Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 1
1958 1
1965 1
1966 3
1967 2
1968 1
1969 5
1970 2
1971 3
1972 10
1973 4
1974 8
1975 5
1976 9
1977 6
1978 8
1979 8
1980 12
1981 11
1982 10
1983 22
1984 20
1985 25
1986 29
1987 23
1988 21
1989 48
1990 31
1991 32
1992 57
1993 87
1994 62
1995 76
1996 67
1997 69
1998 43
1999 72
2000 63
2001 62
2002 59
2003 55
2004 60
2005 66
2006 73
2007 89
2008 88
2009 77
2010 87
2011 93
2012 107
2013 121
2014 96
2015 114
2016 110
2017 109
2018 97
2019 23
2020 0
Text availability
Article attribute
Article type
Publication date

Search Results

2,354 results
Results by year
Filters applied: . Clear all
Page 1
Genetics of Huntington disease.
Nance MA. Handb Clin Neurol 2017 - Review. PMID 28947123
Important aspects of the clinical genetics and epidemiology of Huntington's disease are discussed, such as the definition of "normal" and "abnormal" numbers of CAG (cytosine-adenine-guanine) repeats in the critical spot within the huntingtin gene, meiotic instability of CAG repeat numbers, common Huntington's disease genetic haplotypes, compound heterozygosity for an abnormal gene, and somatic mosaicism for CAG repeat expansions. We touch only briefly on the creation of multiple animal models for Huntington's disease that have profoundly impacted our understanding of the disease and permitted the development of potential disease-modifying treatments, and end with what is, at the time of writing, the dawn of a new era: the advent of gene-based therapies (gene silencing, gene editing) for Huntington's disease....
Important aspects of the clinical genetics and epidemiology of Huntington's disease are discussed, such as the definition of "normal" …
Huntington disease.
Bates GP, et al. Nat Rev Dis Primers 2015 - Review. PMID 27188817
Huntington disease is devastating to patients and their families - with autosomal dominant inheritance, onset typically in the prime of adult life, progressive course, and a combination of motor, cognitive and behavioural features. ...In this Primer, we review the epidemiology of Huntington disease, noting that prevalence is higher than previously thought, geographically variable and increasing. ...
Huntington disease is devastating to patients and their families - with autosomal dominant inheritance, onset typically in the prime
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.
[No authors listed] Cell 1993. PMID 8458085
The Huntington's disease (HD) gene has been mapped in 4p16.3 but has eluded identification. We have used haplotype analysis of linkage disequilibrium to spotlight a small segment of 4p16.3 as the likely location of the defect. ...
The Huntington's disease (HD) gene has been mapped in 4p16.3 but has eluded identification. We have used haplotype analysis of linkag …
Preimplantation genetics and other reproductive options in Huntington disease.
Blancato JK, et al. Handb Clin Neurol 2017 - Review. PMID 28947109 Free PMC article.
Preimplantation genetic diagnosis (PGD) is a form of prenatal diagnosis applied to potential parents with known carrier status of a genetic disease, such as Huntington disease. ...PGD allows the couple the chance to have a pregnancy and livebirth child without Huntington disease, although there are some risks and expenses related to the procedures. ...
Preimplantation genetic diagnosis (PGD) is a form of prenatal diagnosis applied to potential parents with known carrier status of a genetic …
Genetic modifiers of Mendelian disease: Huntington's disease and the trinucleotide repeat disorders.
Holmans PA, et al. Hum Mol Genet 2017 - Review. PMID 28977442
In Huntington's disease (HD), caused by an expanded CAG repeat tract in HTT, genetic variation has been uncovered that is associated with change in the onset or progression of disease. ...
In Huntington's disease (HD), caused by an expanded CAG repeat tract in HTT, genetic variation has been uncovered that is associated …
Identification of Genetic Factors that Modify Clinical Onset of Huntington's Disease.
Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium . Cell 2015. PMID 26232222 Free PMC article.
As a Mendelian neurodegenerative disorder, the genetic risk of Huntington's disease (HD) is conferred entirely by an HTT CAG repeat expansion whose length is the primary determinant of the rate of pathogenesis leading to disease onset. ...
As a Mendelian neurodegenerative disorder, the genetic risk of Huntington's disease (HD) is conferred entirely by an HTT CAG repeat e …
Huntington Disease: A Disease of DNA Methylation or DNA Breaks?
Ferlazzo ML and Foray N. Am J Pathol 2016. PMID 27219493 Free article.
This commentary highlights the article by Mollica et al that describes an interesting model for the clinical evolution of Huntington disease....
This commentary highlights the article by Mollica et al that describes an interesting model for the clinical evolution of Huntington
The views of adults with Huntington's disease on assisted dying: A qualitative exploration.
Regan L, et al. Palliat Med 2018. PMID 29139332
SETTING/PARTICIPANTS: Seven participants (five women and two men) who were gene positive for Huntington's disease took part in the study. ...CONCLUSIONS: Our findings suggest that talking to patients about assisted death may not cause harm and may even be invited by many patients with Huntington's disease. ...
SETTING/PARTICIPANTS: Seven participants (five women and two men) who were gene positive for Huntington's disease took part in the st …
Huntington Disease: Linking Pathogenesis to the Development of Experimental Therapeutics.
Mestre TA and Sampaio C. Curr Neurol Neurosci Rep 2017 - Review. PMID 28265888
Huntington disease (HD) is an autosomal dominant neurodegenerative condition caused by a CAG trinucleotide expansion in the huntingtin gene. ...
Huntington disease (HD) is an autosomal dominant neurodegenerative condition caused by a CAG trinucleotide expansion in the huntingti
2,354 results
Jump to page
Feedback