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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 3
2006 9
2007 8
2008 17
2009 14
2010 24
2011 29
2012 23
2013 27
2014 32
2015 32
2016 23
2017 25
2018 27
2019 13
2020 0
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271 results
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Page 1
Protein Expression and Genetic Variation of IL32 and Association with Colorectal Cancer in Swedish Patients.
Shamoun L, et al. Anticancer Res 2018. PMID 29277790 Free article.
The expression of IL32 protein was confirmed by immunohistochemistry (n=73). We used Luminex technology to investigate protein levels of the cytokines IL6, tumor necrosis factor-α (TNFα) and vascular endothelial growth factor (VEGF) to relate these to IL32 levels in CRC tissue. ...The IL32 protein level in CRC tissue also reflects both disseminated disease and location. CONCLUSION: Our results suggest that altered IL32 protein concentrations in CRC tissue and genotypic variants of IL32 are related to disseminated CRC....
The expression of IL32 protein was confirmed by immunohistochemistry (n=73). We used Luminex technology to investigate prot
Interleukin 32, inflammation and cancer
Hong JT, et al. Pharmacol Ther 2017 - Review. PMID 28223235
Earlier studies have demonstrated that IL-32 regulates cell growth, metabolism and immune regulation and is therefore involved in the pathologic regulator or protectant of inflammatory diseases. ...
Earlier studies have demonstrated that IL-32 regulates cell growth, metabolism and immune regulation and is therefore involved in the pathol …
Insights into the role of IL-32 in cancer
Sloot YJE, et al. Semin Immunol 2018 - Review. PMID 29747940
IL-32 is a rather peculiar cytokine because its protein structure does not show resemblance with any of the known cytokines, and an IL-32 receptor to facilitate extracellular signaling has not yet been identified. ...
IL-32 is a rather peculiar cytokine because its protein structure does not show resemblance with any of the known cytokines, and an I …
Editorial
Kennedy DW. Int Forum Allergy Rhinol 2016. PMID 27717248
Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3-p38 MAPK signalling.
Wen S, et al. Cancer Lett 2019. PMID 30391782 Free article.
Counteracting IL32 activity, a knockdown of IL32 or integrin β3 led to specific inactivation of p38 MAPK signalling in tumour cells. ...Thus, our data indicate that CAF-secreted IL32 promotes breast cancer cell invasion and metastasis via integrin β3-p38 MAPK signalling....
Counteracting IL32 activity, a knockdown of IL32 or integrin β3 led to specific inactivation of p38 MAPK signalling in tumour …
DNA methylation at IL32 in juvenile idiopathic arthritis.
Meyer B, et al. Sci Rep 2015. PMID 26057774 Free PMC article.
We recently showed that DNA methylation at the gene encoding the pro-inflammatory cytokine interleukin-32 (IL32) is reduced in JIA CD4+ T cells. ...Overall, our data further confirms that reduced IL32 methylation is associated with JIA, and that SNPs play an interactive role....
We recently showed that DNA methylation at the gene encoding the pro-inflammatory cytokine interleukin-32 (IL32) is reduced in JIA CD …
Impact of intra-tumoral IL17A and IL32 gene expression on T-cell responses and lymph node status in breast cancer patients.
Bhat S, et al. J Cancer Res Clin Oncol 2017. PMID 28470472 Free PMC article.
ER-negative tumors also showed higher expression of IL32 as opposed to ER-positive tumors (8.7 vs 2.5-fold, p < 0.01). Expression of both IL17A and IL32 genes positively correlated with CCL5, GNLY, TBX21, IL21 and IL23 transcript levels (p < 0.01). ...Of note, these tumors were characterized by low expression of a potentially immunosuppressive isoform of IL32 (IL32γ). CONCLUSION: These results suggest that high expression of both IL17A and IL32 leads to enhancement of T cell responses. ...

ER-negative tumors also showed higher expression of IL32 as opposed to ER-positive tumors (8.7 vs 2.5-fold, p < 0.01). Expression

IL32 is progressively expressed in mycosis fungoides independent of helper T-cell 2 and helper T-cell 9 polarization.
Ohmatsu H, et al. Cancer Immunol Res 2014. PMID 24938282 Free PMC article.
By IHC and immunofluorescence, we confirmed IL32 protein expression in many CD3(+)CD4(+) T cells and some epidermotropic T cells in mycosis fungoides lesions. ...In conclusion, we have identified IL32(+) cells as the likely tumor cells in mycosis fungoides, and demonstrated that IL32 mRNA expression increases with mycosis fungoides progression and is significantly higher than mRNA expression in other skin diseases, and that some IL32(+) T cells are independent from the defined Th subsets. ...
By IHC and immunofluorescence, we confirmed IL32 protein expression in many CD3(+)CD4(+) T cells and some epidermotropic T cel …
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