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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 4
1966 10
1967 11
1968 25
1969 67
1970 97
1971 97
1972 77
1973 86
1974 63
1975 64
1976 57
1977 50
1978 50
1979 66
1980 62
1981 48
1982 64
1983 47
1984 80
1985 66
1986 65
1987 63
1988 98
1989 72
1990 96
1991 96
1992 128
1993 116
1994 152
1995 320
1996 539
1997 508
1998 568
1999 537
2000 587
2001 693
2002 683
2003 719
2004 794
2005 814
2006 852
2007 946
2008 1032
2009 1081
2010 1120
2011 1230
2012 1163
2013 1163
2014 1162
2015 1000
2016 994
2017 932
2018 903
2019 432
2020 1
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21,057 results
Results by year
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Page 1
Adverse psychiatric effects of disease-modifying therapies in multiple Sclerosis: A systematic review.
Gasim M, et al. Mult Scler Relat Disord 2018. PMID 30248593 Free article.
Few studies have assessed whether second-generation disease-modifying therapies (DMT) are associated with adverse psychiatric effects. ...Depression was the most commonly reported adverse psychiatric effect. Incidence proportions for all adverse psychiatric effects ranged from 0 to 24.7%. ...
Few studies have assessed whether second-generation disease-modifying therapies (DMT) are associated with adverse psychiatric effe
Neurologic complications in kidney transplant recipients
Piotrowski PC, et al. Folia Neuropathol 2017 - Review. PMID 28677367 Free article.
The intensity, severity and type of abnormalities may vary, and most frequently the complications seem to be associated with a direct or indirect effect of immunosuppressive medications, including their direct effect on cells, on blood vessels, and susceptibility to infections. ...Research on and introduction to clinical practice of new agents like belatacept, proteasome inhibitors, or modified release formulations of tacrolimus, changes the picture and type of abnormalities within the nervous or neuromuscular system but does not eliminate them. ...
The intensity, severity and type of abnormalities may vary, and most frequently the complications seem to be associated with a direct or ind …
[Infections]
Lorenz HM and Kneitz C. Z Rheumatol 2019 - Review. PMID 30659358 German.
The individual risk assessment concerning infections in patients with rheumatic diseases is based on the detailed personalized documentation of relevant risk factors, such as the underlying disease itself, the intensity of immunosuppressive therapy and the severity of any comorbidities. ...
The individual risk assessment concerning infections in patients with rheumatic diseases is based on the detailed personalized documentation …
Interdisciplinary Risk Management in the Treatment of Multiple Sclerosis
Havla J, et al. Dtsch Arztebl Int 2016 - Review. PMID 28130920 Free PMC article.
METHODS: This article is based on pertinent literature retrieved by a selective search in PubMed as well as on documentation of relevant risks and adverse effects in "red hand letters" (information bulletins from pharmaceutical companies to physicians about adverse drug effects) and elsewhere, along with data provided by the German Multiple Sclerosis Competence Network. ...Physicians must, however, give due consideration to potentially severe or even life-threatening adverse drug effects. These can include, for example, transaminase elevation (hepatotoxicity), cardio- and nephrotoxicity, or lympho- and leukopenia with a variable risk of infection. ...
METHODS: This article is based on pertinent literature retrieved by a selective search in PubMed as well as on documentation of relevant ris …
Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel.
Jabs DA, et al. Am J Ophthalmol 2000 - Review. PMID 11024423
CONCLUSIONS: Although corticosteroids represent one of the mainstays in the management of patients with ocular inflammation, in many patients, the severity of the disease, the presence of corticosteroid side effects, or the requirement for doses of systemic corticosteroids highly likely to result in corticosteroid complications supports the rationale for immunosuppressive drugs (for example, antimetabolites, T-cell inhibitors, and alkylating agents) being used in the management of these patients. Because of the potential for side effects, treatment must be individualized and regular monitoring performed. With careful use of immunosuppressive drugs for treatment of ocular inflammatory disorders, many patients will benefit from them either with better control of the ocular inflammation or with a decrease in corticosteroid side effects....
CONCLUSIONS: Although corticosteroids represent one of the mainstays in the management of patients with ocular inflammation, in many patient …
Immunosuppressive agents and interstitial lung disease: what are the risks?
Meyer KC. Expert Rev Respir Med 2014. PMID 24649876
In contrast, some forms of interstitial lung disease can respond well to treatment with immunosuppressive drug therapies. Such agents can, however, be associated with significant risk of adverse effects such as infection, diabetes, osteoporosis, myopathy, bone marrow suppression, hepatitis, urinary tract injury, and drug-induced pneumonitis. ...Some disorders (e.g., cellular non-specific interstitial pneumonia, organizing pneumonia, or sarcoidosis) may respond very well to immunosuppressive therapies including corticosteroids as monotherapy, and the use of steroid-sparing agents can minimize corticosteroid side effects and may enhance treatment efficacy for disorders such as sarcoidosis or connective tissue disease-associated forms of interstitial lung disease....
In contrast, some forms of interstitial lung disease can respond well to treatment with immunosuppressive drug therapies. Such age
How do we manage and treat a patient with multiple sclerosis at risk of tuberculosis?
Fragoso YD, et al. Expert Rev Neurother 2014 - Review. PMID 25242167
In conditions that affect the immune system, such as multiple sclerosis (MS), latent tuberculosis may thrive and reactivate during the use of immunomodulatory and immunosuppressive drugs. ...
In conditions that affect the immune system, such as multiple sclerosis (MS), latent tuberculosis may thrive and reactivate during the use o …
Complications of immunosuppressive agents therapy in transplant patients.
Reske A, et al. Minerva Anestesiol 2015 - Review. PMID 25251864 Free article.
Approximately one third of organ recipients require hospital readmission after transplantation because of a multitude of clinical problems related to immunosuppressive therapy. We review the current knowledge on typical complications associated with immunosuppressants with emphasis on the intensivist's perspective....
Approximately one third of organ recipients require hospital readmission after transplantation because of a multitude of clinical problems r …
Impact of preoperative immunosuppressive agents on postoperative outcomes in Crohn's disease.
Ahmed Ali U, et al. Dis Colon Rectum 2014 - Review. PMID 24819109
BACKGROUND: Immunosuppressive agents are essential in the management of Crohn's disease. Their safety before surgery, however, is still controversial. ...CONCLUSIONS: Patients with Crohn's disease on preoperative immunosuppressive agents are at higher risk for complications. Both corticosteroids and anti-tumor necrosis factor agents may increase the risk of infections and septic shock. ...
BACKGROUND: Immunosuppressive agents are essential in the management of Crohn's disease. Their safety before surgery, however, …
Neurotoxicity of commonly used hepatic drugs
Ahrens CL and Manno EM. Handb Clin Neurol 2014 - Review. PMID 24365346
Neurologic complications are common side-effects of immunosuppressive medications used in the prevention of graft rejection after organ transplantation. ...Depression is the most commonly encountered neurotoxicity; however, severe but rare adverse neurological effects related to these therapies have been reported. ...
Neurologic complications are common side-effects of immunosuppressive medications used in the prevention of graft rejection af …
21,057 results
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