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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2001 7
2002 10
2003 7
2004 5
2005 8
2006 7
2007 3
2008 10
2009 12
2010 21
2011 19
2012 30
2013 31
2014 41
2015 40
2016 27
2017 24
2018 16
2019 10
2020 1
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293 results
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Page 1
A human immune system mouse model with robust lymph node development.
Li Y, et al. Nat Methods 2018. PMID 30065364
Human immune system (HIS) mice are powerful tools for interrogation of human immunity but lack secondary lymphoid tissue (SLT) as a result of a deficiency in Il2rg-dependent lymphoid tissue inducer cells. To restore LN development, we induced expression of thymic-stromal-cell-derived lymphopoietin (TSLP) in a Balb/c Rag2(-/-)Il2rg(-/-)Sirpa(NOD) (BRGS) HIS mouse model. ...
Human immune system (HIS) mice are powerful tools for interrogation of human immunity but lack secondary lymphoid tissue (SLT) as a result o …
Humanized mice for immune system investigation: progress, promise and challenges
Shultz LD, et al. Nat Rev Immunol 2012 - Review. PMID 23059428 Free PMC article.
Significant advances in our understanding of the in vivo functions of human cells and tissues and the human immune system have resulted from the development of 'humanized' mouse strains that are based on severely immunodeficient mice with mutations in the interleukin-2 receptor common γ-chain locus. These mouse strains support the engraftment of a functional human immune system and permit detailed analyses of human immune biology, development and functions. ...
Significant advances in our understanding of the in vivo functions of human cells and tissues and the human immune system have resulted from …
Efficient derivation of extended pluripotent stem cells from NOD-scid Il2rg(-/-) mice.
Du Y, et al. Protein Cell 2019. PMID 29948854 Free PMC article.
Our study demonstrates the feasibility of generating EPS cells from refractory mouse strains, which could potentially be a general strategy for deriving mouse pluripotent cells. The generation of NOD-scid Il2rg(-/-) EPS cell lines permits sophisticated genetic modification in NOD-scid Il2rg(-/-) mice, which may greatly advance the optimization of humanized mouse models for biomedical applications....
Our study demonstrates the feasibility of generating EPS cells from refractory mouse strains, which could potentially be a general st …
Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy
Charych D, et al. PLoS One 2017. PMID 28678791 Free PMC article.
NKTR-214 is a clinical-stage biologic that comprises interleukin-2 (IL2) protein bound by multiple releasable polyethylene glycol (PEG) chains. ...The model reveals that conjugated-IL2 protein derived from NKTR-214 occupy IL-2Rβγ to a greater extent compared to free-IL2 protein. ...
NKTR-214 is a clinical-stage biologic that comprises interleukin-2 (IL2) protein bound by multiple releasable polyethylene glycol (PE …
Improved multilineage human hematopoietic reconstitution and function in NSGS mice
Wunderlich M, et al. PLoS One 2018. PMID 30540841 Free PMC article.
Here, we have compared the engraftment and output of umbilical cord blood (UCB) CD34+ cells in four immune-deficient strains: NS, NS with additional IL2RG knockout (NSG), NS with transgenic expression of human myeloid promoting cytokines SCF, GM-CSF, and IL-3 (NSS), and NS with both IL2RG knockout and transgenic cytokine expression (NSGS). Overall engraftment of human hematopoietic cells was highest in the IL2RG knockout strains (NSG and NSGS), while myeloid cell output was notably enhanced in the two strains with transgenic cytokine expression (NSS and NSGS). ...
Here, we have compared the engraftment and output of umbilical cord blood (UCB) CD34+ cells in four immune-deficient strains: NS, NS with ad …
Decitabine enhances targeting of AML cells by CD34(+) progenitor-derived NK cells in NOD/SCID/IL2Rg(null) mice.
Cany J, et al. Blood 2018. PMID 29138222 Free PMC article.
In vivo, both agents exerted a significant delay in AML progression in NOD/SCID/IL2Rg(null) mice, but the persistence of adoptively transferred HSPC-NK cells was not affected. ...
In vivo, both agents exerted a significant delay in AML progression in NOD/SCID/IL2Rg(null) mice, but the persistence of adoptively t …
Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2Rγnull Immunodeficient Mice
Sanmamed MF, et al. Cancer Res 2015. PMID 26113085 Free article.
Our results offer a proof of concept for the use of humanized mouse models for surrogate efficacy and histology investigations of immune checkpoint drugs and their combinations....
Our results offer a proof of concept for the use of humanized mouse models for surrogate efficacy and histology investigations of imm …
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
Shultz LD, et al. J Immunol 2005. PMID 15879151 Free article.
Coadministration of human Fc-IL7 fusion protein results in high percentages of human CD4(+)CD8(+) thymocytes as well human CD4(+)CD8(-) and CD4(-)CD8(+) peripheral blood and splenic T cells. ...
Coadministration of human Fc-IL7 fusion protein results in high percentages of human CD4(+)CD8(+) thymocytes as well human CD4(+)CD8( …
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