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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1974 1
1986 1
1987 2
1989 28
1990 68
1991 84
1992 46
1993 36
1994 41
1995 33
1996 39
1997 50
1998 64
1999 71
2000 65
2001 85
2002 115
2003 112
2004 187
2005 210
2006 261
2007 323
2008 299
2009 365
2010 387
2011 455
2012 443
2013 539
2014 476
2015 475
2016 413
2017 366
2018 451
2019 201
2020 1
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6,090 results
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Page 1
Innate Immunity and Neurodegeneration.
Labzin LI, et al. Annu Rev Med 2018 - Review. PMID 29106805
In the brain, microglia represent the key innate immune cells, which are involved in brain development, brain maturation, and homeostasis. ...This review highlights recent advances in our understanding of the influence of innate immunity on neurodegenerative disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's disease....
In the brain, microglia represent the key innate immune cells, which are involved in brain development, brain maturation, and homeost …
Innate immunity: an overview.
Beutler B. Mol Immunol 2004 - Review. PMID 14698223
Though sometimes portrayed as "new," the science of innate immunity made its start more than 100 years ago. Recent progress has reflected the application of new methods to old problems. ...The effector arm of innate immunity has also been tackled, largely though the use of biochemical methods....
Though sometimes portrayed as "new," the science of innate immunity made its start more than 100 years ago. Recent progress ha …
Innate immunity in the central nervous system.
Ransohoff RM and Brown MA. J Clin Invest 2012 - Review. PMID 22466658 Free PMC article.
Furthermore, CNS immune reactions often take place in virtual isolation from the innate/adaptive immune interplay that characterizes peripheral immunity. ...Here we review the cellular and molecular basis of innate immunity in the CNS and discuss what is known about how outcomes of these interactions can lead to resolution of infection, neurodegeneration, or neural repair depending on the context....
Furthermore, CNS immune reactions often take place in virtual isolation from the innate/adaptive immune interplay that characterizes …
Innate immunity.
Masters SL and De Nardo D. Curr Opin Immunol 2014. PMID 24495628
Roles for Innate Immunity in Combination Immunotherapies.
Moynihan KD and Irvine DJ. Cancer Res 2017 - Review. PMID 28928130 Free PMC article.
Immunity to infectious agents involves a coordinated response of innate and adaptive immune cells working in concert, with many feed-forward and regulatory interactions between both arms of the immune system. In contrast, many therapeutic strategies to augment immunity against tumors have focused predominantly on stimulation of adaptive immunity. ...
Immunity to infectious agents involves a coordinated response of innate and adaptive immune cells working in concert, with man
Innate Immunity.
Kaur BP and Secord E. Pediatr Clin North Am 2019 - Review. PMID 31466680
The innate immune response system forms an important line of defense by deploying a limited number of receptors specific for conserved microbial components. ...Improvements in our understanding of the innate immune system have allowed us to explore various therapeutic strategies via modulation of the immune response....
The innate immune response system forms an important line of defense by deploying a limited number of receptors specific for conserve …
Wandering pathways in the regulation of innate immunity and inflammation.
Mantovani A. J Autoimmun 2017 - Review. PMID 29079064 Free PMC article.
Moreover, investigations on TAM have led to the dissection of macrophage plasticity and polarization and to the discovery and analysis of molecular pathways of innate immunity, in particular cytokines, chemokines and PTX3 as a prototypic fluid phase pattern recognition molecule. ...IL-1R2, ACKR2, IL-1R8) in striking a balance between amplification of immunity and resolution versus uncontrolled inflammation and tissue damage; 3) role of humoral innate immunity, illustrated by PTX3, in resistance against selected microbes, regulation of inflammation and immunity and tissue repair, with implications for diagnostic and therapeutic translation....
Moreover, investigations on TAM have led to the dissection of macrophage plasticity and polarization and to the discovery and analysis of mo …
Respiratory epithelial cells orchestrate pulmonary innate immunity.
Whitsett JA and Alenghat T. Nat Immunol 2015 - Review. PMID 25521682 Free PMC article.
Mucociliary clearance in conducting airways, reduction of surface tension in the alveoli, and maintenance of near sterility have been accommodated by the evolution of a multi-tiered innate host-defense system. ...
Mucociliary clearance in conducting airways, reduction of surface tension in the alveoli, and maintenance of near sterility have been accomm …
[Innate immunity].
Takeuchi O. Rinsho Ketsueki 2014 - Review. PMID 25297784 Japanese.
Therapeutic targeting of trained immunity.
Mulder WJM, et al. Nat Rev Drug Discov 2019 - Review. PMID 30967658
This de facto innate immune memory, which has been termed 'trained immunity', provides a powerful 'targeting framework' to regulate the delicate balance of immune homeostasis, priming, training and tolerance. In this Opinion article, we set out our vision of how to target innate immune cells and regulate trained immunity to achieve long-term therapeutic benefits in a range of immune-related diseases. ...
This de facto innate immune memory, which has been termed 'trained immunity', provides a powerful 'targeting framework' to reg …
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