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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1948 2
1949 2
1950 11
1951 10
1952 48
1953 106
1954 164
1955 300
1956 325
1957 339
1958 322
1959 270
1960 211
1961 206
1962 305
1963 586
1964 815
1965 657
1966 687
1967 815
1968 995
1969 1072
1970 1102
1971 1129
1972 1180
1973 1285
1974 1303
1975 1190
1976 1162
1977 1135
1978 1076
1979 1189
1980 1182
1981 1109
1982 1214
1983 1307
1984 1424
1985 1453
1986 1385
1987 1299
1988 1269
1989 1204
1990 1219
1991 1156
1992 1145
1993 1091
1994 1035
1995 1084
1996 1073
1997 1098
1998 1146
1999 1132
2000 1166
2001 1206
2002 1269
2003 1244
2004 1329
2005 1364
2006 1572
2007 1644
2008 1564
2009 1644
2010 1774
2011 1847
2012 1913
2013 1920
2014 1878
2015 1922
2016 1830
2017 1905
2018 1638
2019 708
2020 8
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71,199 results
Results by year
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Page 1
Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation: A Randomized Clinical Trial.
Onland W, et al. JAMA 2019 - Clinical Trial. PMID 30694322 Free PMC article.
Hydrocortisone is increasingly used as an alternative, but evidence supporting its efficacy and safety is lacking. OBJECTIVE: To assess the effect of hydrocortisone initiated between 7 and 14 days after birth on death or BPD in very preterm infants. ...These findings do not support the use of hydrocortisone for this indication. TRIAL REGISTRATION: Netherlands National Trial Register Identifier: NTR2768....
Hydrocortisone is increasingly used as an alternative, but evidence supporting its efficacy and safety is lacking. OBJECTIVE: To asse
Hydrocortisone in Vasodilatory Shock.
Venkatesh B and Cohen J. Crit Care Clin 2019 - Review. PMID 30784608
Lower dosage steroid use was driven by trials demonstrating improved hemodynamic status and the possibility of relative adrenal insufficiency; however, divergent results led to uncertainty about hydrocortisone treatment. ...Future work could include elucidating mechanisms of shock reversal, interaction of hydrocortisone with other agents, identifying steroid responsiveness using biochemical or gene signatures, and clarifying the role of fludrocortisone....
Lower dosage steroid use was driven by trials demonstrating improved hemodynamic status and the possibility of relative adrenal insufficienc …
Adrenal Crisis
Rushworth RL, et al. N Engl J Med 2019 - Review. PMID 31461595
Efficacy and safety of systemic hydrocortisone for the prevention of bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis.
Morris IP, et al. Eur J Pediatr 2019. PMID 31144162 Free PMC article.
After filtering, 12 studies using early (within 1 week of birth) and two using late hydrocortisone were identified. Early systemic hydrocortisone significantly increased the chances of survival without BPD (RR 1.13, 95% CI [1.01, 1.26], NNT 18), and survival without moderate-to-severe neurodevelopmental impairment (1.13 [1.02, 1.26], NNT 14). Infants who received hydrocortisone had a higher risk of intestinal perforation (1.69 [1.07, 2.68], NNH 30), primarily with concurrent treatment for patent ductus arteriosus.Conclusion: Early systemic hydrocortisone is a modestly effective therapy for the prevention of BPD in preterm infants, although some safety concerns remain. ...
After filtering, 12 studies using early (within 1 week of birth) and two using late hydrocortisone were identified. Early systemic …
Preface
Litwack G. Vitam Horm 2019. PMID 30678868
Adrenal function and dysfunction in critically ill patients
Téblick A, et al. Nat Rev Endocrinol 2019 - Review. PMID 30850749
This concept triggered several randomized clinical trials on the impact of large stress doses of hydrocortisone to treat CIRCI, which gave conflicting results. ...
This concept triggered several randomized clinical trials on the impact of large stress doses of hydrocortisone to treat CIRCI, which …
71,199 results
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