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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1948 1
1949 1
1952 3
1953 2
1954 1
1955 5
1956 4
1957 3
1958 1
1959 4
1960 5
1961 6
1965 11
1966 6
1967 22
1968 25
1969 20
1970 36
1971 33
1972 43
1973 69
1974 46
1975 55
1976 45
1977 56
1978 99
1979 95
1980 113
1981 104
1982 120
1983 98
1984 145
1985 103
1986 194
1987 137
1988 144
1989 161
1990 155
1991 204
1992 217
1993 218
1994 228
1995 328
1996 333
1997 344
1998 387
1999 374
2000 424
2001 396
2002 385
2003 423
2004 437
2005 418
2006 426
2007 446
2008 483
2009 494
2010 507
2011 500
2012 549
2013 489
2014 478
2015 517
2016 462
2017 454
2018 382
2019 167
2020 1
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12,749 results
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Page 1
Genetics of hypertension. Current status.
Butler MG. J Med Liban 2010 - Review. PMID 21462849 Free PMC article.
Genetics of hypertension is complex with no known single gene playing a major role, but rather many genes each with mild effects reacting to different environmental stimuli contribute to blood pressure. ...New approaches will allow for identification of not only single genes, but other interacting genes contributing to hypertension by merging multiple genetic data sets (structural and functional) from individuals with hypertension and development of new molecular targets for study and treatment....
Genetics of hypertension is complex with no known single gene playing a major role, but rather many genes each with mild effects reac …
Genetics of Human Primary Hypertension: Focus on Hormonal Mechanisms.
Manosroi W and Williams GH. Endocr Rev 2019 - Review. PMID 30590482 Free PMC article.
These 21 genes were organized in a four-tiered structure: distant phenotype (hypertension); intermediate phenotype [salt-sensitive (18) or salt-resistant (0)]; subintermediate phenotypes under salt-sensitive hypertension [normal renin (4), low renin (8), and unclassified renin (6)]; and proximate phenotypes (specific genetically driven hypertensive subgroup). Many proximate hypertensive phenotypes had a substantial endocrine component. In conclusion, primary hypertension is a syndrome; many proposed genes are likely to be false positives; and deep phenotyping will be required to determine the utility of genetics in the treatment of hypertension. ...
These 21 genes were organized in a four-tiered structure: distant phenotype (hypertension); intermediate phenotype [salt-sensitive (1 …
Epigenetic Mechanisms and Hypertension.
Liang M. Hypertension 2018 - Review. PMID 30571238 Free PMC article.
Pathogenesis of hypertension.
Oparil S, et al. Ann Intern Med 2003 - Review. PMID 14597461
Genetics of hypertension: discoveries from the bench to human populations.
Franceschini N and Le TH. Am J Physiol Renal Physiol 2014. PMID 24133117 Free PMC article.
Hypertension is a complex trait that is influenced by both heritable and environmental factors. The search for genes accounting for the susceptibility to hypertension has driven parallel efforts in human research and in research using experimental animals in controlled environmental settings. Evidence from rodent models of genetic hypertension and human Mendelian forms of hypertension and hypotension have yielded mechanistic insights into the pathways that are perturbed in blood pressure homeostasis, most of which converge at the level of renal sodium reabsorption. ...
Hypertension is a complex trait that is influenced by both heritable and environmental factors. The search for genes accounting for t
Personalized Medicine and the Treatment of Hypertension.
Melville S and Byrd JB. Curr Hypertens Rep 2019 - Review. PMID 30747306 Free PMC article.
PURPOSE OF REVIEW: The purpose of this review is to discuss the implications of personalized medicine for the treatment of hypertension, including resistant hypertension. ...Clinicians seeing patients with unusual hypertension phenotypes should be familiar with emerging trends in personalized treatment of hypertension....
PURPOSE OF REVIEW: The purpose of this review is to discuss the implications of personalized medicine for the treatment of hypertension
Hypertension pharmacogenomics: in search of personalized treatment approaches.
Cooper-DeHoff RM and Johnson JA. Nat Rev Nephrol 2016 - Review. PMID 26592190 Free PMC article.
Cardiovascular and renal diseases are associated with many risk factors, of which hypertension is one of the most prevalent. ...Hypertension pharmacogenomics and other 'omics' technologies have the potential to identify genetic signals that are predictive of response or adverse outcome to particular drugs, and guide selection of hypertension treatment for a given individual. ...
Cardiovascular and renal diseases are associated with many risk factors, of which hypertension is one of the most prevalent. ...Hy
Genomic Approaches to Hypertension.
Dodoo SN and Benjamin IJ. Cardiol Clin 2017 - Review. PMID 28411893
Genomic insights and analyses of Mendelian hypertension (HTN) syndromes and Genome-Wide Association study (GWAS) on essential hypertension have contributed to the depth of understanding of the genetics origins of hypertension. ...The clinical impact of findings of on essential hypertension is continuously evolving, and the insights accrued will refine efforts to combat the societal impact of hypertension. ...
Genomic insights and analyses of Mendelian hypertension (HTN) syndromes and Genome-Wide Association study (GWAS) on essential hype
Genetics of human hypertension.
Ruppert V and Maisch B. Herz 2003 - Review. PMID 14689098
BACKGROUND: Hypertension is a multifactorial disease involving interactions among genetic, environmental, demographic, vascular and neuroendocrine factors. Essential hypertension is the most frequent diagnosis in this syndrome, indicating that a monocausal etiology has not been identified. ...
BACKGROUND: Hypertension is a multifactorial disease involving interactions among genetic, environmental, demographic, vascular and n …
Genetics of hypertension: the adducin paradigm.
Bianchi G and Tripodi G. Ann N Y Acad Sci 2003 - Review. PMID 12763916
The following were investigated: (1) how we became interested in studying adducin genes and what we know about adducin; (2) studies in animals and humans supporting the role of adducin polymorphisms in hypertension, including some methodological problems related to the dissection of the role of a given genetic molecular mechanism in a complex multifactorial polygenic disease like hypertension; (3) biochemical mechanisms underlying the effect of adducin and its interaction with the Na-K pump; and (4) future directions....
The following were investigated: (1) how we became interested in studying adducin genes and what we know about adducin; (2) studies in anima …
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