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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 26
1946 82
1947 101
1948 112
1949 56
1950 130
1951 179
1952 178
1953 158
1954 204
1955 197
1956 204
1957 216
1958 199
1959 176
1960 182
1961 199
1962 237
1963 422
1964 569
1965 482
1966 560
1967 621
1968 831
1969 905
1970 872
1971 1056
1972 993
1973 1013
1974 904
1975 934
1976 861
1977 920
1978 902
1979 830
1980 837
1981 709
1982 760
1983 791
1984 832
1985 856
1986 937
1987 900
1988 885
1989 1057
1990 1053
1991 1017
1992 993
1993 1052
1994 1067
1995 1165
1996 1133
1997 1114
1998 1062
1999 1054
2000 1170
2001 1188
2002 1235
2003 1437
2004 1464
2005 1627
2006 1621
2007 1701
2008 1816
2009 1803
2010 1857
2011 1903
2012 1956
2013 2017
2014 2118
2015 2161
2016 2209
2017 2146
2018 1879
2019 867
2020 13
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66,165 results
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Epigenetic changes by DNA methylation in chronic and intermittent hypoxia.
Nanduri J, et al. Am J Physiol Lung Cell Mol Physiol 2017 - Review. PMID 28839104 Free PMC article.
Hypoxia is a pervasive stimulus that affects many physiological processes. The circulatory and respiratory systems adapt to chronic sustained hypoxia, such as that encountered during a high-altitude sojourn. ...This article presents a brief update on emerging evidence suggesting that changes in DNA methylation contribute to pathologies caused by chronic IH and potentially mediate adaptations to chronic sustained hypoxia by affecting the hypoxia-inducible factor (HIF) signaling pathway....
Hypoxia is a pervasive stimulus that affects many physiological processes. The circulatory and respiratory systems adapt to chronic s
miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target.
Serocki M, et al. Angiogenesis 2018 - Review. PMID 29383635 Free PMC article.
HIF-1 governs the acute adaptation to hypoxia, whereas HIF-2 and HIF-3 expressions begin during chronic hypoxia in human endothelium. ...This switch from HIF-1 to HIF-2 and HIF-3 signaling is required in order to adapt the endothelium to prolonged hypoxia. During prolonged hypoxia, the HIF-1 levels and activity are reduced, despite the lack of oxygen-dependent protein degradation. ...
HIF-1 governs the acute adaptation to hypoxia, whereas HIF-2 and HIF-3 expressions begin during chronic hypoxia in human endot …
Tissue hypoxia: implications for the respiratory clinician.
MacIntyre NR. Respir Care 2014 - Review. PMID 25161296 Free article.
Hypoxia is the presence of lower than normal oxygen content and pressure in the cell. Causes of hypoxia include hypoxemia (low blood oxygen content and pressure), impaired oxygen delivery, and impaired cellular oxygen uptake/utilization. ...We also need to focus on understanding and better harnessing the body's own adaptive mechanisms to hypoxia....
Hypoxia is the presence of lower than normal oxygen content and pressure in the cell. Causes of hypoxia include hypoxemia (low
Preconditioning in neuroprotection: From hypoxia to ischemia.
Li S, et al. Prog Neurobiol 2017 - Review. PMID 28110083 Free PMC article.
Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even organisms from subsequent lethal injury caused by hypoxia or ischemia. ...
Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even organisms from subsequent lethal injury caused b …
Hypoxia-Induced Signaling Activation in Neurodegenerative Diseases: Targets for New Therapeutic Strategies.
Jha NK, et al. J Alzheimers Dis 2018 - Review. PMID 29439330
Further, hypoxia resulting in reduced O2 deliveries to brain tissues is supposed to cause neurodegeneration in both in vivo and in vitro models. ...Additionally, the involvement of numerous pharmacological approaches to compensate hypoxia-induced neuronal damage has also been addressed, which may be considered as a potential therapeutic approach in hypoxia-mediated neurodegeneration....
Further, hypoxia resulting in reduced O2 deliveries to brain tissues is supposed to cause neurodegeneration in both in vivo and in vi …
Therapeutic potential of intermittent hypoxia: a matter of dose.
Navarrete-Opazo A and Mitchell GS. Am J Physiol Regul Integr Comp Physiol 2014 - Review. PMID 25231353 Free PMC article.
Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and triggers a bewildering array of both detrimental and beneficial effects in multiple physiological systems. ...Modest hypoxia (9-16% inspired O2) and low cycle numbers (3-15 episodes per day) most often lead to beneficial effects without pathology, whereas severe hypoxia (2-8% inspired O2) and more episodes per day (48-2,400 episodes/day) elicit progressively greater pathology. ...
Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and triggers a bewildering array of both det …
Translation in progress: hypoxia.
Roach RC, et al. J Appl Physiol (1985) 2014. PMID 24557798 Free article.
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