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2025 94
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A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy.
Croce KR, Ng C, Pankiv S, Albarran E, Langfelder P, Ramos de Jesus A, Duncan GM, Wang N, Basile A, McHugh C, Litt NA, Li A, Friedman S, Cortes EP, Zody MC, Yang XW, Ding JB, Vonsattel JPG, Simonsen A, Housman DE, Wexler NS, Yamamoto A. Croce KR, et al. Neuron. 2025 Nov 19;113(22):3780-3797.e7. doi: 10.1016/j.neuron.2025.08.018. Epub 2025 Sep 12. Neuron. 2025. PMID: 40945514 Free PMC article.
Pridopidine in early-stage manifest Huntington's disease: a phase 3 trial.
Reilmann R, Feigin A, Rosser AE, Kostyk SK, Saft C, Cohen Y, Schuring H, Hand R, Tan AM, Chen K, Feng W, Navon-Perry L, Cruz-Herranz A, Syltevik C, Boot D, Squitieri F, Kayson E, Mehra M, Goldberg YP, Geva M, Hayden MR; PROOF-HD study investigators. Reilmann R, et al. Nat Med. 2025 Nov;31(11):3780-3789. doi: 10.1038/s41591-025-03920-3. Epub 2025 Sep 5. Nat Med. 2025. PMID: 40913168 Free PMC article. Clinical Trial.
Cell-specific mechanisms drive connectivity across the time course of Huntington's disease.
Estevez-Fraga C, Sebenius I, Hansen JY, Hänisch B, Zeun P, Scahill RI, Gregory S, Johnson EB, Wild EJ, Byrne LM, Durr A, Landwehrmeyer B, Leavitt BR, Misic B, Valk SL, Rees G, Tabrizi SJ, McColgan P. Estevez-Fraga C, et al. Nat Commun. 2025 Jul 1;16(1):5519. doi: 10.1038/s41467-025-60556-0. Nat Commun. 2025. PMID: 40595490 Free PMC article.
Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.
Mathews EW, Coffey SR, Gärtner A, Belgrad J, Bragg RM, O'Reilly D, Cantle JP, McHugh C, Summers A, Fentz J, Schwagarus T, Cornelius A, Lingos I, Burch Z, Kovalenko M, Andrew MA, Bennett CF, Kordasiewicz HB, Marchionini DM, Wilkinson H, Vogt TF, Beuzer P, Pinto RM, Khvorova A, Howland D, Wheeler VC, Carroll JB. Mathews EW, et al. Nat Commun. 2025 Nov 14;16(1):10009. doi: 10.1038/s41467-025-64936-4. Nat Commun. 2025. PMID: 41238535 Free PMC article.
140 results