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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 26
1946 82
1947 101
1948 112
1949 56
1950 130
1951 179
1952 178
1953 158
1954 204
1955 197
1956 204
1957 216
1958 199
1959 176
1960 182
1961 199
1962 237
1963 420
1964 558
1965 393
1966 369
1967 330
1968 400
1969 391
1970 404
1971 423
1972 423
1973 450
1974 347
1975 425
1976 457
1977 516
1978 484
1979 449
1980 449
1981 406
1982 411
1983 442
1984 492
1985 502
1986 569
1987 613
1988 614
1989 749
1990 711
1991 665
1992 655
1993 709
1994 720
1995 758
1996 730
1997 732
1998 710
1999 684
2000 788
2001 750
2002 795
2003 921
2004 917
2005 1039
2006 1001
2007 1108
2008 1170
2009 1098
2010 1179
2011 1201
2012 1215
2013 1285
2014 1370
2015 1409
2016 1419
2017 1332
2018 1154
2019 503
2020 9
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41,591 results
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Page 1
Hypoxia: From Placental Development to Fetal Programming.
Fajersztajn L and Veras MM. Birth Defects Res 2017 - Review. PMID 29105382
Hypoxia may influence normal and different pathological processes. Low oxygenation activates a variety of responses, many of them regulated by hypoxia-inducible factor 1 complex, which is mostly involved in cellular control of O(2) consumption and delivery, inhibition of growth and development, and promotion of anaerobic metabolism. ...In this review, the role of hypoxia in fetal development, placentation, and fetal programming is summarized. Hypoxia is a basic mechanism involved in different pregnancy disorders and fetal health developmental complications. ...
Hypoxia may influence normal and different pathological processes. Low oxygenation activates a variety of responses, many of them reg
The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases.
Abe H, et al. J Atheroscler Thromb 2017 - Review. PMID 28757538 Free PMC article.
While tissue hypoxia can be induced because of cardiovascular disorders, hypoxia signaling itself has a potential to modulate tissue remodeling processes or the severity of the cardiovascular disorders. Hypoxia inducible factor-1α (HIF-1α) and HIF-2α belongs to a group of transcription factors which mediate most of the cellular responses to hypoxia at a transcriptional level. ...
While tissue hypoxia can be induced because of cardiovascular disorders, hypoxia signaling itself has a potential to modulate …
Tissue hypoxia: implications for the respiratory clinician.
MacIntyre NR. Respir Care 2014 - Review. PMID 25161296 Free article.
Hypoxia is the presence of lower than normal oxygen content and pressure in the cell. Causes of hypoxia include hypoxemia (low blood oxygen content and pressure), impaired oxygen delivery, and impaired cellular oxygen uptake/utilization. ...We also need to focus on understanding and better harnessing the body's own adaptive mechanisms to hypoxia....
Hypoxia is the presence of lower than normal oxygen content and pressure in the cell. Causes of hypoxia include hypoxemia (low
Hypoxia-induced intestinal barrier changes in balloon-assisted enteroscopy.
Lee TC, et al. J Physiol 2018 - Clinical Trial. PMID 29178568 Free PMC article.
Balloon distension by BAE caused gut tissue hypoxia. The impact of balloon distension-induced hypoxia on intestinal barriers remains unclear. ...Short-term hypoxia by balloon distension yielded a protective effect whereas long-term hypoxia caused damage to the gut barrier....
Balloon distension by BAE caused gut tissue hypoxia. The impact of balloon distension-induced hypoxia on intestinal barriers r …
Hypoxia as a target for tissue specific gene therapy.
Rhim T, et al. J Control Release 2013 - Review. PMID 23742881
The hypoxia inducible promoters and enhancers have been evaluated as a transcriptional regulation tool for hypoxia inducible gene therapy. ...In this review, hypoxia inducible gene expression systems are discussed and their applications are introduced....
The hypoxia inducible promoters and enhancers have been evaluated as a transcriptional regulation tool for hypoxia inducible g …
[Hypoxia or hypoxemia?].
Vikse J and Gjøse BF. Tidsskr Nor Laegeforen 2017. PMID 28383233 Norwegian. Free article.
Moderate and severe hypoxia elicit divergent effects on cardiovascular function and physiological rhythms.
Allwood MA, et al. J Physiol 2018. PMID 29604069 Free PMC article.
ABSTRACT: Hypoxia is both a consequence and cause of many acute and chronic diseases. Severe hypoxia causes hypertension with cardiovascular sequelae; however, the rare studies using moderate severities of hypoxia indicate that it can be beneficial, suggesting that hypoxia may not always be detrimental. ...Severe but not moderate hypoxia increased the low/high frequency ratio of heart rate variability 72 h post-hypoxia, indicating a shift in sympathovagal balance. ...
ABSTRACT: Hypoxia is both a consequence and cause of many acute and chronic diseases. Severe hypoxia causes hypertension with …
Intermittent hypoxia: a low-risk research tool with therapeutic value in humans.
Mateika JH, et al. J Appl Physiol (1985) 2015 - Review. PMID 25549763 Free article.
In contrast, the link between intermittent hypoxia and beneficial outcomes has received less attention, perhaps because it is not universally understood that outcome measures following exposure to intermittent hypoxia may be linked to the administered dose. The present review is designed to emphasize the less recognized beneficial outcomes associated with intermittent hypoxia. The review will consider the role intermittent hypoxia has in cardiovascular and autonomic adaptations, respiratory motor plasticity, and cognitive function. ...
In contrast, the link between intermittent hypoxia and beneficial outcomes has received less attention, perhaps because it is not uni …
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