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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 7
1946 17
1947 23
1948 25
1949 24
1950 36
1951 84
1952 108
1953 136
1954 229
1955 194
1956 248
1957 233
1958 232
1959 235
1960 269
1961 265
1962 294
1963 343
1964 422
1965 271
1966 235
1967 233
1968 312
1969 300
1970 272
1971 311
1972 307
1973 318
1974 362
1975 237
1976 241
1977 221
1978 215
1979 232
1980 194
1981 184
1982 209
1983 259
1984 243
1985 252
1986 238
1987 196
1988 215
1989 232
1990 242
1991 259
1992 232
1993 274
1994 271
1995 390
1996 556
1997 547
1998 556
1999 614
2000 525
2001 516
2002 544
2003 556
2004 661
2005 719
2006 814
2007 793
2008 864
2009 950
2010 928
2011 1004
2012 1088
2013 1138
2014 1198
2015 1095
2016 1180
2017 1215
2018 1065
2019 497
2020 11
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29,245 results
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Page 1
Mortality Risk of Hypnotics: Strengths and Limits of Evidence.
Kripke DF. Drug Saf 2016 - Review. PMID 26563222 Free article.
Sleeping pills, more formally defined as hypnotics, are sedatives used to induce and maintain sleep. In a review of publications for the past 30 years, descriptive epidemiologic studies were identified that examined the mortality risk of hypnotics and related sedative-anxiolytics. ...Epidemiologic association in itself is not adequate proof of causality, but there is proof that hypnotics cause death in overdoses; there is thorough understanding of how hypnotics euthanize animals and execute humans; and there is proof that hypnotics cause potentially lethal morbidities such as depression, infection, poor driving, suppressed respiration, and possibly cancer. ...
Sleeping pills, more formally defined as hypnotics, are sedatives used to induce and maintain sleep. In a review of publicatio …
Zolpidem's use for insomnia
Monti JM, et al. Asian J Psychiatr 2017 - Review. PMID 28262178
Pharmacotherapy Treatment Options for Insomnia: A Primer for Clinicians
Asnis GM, et al. Int J Mol Sci 2015 - Review. PMID 26729104 Free PMC article.
Cognizant of this and as a result of longer-term studies, the FDA has approved all hypnotics since 2005 without restricting the duration of use. Our manuscript also reviews off-label hypnotics (sedating antidepressants, atypical antipsychotics, anticonvulsants and antihistamines) which in reality, are more often prescribed than approved hypnotics. ...
Cognizant of this and as a result of longer-term studies, the FDA has approved all hypnotics since 2005 without restricting the durat …
Sedation of mechanically ventilated adults in intensive care unit: a network meta-analysis
Zhang Z, et al. Sci Rep 2017 - Review. PMID 28322337 Free PMC article.
Sedatives are commonly used for mechanically ventilated patients in intensive care units (ICU). However, a variety of sedatives are available and their efficacy and safety have been compared in numerous trials with inconsistent results. To resolve uncertainties regarding usefulness of these sedatives, we performed a systematic review and network meta-analysis. ...
Sedatives are commonly used for mechanically ventilated patients in intensive care units (ICU). However, a variety of sedatives
Hypnotic Discontinuation in Chronic Insomnia
Hintze JP and Edinger JD. Sleep Med Clin 2018 - Review. PMID 29759276
The long-term effects of chronic hypnotics are not known and discontinuation is encouraged but often difficult to achieve. A gradual taper is preferred to abrupt cessation to avoid rebound insomnia and withdrawal symptoms. ...
The long-term effects of chronic hypnotics are not known and discontinuation is encouraged but often difficult to achieve. A gradual …
A systematic review of regulatory and educational interventions to reduce the burden associated with the prescriptions of sedative-hypnotics in adults treated for sleep disorders.
Bourcier E, et al. PLoS One 2018 - Review. PMID 29357377 Free PMC article.
BACKGROUND: The burden of Sedative-Hypnotics (SHs) has been known since the 1980s. Yet, their consumption remains high. A systematic review of the literature should help to assess efficient interventions to improve the appropriate use of SHs in sleep disorders. ...
BACKGROUND: The burden of Sedative-Hypnotics (SHs) has been known since the 1980s. Yet, their consumption remains high. A systematic …
Simultaneous analysis by Quadrupole-Orbitrap mass spectrometry and UHPLC-MS/MS for the determination of sedative-hypnotics and sleep inducers in adulterated products.
Lee JH, et al. J Sep Sci 2017. PMID 29057572
In this study, we developed and validated a method for determining synthetic sedative-hypnotics and sleep inducers, including barbital, benzodiazepam, zolpidem, and first-generation antihistamines, in adulterated products using Quadrupole-Orbitrap mass spectrometry and ultrahigh performance liquid chromatography with tandem mass spectrometry. ...
In this study, we developed and validated a method for determining synthetic sedative-hypnotics and sleep inducers, including barbita …
29,245 results
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