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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 1
1957 1
1958 2
1961 1
1963 1
1964 2
1965 2
1966 1
1969 11
1970 4
1971 58
1972 126
1973 153
1974 219
1975 276
1976 302
1977 216
1978 336
1979 334
1980 514
1981 619
1982 802
1983 898
1984 855
1985 883
1986 862
1987 812
1988 867
1989 919
1990 1014
1991 986
1992 1094
1993 1050
1994 958
1995 921
1996 706
1997 621
1998 605
1999 613
2000 533
2001 452
2002 358
2003 398
2004 305
2005 370
2006 324
2007 300
2008 278
2009 245
2010 234
2011 242
2012 237
2013 214
2014 172
2015 176
2016 125
2017 148
2018 111
2019 54
2020 0
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23,587 results
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Page 1
Cell Fusion in Human Cancer: The Dark Matter Hypothesis.
Weiler J and Dittmar T. Cells 2019 - Review. PMID 30736482 Free PMC article.
By doing so, several studies have demonstrated that TN-hybrid cells could be found in human cancers. However, a prerequisite of this cell fusion search strategy is that such markers are stably expressed by TN-hybrid cells over time. However, cell fusion is a potent inducer of genomic instability, and TN-hybrid cells may lose these cell fusion markers, thereby becoming indistinguishable from nonfused tumor cells. ...
By doing so, several studies have demonstrated that TN-hybrid cells could be found in human cancers. However, a prerequisite o …
Embryonic hybrid cells: a powerful tool for studying pluripotency and reprogramming of the differentiated cell chromosomes.
Serov O, et al. An Acad Bras Cienc 2001 - Review. PMID 11743603 Free article.
The properties of embryonic hybrid cells obtained by fusion of embryonic stem (ES) or teratocarcinoma (TC) cells with differentiated cells are reviewed. ...When cultured in vitro, ES-somatic- and TC-somatic hybrid cell clones, as a rule, lose the chromosomes derived from the somatic partner; however, in some clones the autosomes from the ES cell partner were also eliminated, i.e. the parental chromosomes segregated bilaterally in the ES-somatic cell hybrids. ...
The properties of embryonic hybrid cells obtained by fusion of embryonic stem (ES) or teratocarcinoma (TC) cells with d …
The influence of reference radiation photon energy on high-LET RBE: comparison of human peripheral lymphocytes and human-hamster hybrid A(L) cells.
Schmid TE, et al. Radiat Environ Biophys 2017. PMID 28144741
Since the standard system of human lymphocytes for measuring dicentrics are not compatible with our microbeam irradiation setup where attaching cells are essential, we used human-hamster hybrid A(L) cells which do attach on foils and fulfil the special experimental requirement for microbeam irradiations. ...These findings indicate that the biological effectiveness in A(L) cells can give important information for human cells, especially for studies where attaching cells are essential....
Since the standard system of human lymphocytes for measuring dicentrics are not compatible with our microbeam irradiation setup where attach …
Bradykinin induces hyperpolarizations in rat glioma cells and in neuroblastoma X glioma hybrid cells.
Reiser G and Hamprecht B. Brain Res 1982. PMID 7093675
The glioma cells showed a desensitization upon repeated application of bradykinin. However, the sensitivity of the cells to bradykinin was restored after 3-8 min of incubation in the absence of bradykinin. ...Bradykinin-elicited hyperpolarizations with characteristics similar to those described above could also be demonstrated in neuroblastoma X glioma hybrid cells, but not in multinucleated fibroblast cells....
The glioma cells showed a desensitization upon repeated application of bradykinin. However, the sensitivity of the cells to br …
Cell fusion is a potent inducer of aneuploidy and drug resistance in tumor cell/ normal cell hybrids.
Berndt B, et al. Crit Rev Oncog 2013 - Review. PMID 23237554
But how the high phenotypic diversity of tumor hybrid cells is achieved? Cell fusion is a strong inducer of aneuploidy and genomic instability in tumor hybrid cells. ...However, due to the aneuploidy/ genomic instability the hybrid cells may originate exhibiting an enhanced adaptation capacity, enabling these cells to withstand cellular stresses....
But how the high phenotypic diversity of tumor hybrid cells is achieved? Cell fusion is a strong inducer of aneuploidy …
Pluripotent hybrid stem cells from transgenic Huntington's disease monkey.
Laowtammathron C and Chan AW. Methods Mol Biol 2013. PMID 23754219
Thus, pluripotent stem cells derived from transgenic HD monkeys could be a useful comparative model for clarifying HD pathogenesis and developing novel therapeutic approaches, which could be validated in HD monkeys. In order to create personal pluripotent stem cells from HD monkeys, here we present a tetraploid technique for deriving pluripotent hybrid HD monkey stem cells....
Thus, pluripotent stem cells derived from transgenic HD monkeys could be a useful comparative model for clarifying HD pathogenesis an …
Localization of [3H]serotonin in neuroblastoma x glioma hybrid cells.
Furuya S, et al. Brain Res 1985. PMID 4084812
Dense core vesicles were abundant in neurites, and less numerous in cell bodies of the hybrid cells. [3H]5-HT taken up into NG108-15 cells was released by potassium stimulation in the presence of Ca2+. The results indicate that NG108-15 hybrid cells manifest many properties comparable to those of serotonergic neurons....
Dense core vesicles were abundant in neurites, and less numerous in cell bodies of the hybrid cells. [3H]5-HT taken up …
Insulin-mediated phosphorylation of ribosomal protein S6 in mouse melanoma cells and melanoma x fibroblast hybrid cells in relation to cell proliferation.
Kulkarni RK and Straus DS. Biochim Biophys Acta 1983. PMID 6347262
In the hybrid cells, under conditions of growth arrest in medium with low serum, ribosomal protein S6 was rapidly phosphorylated in response to insulin or serum. ...The S6 phosphorylation results correlate well with previous results suggesting that the hybrid cells, but not the parental melanoma cells, can become growth-limited for processes regulated by insulin....
In the hybrid cells, under conditions of growth arrest in medium with low serum, ribosomal protein S6 was rapidly phosphorylat …
Analysis of the cell adhesion mechanism using somatic cell hybrids. I. Aggregation of hybrid cells between adhesive V79 and non-adhesive Ehrlich's ascites tumour cells.
Aoyama H, et al. J Cell Sci 1980. PMID 6998992 Free article.
Ehrlich's ascites tumour (EAT) cells are provided with neither Ca2+-dependent nor CA2+-independent mechanisms. Studies on the aggregation of cells of 25 different hybrid clones obtained by fusing these 2 lined cells revealed the following points with regard to adhesive properties of hybrid cells. (1) The activity of the Ca2+-independent mechanism was lower in most hybrid clones than in parental V79 cells. (2) There were a few hybrid clones whose Ca2+-dependent mechanism activity was lower than in V79 cells. In these clones, the Ca2+-independent mechanism was also less active than the parental cells. (3) A hybrid clone with reduced Ca2+-dependent mechanism activity only was not found. (4) All the hybrid clones have at least one set of chromosomes derived from V79. (5) The number of chromosomes derived from EAT cells tended to be less in hybrid clones with lower aggregative ability. ...
Ehrlich's ascites tumour (EAT) cells are provided with neither Ca2+-dependent nor CA2+-independent mechanisms. Studies on the aggrega …
Fusion of mesenchymal stem cells and islet cells for cell therapy.
Sumi S and Yanai G. Methods Mol Biol 2015. PMID 25947659
Auxiliary use of mesenchymal stem/stromal cells (MSCs) to islet transplantation is shown to enhance efficacy. We hypothesized cell fusion of islet cells and MSCs may provide a new cell source with robustness of MSCs and islet cell function. ...Here, we describe our method of cell fusion that enabled us to fuse islet cells to MSCs....
Auxiliary use of mesenchymal stem/stromal cells (MSCs) to islet transplantation is shown to enhance efficacy. We hypothesized cell
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