, additional studies will be required to clarify whether histamine-2 receptor-independent effects of these drugs play a role in semen quality as well as further clinical studies including direct comparison of the histamine-2 receptor antagonists....
Histamine-2 receptor antagonists are a class of drugs used to treat the acid-related gastrointestinal diseases such as ulcer a
Proton Pump Inhibitor and Histamine-2 Receptor Antagonist Use and Iron Deficiency.
Lam JR, et al. Gastroenterology 2017. PMID 27890768
BACKGROUND & AIMS: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) suppress gastric acid production, which can inhibit iron absorption. ...METHODS: A community-based case-control study evaluated the association between acid-suppressing medication use and the subsequent risk of iron deficiency. ...
BACKGROUND & AIMS: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) suppress gastric acid produc …
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