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Single- and Multiple-Dose Pharmacokinetics, Safety and Tolerability of Lurasidone in Healthy Chinese Subjects.
Hu C, Wang Y, Song R, Yu C, Luo X, Jia J. Hu C, et al. Clin Drug Investig. 2017 Sep;37(9):861-871. doi: 10.1007/s40261-017-0546-8. Clin Drug Investig. 2017. PMID: 28695535 Clinical Trial.
Similar results were observed for the metabolites (ID-14283, ID-14326, and ID-11614). No severe adverse events (AEs) were observed in the single- or multiple-dose studies and no subject discontinued from the study due to AEs. ...
Similar results were observed for the metabolites (ID-14283, ID-14326, and ID-11614). No severe adverse events (AEs) were obse …
Distribution of perospirone to melanin in pigmented rats.
Mizuno Y, Komuro S, Kanamaru H. Mizuno Y, et al. Eur J Drug Metab Pharmacokinet. 2003 Jan-Mar;28(1):73-9. doi: 10.1007/BF03190870. Eur J Drug Metab Pharmacokinet. 2003. PMID: 14503668
Among radioactive components in eyeballs after administration of [CO-14C]perospirone, ratios of ID-15036 and MX11 followed by unchanged compound and MX9 are high. After administration of [TH-14C]perospirone, ID-11614 accounted for nearly half of the radioactivity. V …
Among radioactive components in eyeballs after administration of [CO-14C]perospirone, ratios of ID-15036 and MX11 followed by unchanged comp …
In vitro metabolism of perospirone in rat, monkey and human liver microsomes.
Mizuno Y, Tani N, Komuro S, Kanamaru H, Nakatsuka I. Mizuno Y, et al. Eur J Drug Metab Pharmacokinet. 2003 Jan-Mar;28(1):59-65. doi: 10.1007/BF03190868. Eur J Drug Metab Pharmacokinet. 2003. PMID: 14503666
In vitro metabolism of perospirone was examined with rat, monkey and human liver S9, human liver microsomes and yeast microsomes expressing human P450, using 14C labeled perospirone. With rat liver S9, the major metabolites were MX9 and ID-11614, produced by cleavag …
In vitro metabolism of perospirone was examined with rat, monkey and human liver S9, human liver microsomes and yeast microsomes expressing …