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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 6
1959 85
1960 106
1961 123
1962 158
1963 207
1964 237
1965 141
1966 141
1967 212
1968 234
1969 257
1970 200
1971 241
1972 242
1973 223
1974 276
1975 235
1976 208
1977 196
1978 178
1979 216
1980 190
1981 194
1982 243
1983 249
1984 262
1985 266
1986 262
1987 240
1988 250
1989 270
1990 223
1991 239
1992 191
1993 172
1994 179
1995 155
1996 162
1997 155
1998 134
1999 116
2000 114
2001 132
2002 116
2003 100
2004 88
2005 101
2006 100
2007 104
2008 107
2009 99
2010 113
2011 88
2012 91
2013 72
2014 82
2015 91
2016 82
2017 72
2018 49
2019 30
2020 0
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9,904 results
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Page 1
Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial.
Cheong PK, et al. Lancet Gastroenterol Hepatol 2018 - Clinical Trial. PMID 30361080 Free article.
We aimed to assess the safety and efficacy of imipramine, a tricyclic antidepressant (TCA), in treatment-refractory functional dyspepsia. ...FINDINGS: Between Sept 11, 2005, and Aug 20, 2010, 107 patients with treatment-refractory functional dyspepsia were randomly assigned to receive imipramine (n=55) or placebo (n=52). ...
We aimed to assess the safety and efficacy of imipramine, a tricyclic antidepressant (TCA), in treatment-refractory functional dyspep …
Imipramine-induced hyperpigmentation.
Bicknell LM, et al. Cutis 2017. PMID 29121138
Imipramine is a tricyclic medication that has been used for the treatment of depression and other mood disorders. Although rare, a slate gray discoloration of sun-exposed skin may occur in patients taking this medication. We present the case of a 63-year-old woman who had been taking imipramine for depression for more than 20 years when she developed a bluish gray discoloration on the face and neck that was diagnosed as imipramine-induced hyperpigmentation based on histopathology and clinical history. ...
Imipramine is a tricyclic medication that has been used for the treatment of depression and other mood disorders. Although rare, a sl
Impact of imipramine on proteome of rat primary glial cells.
Kedracka-Krok S, et al. J Neuroimmunol 2018. PMID 29759138
One of the most pronounced effect of imipramine is the reduction of vimentin level, this protein is engaged in majority of biological processes which were found to be affected by imipramine. Many imipramine regulated proteins, including chaperones, cathepsins and annexins are involved in immune responses. Additionally, imipramine influenced proteins associated with phagocytosis and cell migration. ...
One of the most pronounced effect of imipramine is the reduction of vimentin level, this protein is engaged in majority of biological …
Ketamine and Imipramine Reverse Transcriptional Signatures of Susceptibility and Induce Resilience-Specific Gene Expression Profiles.
Bagot RC, et al. Biol Psychiatry 2017. PMID 27569543 Free PMC article.
RESULTS: We identified similar numbers of responders and nonresponders after ketamine or imipramine treatment. Ketamine induced more expression changes in the hippocampus; imipramine induced more expression changes in the nucleus accumbens and amygdala. ...In addition, we found region-specific effects of each drug, suggesting both common and unique effects of imipramine versus ketamine....
RESULTS: We identified similar numbers of responders and nonresponders after ketamine or imipramine treatment. Ketamine induced more …
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis
Cipriani A, et al. Lancet 2016. PMID 27289172
We included trials of amitriptyline, citalopram, clomipramine, desipramine, duloxetine, escitalopram, fluoxetine, imipramine, mirtazapine, nefazodone, nortriptyline, paroxetine, sertraline, and venlafaxine. ...In terms of tolerability, fluoxetine was also better than duloxetine (odds ratio [OR] 0·31, 95% CrI 0·13 to 0·95) and imipramine (0·23, 0·04 to 0·78). ...
We included trials of amitriptyline, citalopram, clomipramine, desipramine, duloxetine, escitalopram, fluoxetine, imipramine, mirtaza …
The clinical discovery of imipramine.
Brown WA and Rosdolsky M. Am J Psychiatry 2015. PMID 25930134
Effect of single-dose imipramine on chronic low-back and experimental pain. A randomized controlled trial.
Schliessbach J, et al. PLoS One 2018 - Clinical Trial. PMID 29742109 Free PMC article.
A single oral dose of imipramine 75 mg was compared to active placebo (tolterodine 1 mg) in 50 patients (32 females) with chronic non-specific low-back pain. ...However, evidence for an interaction of the imipramine effect and CYP2D6 genotype was found for electrical and for pressure pain detection thresholds. ...
A single oral dose of imipramine 75 mg was compared to active placebo (tolterodine 1 mg) in 50 patients (32 females) with chronic non …
Imipramine for refractory daytime incontinence in the pediatric population.
Franco I, et al. J Pediatr Urol 2018. PMID 29100969
We evaluated the impact of imipramine on treatment outcomes in children with refractory incontinence. STUDY DESIGN: Children ≤18 years of age with refractory non-neurogenic daytime incontinence prescribed imipramine were identified. ...We observed that over half of children with refractory daytime incontinence reported complete resolution of daytime accidents with imipramine. ...
We evaluated the impact of imipramine on treatment outcomes in children with refractory incontinence. STUDY DESIGN: Children ≤18 year …
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